“…In 2010, a major scientific milestone was achieved for tree fruit crops: publication of the first draft whole genome sequence (WGS) for apple (Malus domestica). …”
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“…Ongoing studies continue to discover new antigens with superior tumor selectivity and defined function in regulating the pathophysiology of myeloma cells directly or indirectly in the immunosuppressive bone marrow microenvironment. …”
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“…This is a brief report on the establishment of a new program in New York State prisons to prepare prisoners to avoid the increased risks of drug overdose death associated with the transition to the community by training them in overdose prevention and making available naloxone, a medication that quickly reverses the effects of an opioid overdose, to all prisoners as they re-enter the community. …”
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“…These models were combined with the PfPR map to create new global predictions of PfEIR and PfR. All output maps included measured uncertainty. …”
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“…In this review, we will explain how and why VEN works, summarize its remarkable pathway to regulatory approval, and highlight the key milestones that have been important for its successful development in AML. …”
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“…In this study, training practices of racing greyhounds were described by New Zealand trainers using a pro forma survey. We found that trainers considered similar factors, (1) the ability to reach time milestones and (2) the appearance of young dogs, which indicated when they were ready to begin formal race training and racing, to be important when training young greyhounds. …”
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“…Some of the many pathophysiological mechanisms involved in the development of NAFLD include oxidative stress, impaired mitochondrial metabolism, inflammation, gut microbiota, and interaction between the brain-liver-axis and the regulation of hepatic lipid metabolism. The new therapeutic approaches in the treatment of NAFLD are targeting some of these milestones along the pathophysiological pathway and include drugs like agonists of peroxisome proliferator-activated receptors (PPARs), glucagon-like peptide-1 (GLP-1) agonists, sodium/glucose transport protein 2 (SGLT2) inhibitors, farnesoid X receptor (FXR) agonists, probiotics, and symbiotics. …”
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“…Finally, the latest publications referencing the enlarged panel of new biological targets for AD related to the microglia are highlighted. …”
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“…Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic milestone exerting a synthetic lethal effect in the treatment of cancer involving BRCA1/2 mutation. …”
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“…Particulary the introduction of the retrograde technique was a milestone. New developed microcatheters and special polymer coated wires allow to recanalize via small collaterals and vessels. …”
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“…The therapeutic targeting of the programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) axis marked a milestone in the treatment of non-small cell lung cancer (NSCLC), leading to unprecedented response duration and long-term survival for a relevant subgroup of patients affected by non-oncogene-addicted, metastatic disease. …”
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“…The AWAKE experiment reached all planned milestones during Run 1 (2016-18), notably the demonstration of strong plasma wakes generated by proton beams and the acceleration of externally injected electrons to multi-GeV energy levels in the proton driven plasma wakefields. …”
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“…BACKGROUND: The treatment of non-small-cell lung carcinoma (NSCLC) has changed markedly in recent years as a result of two major treatment milestones: Targeted therapy and immunotherapy. Since 2015, immunotherapy has been changing the paradigm of NSCLC treatment in different settings and has contributed to improve the quality of life of these patients. …”
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“…Many of the cited work are regarded as milestones in the EV field of research drawing a promising perspective for future EV studies. …”
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