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781por Strobl, M. A. R., Gallaher, J., Robertson-Tessi, M., West, J., Anderson, A. R. A.“…Cancer research has traditionally focused on developing new agents, but an underexplored question is that of the dose and frequency of existing drugs. …”
Publicado 2023
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782“…Basic research in sarcoma models has been fundamental in the discovery of scientific milestones leading to a better understanding of the molecular biology of cancer. …”
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783por Robert, Cyrille, Pasquier, Laurent, Cohen, David, Fradin, Mélanie, Canitano, Roberto, Damaj, Léna, Odent, Sylvie, Tordjman, Sylvie“…Progress in epidemiological, molecular and clinical genetics with the development of new techniques has improved knowledge on genetic syndromes associated with autism spectrum disorder (ASD). …”
Publicado 2017
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784“…Determining the pathophysiological processes of frozen shoulder is a pivotal milestone in the development of novel treatment for patients with frozen shoulder. …”
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785“…This review also describes future directions, perspectives and challenges in developing this alternative technology, which will help us reach a new milestone in designing an effective arsenic detector for commercial use.…”
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786por Badawy, Charles R., Jan, Kyleen, Beck, Edward C., Fleet, Niles, Taylor, Jeffrey, Ford, Kevin, Waterman, Brian R.“…Based on clinical experience, a renewed focus on objective, criteria-based milestones may maximize the ability of return to preinjury levels of athletic function.…”
Publicado 2022
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787“…INTRODUCTION: Long-acting injectable antipsychotics (LAIs) have emerged as a new therapeutic option to treat patients suffering a psychotic disorder. …”
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788por Zoia, C., Mantovani, G., Müther, M., Suero Molina, E., Scerrati, A., De Bonis, P., Cornelius, J.F., Roche, P.H., Tatagiba, M., Jouanneau, E., Manet, R., Schroeder, H.W.S., Cavallo, L.M., Kasper, E.M., Meling, T.R., Mazzatenta, D., Daniel, R.T., Messerer, M., Visocchi, M., Froelich, S., Bruneau, M., Spena, G.“…Since its first application in 2009, transorbital endoscopic surgery opened the way for new surgical scenario, previously feasible only with extensive tissue dissection. …”
Publicado 2023
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789por Godin, Antoine G., Setaro, Antonio, Gandil, Morgane, Haag, Rainer, Adeli, Mohsen, Reich, Stephanie, Cognet, Laurent“…The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. …”
Publicado 2019
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790por Park, Kee Hyung, Jang, Jae-Won, Suh, Jeewon, Yi, SangHak, Bae, Jae-Sung, Lim, Jae-Sung, Lee, Hyon, Chin, Juhee, Park, Young Ho, Hong, Yun Jeong, Kim, Geon Ha“…This will be an important milestone to widen the latest knowledge in the research of AD’s diagnosis, therapeutics, pathogenesis that can lead to the establishment of future directions.…”
Publicado 2022
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791por Kagan, H, Alexopoulos, A, Artuso, M, Bachmair, F, Bäni, L, Bartosik, M, Beacham, J, Beck, H, Bellini, V, Belyaev, V, Bentele, B, Bergonzo, P, Bes, A, Brom, J -M, Bruzzi, M, Chiodini, G, Chren, D, Cindro, V, Claus, G, Collot, J, Cumalat, J, Dabrowski, A, D'Alessandro, R, Dauvergne, D, de Boer, W, Dick, S, Dorfer, C, Dunser, M, Eremin, V, Forcolin, G, Forneris, J, Gallin-Martel, L, Gallin-Martel, M -L, Gan, K K, Gastal, M, Giroletti, C, Goffe, M, Goldstein, J, Golubev, A, Gorišek, A, Grigoriev, E, Grosse-Knetter, J, Grummer, A, Gui, B, Guthoff, M, Haughton, I, Hiti, B, Hits, D, Hoeferkamp, M, Hofmann, T, Hosslet, J, Hostachy, J -Y, Hügging, F, Hutton, C, Janssen, J, Kanxheri, K, Kasieczka, G, Kass, R, Kassel, F, Kis, M, Kramberger, G, Kuleshov, S, Lacoste, A, Lagomarsino, S, Lo