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901por Dhillon, Sohita“…This article summarizes the milestones in the development of ripretinib leading to this first approval for the treatment of advanced GIST.…”
Publicado 2020
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902“…In this review, we summarized the significant milestones in the preclinical discovery and clinical development of BTK inhibitors to better understand the clinical and commercial potential as well as the directions being taken. …”
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903“…Genetic analysis in hemophilia has tremendously improved in the last decades. Many new techniques and modifications as well as analysis softwares became available, which made the genetic analysis and interpretation of the data faster and more accurate. …”
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904por Tsiamis, Konstantinos, Palialexis, Andreas, Stefanova, Kremena, Gladan, Živana Ničević, Skejić, Sanda, Despalatović, Marija, Cvitković, Ivan, Dragičević, Branko, Dulčić, Jakov, Vidjak, Olja, Bojanić, Natalia, Žuljević, Ante, Aplikioti, Marilena, Argyrou, Marina, Josephides, Marios, Michailidis, Nikolas, Jakobsen, Hans H., Staehr, Peter A., Ojaveer, Henn, Lehtiniemi, Maiju, Massé, Cécile, Zenetos, Argyro, Castriota, Luca, Livi, Silvia, Mazziotti, Cristina, Schembri, Patrick J., Evans, Julian, Bartolo, Angela G., Kabuta, Saa Henry, Smolders, Sander, Knegtering, Edo, Gittenberger, Arjan, Gruszka, Piotr, Kraśniewski, Wojciech, Bartilotti, Cátia, Tuaty-Guerra, Miriam, Canning-Clode, João, Costa, Ana C., Parente, Manuela I., Botelho, Andrea Z., Micael, Joana, Miodonski, Joana V., Carreira, Gilberto P., Lopes, Vera, Chainho, Paula, Barberá, Carmen, Naddafi, Rahmat, Florin, Ann-Britt, Barry, Peter, Stebbing, Paul D., Cardoso, Ana Cristina“…The refined baseline inventories constitute a milestone for the MSFD Descriptor 2 implementation, providing an improved basis for reporting new NIS introductions, facilitating the MSFD D2 assessment. …”
Publicado 2019
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905por Overbeek, Ross, Begley, Tadhg, Butler, Ralph M., Choudhuri, Jomuna V., Chuang, Han-Yu, Cohoon, Matthew, de Crécy-Lagard, Valérie, Diaz, Naryttza, Disz, Terry, Edwards, Robert, Fonstein, Michael, Frank, Ed D., Gerdes, Svetlana, Glass, Elizabeth M., Goesmann, Alexander, Hanson, Andrew, Iwata-Reuyl, Dirk, Jensen, Roy, Jamshidi, Neema, Krause, Lutz, Kubal, Michael, Larsen, Niels, Linke, Burkhard, McHardy, Alice C., Meyer, Folker, Neuweger, Heiko, Olsen, Gary, Olson, Robert, Osterman, Andrei, Portnoy, Vasiliy, Pusch, Gordon D., Rodionov, Dmitry A., Rückert, Christian, Steiner, Jason, Stevens, Rick, Thiele, Ines, Vassieva, Olga, Ye, Yuzhen, Zagnitko, Olga, Vonstein, Veronika“…In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. …”
Publicado 2005
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906por CERN. Geneva. The LHC experiments Committee“…Finally, we describe the costing and schedule, including major milestones, to construct the detector.…”
Publicado 2017
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907por Tosciri, Cecilia“…The discovery in 2012 of the Higgs boson at the Large Hadron Collider (LHC) represents a milestone for the Standard Model (SM) of particle physics. …”
Publicado 2020
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908por Bhadauria, Archana Singh, Dhungana, Hom Nath, Verma, Vinay, Woodcock, Stephen, Rai, Tapan“…Indian National Strategic Plan 2017–2025, sets out the government plans to eliminate TB by 2025. However, the milestone seems unrealistic to achieve the TB eradication goal by 2025. …”
Publicado 2023
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909“…The management of acute pancreatitis has evolved. New research on the impact of electrolytes, pharmacologic agents, the role of anticoagulants, and nutrition support will provide scientific and clinical evidence to improve patient care and decrease morbidity and mortality.…”
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910por Strobl, Walter, Theologis, Tim, Brunner, Reinald, Kocer, Serdar, Viehweger, Elke, Pascual-Pascual, Ignacio, Placzek, Richard“…Individualised assessment and treatment are essential, and should be part of an integrated approach chosen to support the achievement of motor milestones. To this end, goals should be set for both the long term and for each injection cycle. …”
Publicado 2015
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911por Smith, David Roy“…The year 2014 saw more than a thousand new mitochondrial genome sequences deposited in GenBank—an almost 15% increase from the previous year. …”
Publicado 2016
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912“…SETD6 catalytic blockage by the peptide was also observed in cells upon treatment with the vp22-RelA302-316, resulting in induced cellular migration and proliferation. This new insight into the activity of a methylation inhibitory peptide could represent a milestone in the development of therapeutic tools, which can be of use in physiological cases where administration of cell proliferation is required.…”
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913“…In particular, two notable milestones have been reached in the assessment of TRPM7 druggability. …”
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914por Du, Xiaojing, Yang, Biwei, An, Quanlin, Assaraf, Yehuda G., Cao, Xin, Xia, Jinglin“…Indeed, the clinical success of these TKIs constitutes a critical milestone in targeted cancer therapy. Three generations of EGFR-TKIs are currently approved for the treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC). …”
Publicado 2021
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915“…CVs create new data-rich environments and are considered key enablers for many applications and services that will make our roads safer, less congested, and more eco-friendly. …”
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916“…Due to the complexity of the marine environment, researchers considered it as a new field to search for compounds with therapeutic efficacy, marine sponges represents the milestone in the discovery of unique compounds of potent activities against parasitic infections. …”
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917por Zhang, Fan-shun, He, Qing-ze, Qin, Chengxue Helena, Little, Peter J., Weng, Jian-ping, Xu, Suo-wen“…COLCOT and LoDoCo2 are two milestone clinical trials that confirm the curative effect of long-term administration of colchicine in reducing the incidence of cardiovascular events in patients with coronary artery disease. …”
Publicado 2022
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918por Goldstein Ferber, Sari, Weller, Aron, Ben-Shachar, Michal, Klinger, Gil, Geva, Ronny“…These occur in developmental milestones detectable in the same time windows (sensitive periods of development) within a convergent systematic progress. …”
Publicado 2022
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919por Gendia, Ahmed“…Additionally, AI plays an important role in all three platforms by providing time-based analysis of steps and highlighting critical milestones. Conclusion: Cloud-based AI-driven video analytics is an emerging new technology that enables users to store, analyze, and review videos. …”
Publicado 2022
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920por Boaro, A., Moscolo, F., Feletti, A., Polizzi, G.M.V., Nunes, S., Siddi, F., Broekman, M.L.D., Sala, F.“…Augmented reality technologies, with their ability to bring digital information into the real environment, have the potential to provide a new, revolutionary perspective to the neurosurgeon. …”
Publicado 2022
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