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  1. 841
    por Bhatt, Arun
    Publicado 2010
    “…As the scientific advances continue to occur, there will be new ethical and regulatory challenges requiring dynamic updates in ethical and legal framework of clinical trials.…”
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    Evolution of Clinical Research: A History Before and Beyond James Lind
  2. 842
    por Kamel, Remah Moustafa
    Publicado 2013
    “…CONCLUSION: Although no other field in the medicine has integrated new knowledge into the daily practice more quickly than ART yet, there is a need for social research to counterbalance the dominance of biomedical one, in particular the people’s actual experiences and expectations of ART.…”
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    Assisted Reproductive Technology after the Birth of Louise Brown
  3. 843
    “…The development of protease inhibitors (PIs) such as telaprevir and boceprevir constitutes a milestone in chronic hepatitis C antiviral treatment since it has achieved sustained virological response (SVR) rates of up to 75% in naïve and 29-88% in treatment-experienced patients with genotype 1 infection. …”
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    Interferon-based combination treatment for chronic hepatitis C in the era of direct acting antivirals
  4. 844
    “…Its implementation will be a milestone in cervical cancer prevention and control. …”
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    Cervical cancer screening and treatment in Uganda
  5. 845
    “…Background and aim of the work: In 1803, the English physician Thomas Percival published Medical Ethics, a work destined to become a milestone in the development of modern codes of medical ethics, starting from the first edition of the American Medical Association’s ethical code. …”
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    Thomas Percival. Discussing the foundation of Medical Ethics
  6. 846
    “…In this perspective, we highlight milestones in the development and application of RNAi‐based methods to study carcinogenesis. …”
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    Cancer biology functional genomics: From small RNAs to big dreams
  7. 847
    “…Though challenging, individualized treatment based on the molecular characterization of the tumor should become the new standard of care. In the meantime, the success rate of clinical trials in oncology remains dramatically low. …”
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    Targeting tumor resistance mechanisms
  8. 848
    por Kurisaki, Ikuo, Tanaka, Shigenori
    Publicado 2021
    “…[Image: see text] Physicochemical characterization of multimeric biomacromolecule assembly and disassembly processes is a milestone to understand the mechanisms for biological phenomena at the molecular level. …”
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    Reaction Pathway Sampling and Free-Energy Analyses for Multimeric Protein Complex Disassembly by Employing Hybrid Configuration Bias Monte Carlo/Molecular Dynamics Simulation
  9. 849
    “…Background: Learning to cycle is an important milestone in a child’s life, so it is important to allow them to explore cycling as soon as possible. …”
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    Learning to Cycle: From Training Wheels to Balance Bike
  10. 850
    “…Understanding how exosomes interfere with chemoresistance may become a milestone in developing new therapeutic options, but more data are still required.…”
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    Small Extracellular Vesicles and Their Involvement in Cancer Resistance: An Up-to-Date Review
  11. 851
    “…Interesting activities consisting not only of changing the formulation but also modifying the drug molecule seem to be an important goal of the 21st century. ASA has become a milestone in two important fields: pharmacy and medicine. …”
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    Acetylsalicylic Acid–Primus Inter Pares in Pharmacology
  12. 852
    “…Global pressure from consumers to improve animal welfare, and reduce microbiological risks or the use of antibiotics pose new challenges for the meat industry. Today’s livestock production, despite many undertaken measures, is still far from being sustainable. …”
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    Sustainable Future Protein Foods: The Challenges and the Future of Cultivated Meat
  13. 853
    por Maher, Robert C
    Publicado 2018
    “…Outlines historical milestones in the field of audio forensics Features practical examples and recommendations Discusses research issues and challenges Includes practical guidelines for expert reports and testimony Covers digital audio signal processing for audio interpretation, intelligibility enhancement, and evaluation of authenticity.…”
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    Principles of forensic audio analysis
  14. 854
    “…ATLAS Computing Management has identified the migration of all computing resources to Harvester, PanDA’s new workload submission engine, as a critical milestone for Run 3 and 4. …”
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    Managing the ATLAS Grid through Harvester
  15. 855
    “…A better appreciation of the transporters present at the brain barriers will prove a valuable milestone in understanding the limited brain penetration of anti-HIV drugs in HIV and also aid the development of new anti-HIV drugs and drug combinations, with enhanced efficacy in the CNS. …”
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    The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research
  16. 856
    “…Countries used the opportunity to introduce new vaccines into their routine immunization. Populations, hitherto unreached with basic health services were reached with needed services, such as vitamin A supplementation, deworming, and catch up immunization services. …”
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    Five-year experience of African Vaccination Week implemented by the WHO Regional Office
  17. 857
    por Pigot, Corentin, Dumur, Frédéric
    Publicado 2019
    “…Following these initial works, an important milestone has been established with the formation of covalent bonds between molecules. …”
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    Recent Advances of Hierarchical and Sequential Growth of Macromolecular Organic Structures on Surface
  18. 858
    por Assas, Mushref Bakri
    Publicado 2021
    “…The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. …”
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    Anti-migraine agents from an immunological point of view
  19. 859
    “…Identification of a thymus-seeding progenitor originating from human bone marrow (BM) constitutes a key milestone in understanding the mechanisms of T cell development and provides new potential for correcting T cell deficiencies. …”
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    A human postnatal lymphoid progenitor capable of circulating and seeding the thymus
  20. 860
    “…Seven milestones related to diagnosis/treatment experiences were selected as outcomes. …”
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    Racial and Ethnic Differences in Timing of Diagnosis and Clinical Services Received in Duchenne Muscular Dystrophy
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