Giudice, A, Lukosi, E, Maazouzi, C, Mandic, I, Mathieu, C, Menichelli, M, Mikuž, M, Morozzi, A, Moss, J, Mountain, R, Murphy, S, Muškinja, M, Oh, A, Olivero, P, Passeri, D, Pernegger, H, Perrino, R, Picollo, F, Pomorski, M, Potenza, R, Quadt, A, Re, A, Reichmann, M, Riley, G, Roe, S, Sanz, D, Scaringella, M, Schaefer, D, Schmidt, C J, Smith, D S, Schnetzer, S, Sciortino, S, Scorzoni, A, Seidel, S, Servoli, L, Sopko, B, Sopko, V, Spagnolo, S, Spanier, S, Stenson, K, Stone, R, Sutera, C, Taylor, A, Tannenwald, B, Traeger, M, Tromson, D, Trischuk, W, Tuve, C, Velthuis, J, Venturi, N, Vittone, E, Wagner, S, Wallny, R, Wang, J C, Weingarten, J, Weiss, C, Wengler, T, Wermes, N, Yamouni, M, Zavrtanik, M“…The startup of the LHC in 2015 brought a new milestone where the first polycrystalline CVD (pCVD) diamond pixel modules were installed in an LHC experiment and successfully began operation. …”
Publicado 2019
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792por Peggiani, Sonia“…The development of cutting-edge 11-12 T superconducting magnets made from Nb$_{3}$Sn technology is one of the major milestones for the upgrade of the Large Hadron Collider at CERN. …”
Publicado 2017
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793“…Understanding structure–activity relationships can facilitate the development of new MOFs. Transmission electron microscopy (TEM) is a powerful technique to characterize the microstructures of MOFs at the atomic scale. …”
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794“…The discovery of semiconductive polyacetylene by Heeger et al. in the late 1970s was a milestone towards the use of organic materials in electronics; the development of efficient protocols for the palladium catalyzed alkynylation reactions and the new conception of steric and conformational advantages of acetylenes have been recently focused the attention on conjugated triple-bond containing systems as a promising class of semiconductors for OPVs applications. …”
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795“…Such “unitary-protocells”, containing a central genetic molecule, may have appeared as a milestone—in principle, since then life could evolve endlessly, “gaining” more and more functions by introducing new genes. …”
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796por Ułamek-Kozioł, Marzena, Czuczwar, Stanisław J., Januszewski, Sławomir, Pluta, Ryszard“…Since 1990, the number of publications on attempts to treat drug-resistant epilepsy with a ketogenic diet has grown so rapidly that it has become a challenge to see the overall trajectory and major milestones achieved in this field. In this review, we hope to provide the latest data from randomized clinical trials, practice guidelines, and new research areas over the past 2 years.…”
Publicado 2019
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797“…Here, we summarize recent discoveries and milestones on the TGF-β signaling pathway related to liver fibrosis and hepatic stellate cell (HSC) activation, emphasizing research of the last five years. …”
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798“…To a summary of our work, an update on the subject is provided with the intention of sharing experiences and facilitating the start-up of the new units.…”
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799por Ndagi, Umar, Falaki, Abubakar A., Abdullahi, Maryam, Lawal, Monsurat M., Soliman, Mahmoud E.“…With the discovery of penicillin by Alexander Fleming in 1924, a milestone in bacterial infections' treatment was achieved. …”
Publicado 2020
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800por Skinner, Mark W., Nugent, Diane, Wilton, Pam, O’Mahony, Brian, Dolan, Gerry, O’Hara, Jamie, Berntorp, Erik“…A treatment model was developed by a panel of haemophilia providers, patient advocates and health economists to establish specific treatment milestones and targeted outcomes. The panel defined a series of treatment milestones to characterize the activity and outcomes linked to level of factor deficiency correction. …”
Publicado 2019
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