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521“…The recent discovery of immune checkpoint inhibitors is a significant milestone in cancer immunotherapy research. However, some patients with primary or adaptive drug resistance might not benefit from the overall therapeutic potential of immunotherapy in oncology. …”
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522“…In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). …”
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523por Maras, Steven“…In 2019, the Australian and New Zealand Communication Association (ANZCA) celebrated its 25th anniversary. …”
Publicado 2020
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524por Gadek, Tomasz, Blanchot, Georges, Gajanec, Rafael, Honma, Alan, Kovacs, Mark Istvan“…In this work, the development milestones and the final designs are presented together with chosen solutions.…”
Publicado 2018
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525por Chen, Chufeng, Liu, Jiaying, Chen, Yidong, Lin, Anqi, Mou, Weiming, Zhu, Lingxuan, Yang, Tao, Cheng, Quan, Zhang, Jian, Luo, Peng“…The discovery of the immune checkpoint pathway is an important milestone in understanding and reversing T cell exhaustion. …”
Publicado 2022
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526“…After reading this chapter and answering the discussion questions that follow, you should be able to: Outline important milestones in the emergence of vaccines as a means of disease control and prevention. …”
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527“…This panorama seeks to constitute a referent for strategic reflection, which inspires new generations to meet the research challenges and teach care research.…”
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528
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529“…Studies during the last two decades have provided new insights into the molecular mechanism of Alzheimer's disease (AD). …”
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530por Gee, Tikki“…Singapore’s Ministry of Health’s (MOH) response to these impending challenges has been swift and reforms are under way that will lead to new models of care, integrated care delivery capabilities as well as increased capacity (through development of primary care and new facilities) in light of growing demands. …”
Publicado 2012
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531por Konig, Axel“…Milestones in sensor R&D for the 2S modules as well as first characterization results are presented. …”
Publicado 2016
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532“…The future programme of the Advanced Wakefield (AWAKE) experiment at CERN relies on the seeded self-modulation of an entire proton bunch, resulting in phase-reproducible micro-bunches. This important milestone was achieved during the 2021 proton run by injecting a short electron bunch ahead of the proton bunch, demonstrating for the first time the electron-seeding of proton bunch self-modulation. …”
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533por Lopez Solis, Alvaro“…Theories beyond the Standard Model accommodate dark matter by considering a new dark sector interacting with the Standard Model particles via heavy mediators. …”
Publicado 2022
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534por Traczyk, Piotr Wojciech“…Group photo at SM18 to commemorate a significant milestone : the installation of Power Converters on the HL-LHC IT String metallic platform. …”
Publicado 2023
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535por Kraus, W. Lee“…Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. …”
Publicado 2020
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536por Subash, Meera, Sakumoto, Matthew, Bass, Jeremy, Hong, Peter, Muniyappa, Anoop, Pierce, Logan, Purmal, Colin, Ramaswamy, Priya, Sono, Reiri, Uptegraft, Colby, Feinstein, David, Khanna, Raman“…Telehealth projects included training providers on existing telehealth tools, building entirely new virtual clinics for video triage of COVID-19 patients, and pioneering workflows and implementation of brand-new emergency department and inpatient video visit types. …”
Publicado 2020
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537por Perez-Riverol, Yasset, Xu, Qing-Wei, Wang, Rui, Uszkoreit, Julian, Griss, Johannes, Sanchez, Aniel, Reisinger, Florian, Csordas, Attila, Ternent, Tobias, del-Toro, Noemi, Dianes, Jose A., Eisenacher, Martin, Hermjakob, Henning, Vizcaíno, Juan Antonio“…We believe that the PRIDE Inspector Toolsuite represents a milestone in the visualization and quality assessment of proteomics data. …”
Publicado 2016
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538por Barylski, Jakub, Enault, François, Dutilh, Bas E, Schuller, Margo BP, Edwards, Robert A, Gillis, Annika, Klumpp, Jochen, Knezevic, Petar, Krupovic, Mart, Kuhn, Jens H, Lavigne, Rob, Oksanen, Hanna M, Sullivan, Matthew B, Jang, Ho Bin, Simmonds, Peter, Aiewsakun, Pakorn, Wittmann, Johannes, Tolstoy, Igor, Brister, J Rodney, Kropinski, Andrew M, Adriaenssens, Evelien M“…We are convinced that creation of this novel family is a crucial milestone toward much-needed reclassification in the Caudovirales order.…”
Publicado 2019
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539“…Lastly, the new criteria provide specifiers to better describe clinical presentations for use in neuropsychological assessment. …”
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540por Fogerson, Stephanie M., Mortensen, Richard D., Moore, Regan P., Chiou, Hellen Y., Prabhu, Neel K., Wei, Angela H., Tsai, Daniel, Jadi, Othmane, Andoh-Baidoo, Kwabena, Crawford, Janice, Mudziviri, Murotiwamambo, Kiehart, Daniel P.“…Cell sheet morphogenesis is essential for metazoan development and homeostasis of animal form – it contributes to developmental milestones including gastrulation, neural tube closure, heart and palate formation and to tissue maintenance during wound healing. …”
Publicado 2020
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