“…The discovery of the Brout-Englert-Higgs boson at the Large Hadron Collider in 2012 marked the final milestone in completing this model as we know it today. …”
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“…Here we show that the mouse phenotypes are replicated with new genetic alleles, but are modulated by genetic background and environmental effects, as demonstrated by several new mouse strains and backcrossing of the original Naa10 null allele 20 generations to inbred C57BL/6J mice in a different animal facility. …”
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“…Despite the rapid development and multitude of new treatment approaches for ACL injuries in the last 20 years, autografting has remained the treatment of choice. …”
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“…The well-known cardiovascular risk factors require new and more efficient public health approaches to the prevention and control. …”
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“…Moreover, their precise involvement in the origin and progression of the disease was one of the milestone discoveries regarding these molecules. New multi-omic techniques have enabled researchers to advance in the knowledge of medulloblastoma, adding complexity to the matter. …”
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“…BACKGROUND: The completion of the Plasmodium falciparum genome represents a milestone in malaria research. The genome sequence allows for the development of genome-wide approaches such as microarray and proteomics that will greatly facilitate our understanding of the parasite biology and accelerate new drug and vaccine development. …”
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“…Barriers in moving along the road towards making a new drug available include insufficient manufacturing capacity; knowledge sharing between scientists and medical healers; regulatory hurdles; quality control issues; pricing and distribution; and lack of financing. …”
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“…I hereby review the most important milestones in diagnosis techniques of avian haemosporidian parasites and illustrate how they provide new insights for understanding host–parasite associations.…”
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“…RESULTS/ANTICIPATED RESULTS: The PHP has progressed in its envisioned shared university-public health stewardship of translation and transformation. Milestones included galvanizing activities such as annual regional dissemination, implementation, and improvement (DII) symposia and Public Health Science Summits; pre- and post-doctoral experiential learning of system science and learning system methods based in Los Angeles County Health Agency initiatives; development of a regional CTSA network for implementation science training; strengthened public health policy practice (e.g., establishing a new Office of Youth Diversion and Development); learning healthcare system capability; and prototypes of population learning systems focused on hypertension, food insecurity, tobacco/vaping, and complex care management. …”
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“…In this review, we intended to understand the milestones that have had an impact on this disease up to their implementation in clinical practice. …”
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“…Five of the 20 children (25.0%) reached new developmental milestones or acquired new skills after VNS compared to the preoperative evaluation. …”
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“…OBJECTIVE: To evaluate whether indexes of glycemic variability may overcome residual β-cell secretion estimates in the longitudinal evaluation of partial remission in a cohort of pediatric patients with new-onset type 1 diabetes. RESEARCH DESIGN AND METHODS: Values of residual β-cell secretion estimates, clinical parameters (e.g., HbA(1c) or insulin daily dose), and continuous glucose monitoring (CGM) from 78 pediatric patients with new-onset type 1 diabetes were longitudinally collected during 1 year and cross-sectionally compared. …”
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“…This paper focuses on the importance management lessons from these milestones and the potential new therapeutic strategies which may be looming in the near future.…”
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“…Second, recovery is a process of personal growth with developmental milestones. Each stage of recovery has its own risks of relapse. …”
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“…The new development and finally the general acceptance of surgical techniques among the worldwide surgical community sometimes create fascinating stories. …”
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“…The availability of a vast array of recombinant and synthetic IMMUNOMODULATORS is a significant milestone toward the development of effective therapies for infectious diseases. …”
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“…Although the bottom-up construction of a protocell that can be considered truly ‘alive’ is still an ambitious goal, these man-made constructs with a certain degree of ‘liveness’ can offer effective tools to understand fundamental processes of cellular life, and have paved the new way for bionic applications. In this review, we highlight both the milestones and recent progress of protocells programmed by artificial reaction networks, including genetic circuits, enzyme-assisted non-genetic circuits, prebiotic mimicking reaction networks, and DNA dynamic circuits. …”
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“…While the infant did have some adverse effects related to prematurity, she met developmental milestones and was alive and well at the age of two. …”
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“…Here, we provide a brief history of the milestones that have advanced liver surgery, and review some of the new insights offered by the interdisciplinary work using animals, in vitro models, tissue engineering, or mathematical models to help advance the knowledge on liver regeneration. …”
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“…Most children admitted to PICU are under five years of age, and the stressors of critical illness and necessary interventions can affect their ability to meet crucial developmental milestones. Understanding the neuroscience of brain development and vulnerability can inform PICU clinicians of new ways to enhance and support the care of these most vulnerable children and families. …”
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