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441“…In recent years, immunocheckpoint blocking therapy targeting the PD‐1/PD‐L1 axis has achieved good results in a variety of malignant tumors, pushing tumor immunotherapy to a new milestone, such as anti‐PD‐1 monoclonal antibody Nivolumab, Pembrolizumab, and anti‐PD‐L1 monoclonal antibody Atezolizumab, which are considered as potential antitumor drugs. …”
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442por Huang, Xiaoqing, Li, Zihua, Wang, Jiali, Cao, Endong, Zhuang, Guiying, Xiao, Fei, Zheng, Caihua, Zhang, Xiaowen, Chen, Man, Gao, Liqing, Guo, Pi, Lin, Peiwei, Zheng, Shaoyan, Xin, Gang“…The system consists of 36 competency indicators, a rating scale of 5 proficiency levels, and a gap analysis to measure competency evolution through 3 key milestones in clinician’s professional career: new graduate, resident physician, and senior physician. …”
Publicado 2022
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443por Rice, Selena L., Lazarus, Elena, Anderton, Christopher, Birnbaum, Kenneth, Brophy, Jennifer, Cole, Benjamin, Dickel, Diane, Ehrhardt, David, Fahlgren, Noah, Frank, Margaret, Haswell, Elizabeth, Huang, Shao‐shan Carol, Leiboff, Samuel, Libault, Marc, Otegui, Marisa S., Provart, Nicholas, Uhrig, R. Glen, Rhee, Seung Y.“…In conclusion, the development of a data synthesis center will help the PCA community achieve these goals by providing a centralized repository for existing and new data, a platform for sharing tools, and new analytical approaches through collaborative, multidisciplinary efforts. …”
Publicado 2022
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444por van Oorsouw, Roel, Klooster, Emily, Koenders, Niek, Van Der Wees, Philip J., Van Den Boogaard, Mark, Oerlemans, Anke J. M.“…RESULTS: The analysis yielded five themes: ‘waking up in alienation’, ‘valuing human contact in isolation’, ‘making progress by being challenged’, ‘coming home but still recovering’ and ‘finding a new balance’. The phenomenological descriptions reflect a recovery process that does not follow a linear build‐up, but comes with moments of success, setbacks, trying new steps and breakthrough moments of achieving mobilizing milestones. …”
Publicado 2022
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445por Ferrer-Mallol, Elisa, Matthews, Clare, Stoodley, Madeline, Gaeta, Alessandra, George, Elinor, Reuben, Emily, Johnson, Alex, Davies, Elin Haf“…Longitudinal studies to validate DMD home as a new methodology to predict progression to the non-ambulant stage will be pursued.…”
Publicado 2022
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446por Blondel, A, Bueno, A G, Campanelli, M, Cervera-Villanueva, Anselmo, Cline, David B, Collot, J, De Jong, M, Donini, Andrea, Dydak, Friedrich, Edgecock, R, Gavela-Legazpi, Maria Belen, Gómez-Cadenas, J J, González-Garciá, M Concepción, Gruber, P, Harris, D A, Hernández, Pilar, Kuno, Y, Litchfield, P J, McFarland, K, Mena, O, Migliozzi, P, Palladino, Vittorio, Panman, J, Papadopoulos, I M, Para, A, Peña-Garay, C, Pérez, P, Rigolin, Stefano, Romanino, Andrea, Rubbia, André, Strolin, P, Wojcicki, S G“…The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a new window to the still mysterious origin of masses and flavour mixing. …”
Publicado 2000
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447por Lorini, Chiara, Del Riccio, Marco, Zanobini, Patrizio, Biasio, Roberto Luigi, Bonanni, Paolo, Giorgetti, Duccio, Ferro, Valerio Allodola, Guazzini, Andrea, Maghrebi, Olfa, Lastrucci, Vieri, Rigon, Lisa, Okan, Orkan, Sørensen, Kristine, Bonaccorsi, Guglielmo“…Based on the findings of the scoping review, a new and comprehensive definition was proposed by a panel of experts. …”
Publicado 2023
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448“…The precision measurement of the W boson mass is an important milestone for the LHC physics program in the coming years. …”
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449“…A perspective of future research is that sequence and responsiveness profiling of RLPs can provide a new platform for the design and development of new modular RLP-based biomaterials with programmable structure, properties and functions.…”
