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421“…This achievement is a milestone for the development of new high sensitivity devices and opens the door to new industrial applications, such as gear oil degradation, or biomedical devices where previous devices could not provide enough sensitivity.…”
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422“…Gene and cell therapy research recently reached a fundamental milestone toward the goal to deliver new medicines for orphan diseases. …”
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423por Shen, Jie, Swift, Brandon, Mamelok, Richard, Pine, Samuel, Sinclair, John, Attar, Mayssa“…A milestone step in translational science to transform basic scientific discoveries into therapeutic applications is the advancement of a drug candidate from preclinical studies to initial human testing. …”
Publicado 2018
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424por Hale, Jaime E., Darras, Basil T., Swoboda, Kathryn J., Estrella, Elicia, Chen, Jin Yun Helen, Abbott, Mary-Alice, Hay, Beverly N., Kumar, Binod, Counihan, Anne M., Gerstel-Thompson, Jacalyn, Sahai, Inderneel, Eaton, Roger B., Comeau, Anne Marie“…Massachusetts began newborn screening (NBS) for Spinal Muscular Atrophy (SMA) following the availability of new treatment options. The New England Newborn Screening Program developed, validated, and implemented a screening algorithm for the detection of SMA-affected infants who show absent SMN1 Exon 7 by Real-Time™ quantitative PCR (qPCR). …”
Publicado 2021
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425por Blondel, A, Bueno, A G, Campanelli, M, Cervera-Villanueva, Anselmo, Cline, David B, Collot, J, De Jong, M, Donini, Andrea, Dydak, Friedrich, Edgecock, R, Gavela-Legazpi, Maria Belen, Gómez-Cadenas, J J, González-Garciá, M Concepción, Gruber, P M, Harris, D A, Hernández, Pilar, Kuno, Y, Litchfield, P J, McFarland, K, Mena, O, Migliozzi, P, Palladino, Vittorio, Panman, J, Papadopoulos, I M, Para, A, Peña-Garay, C, Pérez, P, Rigolin, Stefano, Romanino, Andrea, Rubbia, André, Strolin, P, Wojcicki, S G“…The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a new window to the still mysterious origin of masses and flavour-mixing. …”
Publicado 2000
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426por Matteelli, Alberto, Rendon, Adrian, Tiberi, Simon, Al-Abri, Seif, Voniatis, Constantia, Carvalho, Anna Cristina C., Centis, Rosella, D'Ambrosio, Lia, Visca, Dina, Spanevello, Antonio, Battista Migliori, Giovanni“…Furthermore, the eight core activities recently proposed by WHO as the milestones to achieve TB elimination are discussed in detail. …”
Publicado 2018
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427por Maccolini, Serena“…We present recent results obtained during the current year, including the first observation of a non-zero mass difference between the neutral charm eigenstates – a new milestone in charm physics.…”
Publicado 2021
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428por Heuchel, Daniel“…For this large sample of photosensors a new approach of quality control was required to sufficiently characterise and monitor device parameters for both, test bench and in-situ beam test data. …”
Publicado 2022
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429por Hashan, Hajed M., Al-Muteb, Sarah K., Alismail, Ibrahim A., Alsaleh, Othman N., Alkherb, Zakiya M., McAuslane, Neil, Walker, Stuart R.“…METHODS: A standardised data collection template enabled the structured documentation of information collected by the Senior Regulatory Affairs and Regulatory Affairs Specialists from the Executive Board of the Health Ministers Council for GCC States to determine the GHC structure, resources, review models and milestones and timelines. The total number of applications approved was provided together with the average yearly timelines for new active substances and generics from January 2015 to December 2020 including both scientific assessment time from the agency as well as applicant response time to questions raised. …”
Publicado 2022
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430por Brito, Allan“…The release of Blender 2.8 is a milestone for any artist using Blender to create digital art. …”
Publicado 2019
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431“…The reduction in costs and in the time needed for experiments to predict the pharmacological activities of new molecules is a milestone in science. These successful applications of AI algorithms provide hope for a revolution in healthcare systems. …”
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432“…About eight years ago, a new automation approach and flow technique called “Lab-In-Syringe” was proposed. …”
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433por Fanciulli, Giuseppe, Di Molfetta, Sergio, Dotto, Andrea, Florio, Tullio, Feola, Tiziana, Rubino, Manila, de Cicco, Federica, Colao, Annamaria, Faggiano, Antongiulio“…Besides, the newly detected predictors of response will (hopefully) be of great helps in selecting the subset of patients that might benefit the most from this class of drugs. Finally, new trials are in the starting blocks, and they are expected to shed in the next future new light on a therapy, which is considered a milestone in oncology.…”
Publicado 2020
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434por Listro, Roberta, Rossino, Giacomo, Piaggi, Federica, Sonekan, Falilat Folasade, Rossi, Daniela, Linciano, Pasquale, Collina, Simona“…Suramin was the first urea-based drug to be approved in clinic, and in the following century a number of milestone drugs based on this scaffold were developed. …”
Publicado 2022
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435por Hoermann, Henrike, Roeper, Marcia, Dafsari, Roschan Salimi, Koestner, Felix, Schneble, Dominik, von Zezschwitz, Dunja, Mayatepek, Ertan, Kummer, Sebastian, Meissner, Thomas“…Acceptance and feasibility of the new standard are assessed using questionnaires. …”
Publicado 2022
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436
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437“…More than a decade ago genetically encoded calcium indicators (GECIs) entered the stage as new promising tools to image calcium dynamics and neuronal activity in living tissues and designated cell types in vivo. …”
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438por Spitaleri, Gianluca, Trillo Aliaga, Pamela, Attili, Ilaria, Del Signore, Ester, Corvaja, Carla, Corti, Chiara, Uliano, Jacopo, Passaro, Antonio, de Marinis, Filippo“…Moreover, the treatment landscape of this disease has radically changed in recent years thanks to the introduction of new selective and potent MET inhibitors (MET-Is). …”
Publicado 2023
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439“…In 2010 EMA introduced a new policy on access to regulatory documents, including CSRs, and has also undertaken further steps. …”
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440por Testori, A, Soteldo, J, Powell, B, Sales, F, Borgognoni, L, Rutkowski, P, Lejeune, F, van Leeuwen, PAM, Eggermont, A“…The surgical subgroup of the EORTC Melanoma Group is developing a new version of the surgical survey questionnaire including new treatment modalities like isolated limb infusion and electrochemotherapy, which were not frequently in use some years ago, to obtain new data to be compared to the nearly ten-year-old data.…”
Publicado 2013
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