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661“…In order to make gains in the field of immunotherapy, one had to be willing to confront ideas and concepts that seemed to contradict one another, and reconcile how each could be true. This is what led to new knowledge and advances. Here, we highlight some of these paradoxes and the milestone discoveries that followed, each one critical for our understanding of immune checkpoint pathways. …”
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662“…In new drug development process, one of the most important milestones for a drug candidate is to establish Proof of Concept (PoC) at early Phase II stage. …”
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663por Cianci, Stefano, Arcieri, Martina, Vizzielli, Giuseppe, Martinelli, Canio, Granese, Roberta, La Verde, Marco, Fagotti, Anna, Fanfani, Francesco, Scambia, Giovanni, Ercoli, Alfredo“…The growing application of the minimally invasive surgical approach unlocked new perspectives for gynecologic oncology surgery. …”
Publicado 2021
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664“…Buprenorphine-based medications were first approved by the United States Food and Drug Administration in 2002 for the treatment of opioid dependence, or opioid use disorder (OUD) as the condition is presently known. This regulatory milestone was the outcome of 36 years of research and development, which also led to the development and approval of several other new buprenorphine-based medications. …”
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665por Schady, Patricia“…In this review, I summarize some of the milestones made in GRB research during the Swift era, and how previous widely accepted theoretical models have had to adapt to accommodate the new wealth of observational data.…”
Publicado 2017
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666por van der Laan, Kiran J., Morita, Aryan, Perona-Martinez, Felipe P., Schirhagl, Romana“…Only minimal, transient FND-related stress effects were observed, highlighting excellent biocompatibility in the long term. This is a crucial milestone towards the applicability of FNDs as biosensors in free radical research.…”
Publicado 2020
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667“…Finally, the compactness of our new encoding makes it feasible to translate realistic game problems. …”
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668“…The aim of this review is to showcase the importance of this scientific milestone for the development of additional mRNA therapeutics. …”
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669“…The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency.…”
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670“…Here, we comprehensively review the historical milestones and latest updates in PROTAC technology. …”
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671“…This initiative is being undertaken to meet the new standards of medical education in Canada, which include social accountability to meet performance-based outcomes of training. …”
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672por Langley, Ricky L, Kao, Yimin, Mort, Sandra A., Bateman, Allen, Simpson, Barbara D., Reich, Brian J“…Since 1998, North Carolina has tested all new private wells for manganese, arsenic and lead. …”
Publicado 2015
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673por Branford, Susan“…The success of discontinuation trials has led to new treatment strategies in order for more patients to reach this milestone response. …”
Publicado 2020
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674“…We introduce vertebrate segmentation and Notch signalling, pointing out historical milestones, then describe existing models for the Notch pathway in the synchronization of noisy neighbouring oscillators, and a new role in the modulation of gene expression wave patterns. …”
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675Proceedings of the ILC Physics Working Group Meeting at KEK in the period from May 2007 to June 2009por Ikematsu, Katsumasa, Okada, Yasuhiro, Ono, Hiroaki, Kanemura, Shinya, Suehara, Taikan, Takubo, Yosuke, Tanabe, Tomohiko, Fujii, Keisuke“…This report ummarizes the progress made in this period and sets a milestone for future developments in ILC physics.…”
Publicado 2010
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676“…A source of exciting cross-fertilization and new ideas for extensive future research, this volume will be of great interest to any researcher or graduate student interested in the interaction of control and information theory.…”
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677“…Based on new information obtained on free microjets, this book explains the latest phenomena in flame evolution in the presence of a transverse acoustic field with round and plane propane microjet combustion. …”
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678por Arbouch, Emmanuel Jean“…This study is the first milestone towards assessing ultimately the gain brought by the HGTD to the VBF analyses. …”
Publicado 2016
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679“…This is the first book to introduce the irrational elliptic function series, providing a theoretical treatment for the smooth and discontinuous system and opening a new branch of applied mathematics. The discovery of the smooth and discontinuous (SD) oscillator and the SD attractors discussed in this book represents a further milestone in nonlinear dynamics, following on the discovery of the Ueda attractor in 1961 and Lorenz attractor in 1963. …”
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680por Ariga, Tomoko“…A 2.7$\sigma$ excess of neutrino-like signal above the background was measured. This milestone opens a new avenue for studying neutrinos at the existing and future high-energy colliders. …”
Publicado 2022
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