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450“…Since the only and the milestone FDA approval of becaplermin gel (Regranex(TM), 0.01% human recombinant PDGF-BB) as a (diabetic) wound healing therapeutic more than 25 years ago, no new therapeutic (excluding physical therapies, devices, dressings, anti-microbial agents, or other preventive treatments) for any type of wound healing has advanced to clinical applications. …”
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451por Saeed, Muhammad, Hussain, Shahida, Riaz, Saba, Rasheed, Farhan, Ahmad, Maqsood, Iram, Shagufta, Arif, Mizna, Rahmani, Tariq Hamid, Anwar, Ambereen Imran“…While in HIV-negative and TB suspected cases, the sensitivity and specificity were 95.6% and 100%. This new test represents a major milestone for global TB diagnosis and care. …”
Publicado 2020
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452por Kondinski, Aleksandar, Rasmussen, Maren, Mangelsen, Sebastian, Pienack, Nicole, Simjanoski, Viktor, Näther, Christian, Stares, Daniel L., Schalley, Christoph A., Bensch, Wolfgang“…This new model represents a milestone on the way to rational and designable POV self-assemblies.…”
Publicado 2022
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453por Khera, Gunjan, Chandrika Yelisetty, Ratna, Spence, Gavin Malcolm, AlAhbabi, Waala Dhafer Masoud Hadi, Dadzie, Vanessa Baaba“…This study serves as a new guide for parents, as they raise young children in the new normal. …”
Publicado 2023
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454“…Furthermore, recent technological advances present new opportunities which can be leveraged in this context. …”
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455por Kutmon, Martina, Riutta, Anders, Nunes, Nuno, Hanspers, Kristina, Willighagen, Egon L., Bohler, Anwesha, Mélius, Jonathan, Waagmeester, Andra, Sinha, Sravanthi R., Miller, Ryan, Coort, Susan L., Cirillo, Elisa, Smeets, Bart, Evelo, Chris T., Pico, Alexander R.“…We introduce the Quick Edit feature for pathway authors and curators, in addition to new means of publishing pathways and maintaining custom pathway collections to serve specific research topics and communities. …”
Publicado 2016
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456por Afolabi, Lukman O, Afolabi, Mariam O, Sani, Musbahu M, Okunowo, Wahab O, Yan, Dehong, Chen, Liang, Zhang, Yaou, Wan, Xiaochun“…Intensive research on the CRISPR‐Cas9 system has provided scientists with the ability to overcome the hostile tumor microenvironment and generate more products for future clinical use, especially off‐the‐shelf, universal cellular products, bringing exciting milestones for immunotherapy. This review discussed the application and challenges of CRISPR technology in cancer research and immunotherapy, its advances and prospects for promoting new cell‐based therapeutic beyond immune oncology.…”
Publicado 2021
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457por Sandstroem, A R“…The observation of electroweak boson ($W,Z$) and top quark pair ($tar{t}$) production is one of the key milestones for the early LHC physics programme. Production of $tar{t}$, $W$ and $Z$ in association with jets are important backgrounds in various searches for physics beyond the Standard Model, and new physics may also give rise to additional production mechanisms or modification of the decay channels. …”
Publicado 2011
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458por Jensen, L“…The test of the new transfer line between SPS point 4 and LHC point 8 was an important milestone for the AB/BDI group. …”
Publicado 2004
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459por Azzurri, Paolo“…The major result is the first evidence for the Higgs boson decay to a pair of muons, and therefore for its coupling to second generation fermions, a milestone in establishing the Higgs boson properties. …”
Publicado 2020
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460por Papadelis, Aras“…The observation of top quark pair (tt) production is one of the key milestones for the early LHC physics programme. The abundant tt sample which is expected to be produced in the first years of data-taking can be exploited for improving many aspects of detector performance. …”
Publicado 2010
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