Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines

por Hensler, Michal, Rakova, Jana, Kasikova, Lenka, Lanickova, Tereza, Pasulka, Josef, Holicek, Peter, Hraska, Marek, Hrnciarova, Tereza, Kadlecova, Pavla, Schoenenberger, Andreu, Sochorova, Klara, Rozkova, Daniela, Sojka, Ludek, Drozenova, Jana, Laco, Jan, Horvath, Rudolf, Podrazil, Michal, Hongyan, Guo, Brtnicky, Tomas, Halaska, Michal J., Rob, Lukas, Ryska, Ales, Coosemans, An, Vergote, Ignace, Garg, Abhishek D., Cibula, David, Bartunkova, Jirina, Spisek, Radek, Fucikova, Jitka
Publicado 2022

HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

por Foo, Caroline S., Abdelnabi, Rana, Kaptein, Suzanne J.F., Zhang, Xin, ter Horst, Sebastiaan, Mols, Raf, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Leyssen, Pieter, Dallmeier, Kai, Vergote, Valentijn, Heylen, Elisabeth, Vangeel, Laura, Chatterjee, Arnab K., Annaert, Pieter P., Augustijns, Patrick F., De Jonghe, Steven, Jochmans, Dirk, Gouwy, Mieke, Cambier, Seppe, Vandooren, Jennifer, Proost, Paul, van Laer, Christine, Weynand, Birgit, Neyts, Johan
Publicado 2022

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice

por Houweling, Arjan C., Beaman, Glenda M., Postma, Alex V., Gainous, T. Blair, Lichtenbelt, Klaske D., Brancati, Francesco, Lopes, Filipa M., van der Made, Ingeborg, Polstra, Abeltje M., Robinson, Michael L., Wright, Kevin D., Ellingford, Jamie M., Jackson, Ashley R., Overwater, Eline, Genesio, Rita, Romano, Silvio, Camerota, Letizia, D’Angelo, Emanuela, Meijers-Heijboer, Elizabeth J., Christoffels, Vincent M., McHugh, Kirk M., Black, Brian L., Newman, William G., Woolf, Adrian S., Creemers, Esther E.
Publicado 2019

Primrose syndrome: Characterization of the phenotype in 42 patients

por Melis, Daniela, Carvalho, Daniel, Barbaro‐Dieber, Tina, Espay, Alberto J., Gambello, Michael J., Gener, Blanca, Gerkes, Erica, Hitzert, Marrit M., Hove, Hanne B., Jansen, Sandra, Jira, Petr E., Lachlan, Katherine, Menke, Leonie A., Narayanan, Vinodh, Ortiz, Damara, Overwater, Eline, Posmyk, Renata, Ramsey, Keri, Rossi, Alessandro, Sandoval, Renata Lazari, Stumpel, Constance, Stuurman, Kyra E., Cordeddu, Viviana, Turnpenny, Peter, Strisciuglio, Pietro, Tartaglia, Marco, Unger, Sheela, Waters, Todd, Turnbull, Clare, Hennekam, Raoul C.
Publicado 2020

The rationale of opportunistic bilateral salpingectomies (OBS) during benign gynaecological and obstetric surgery: a consensus text of the Flemish Society of Obstetrics and Gynaeco...

por Tjalma, WAA, Bosteels, JJA, Cooremans, I, Cosyns, S, De Greve, M, De Vree, BP, Debruyne, D, De Jonge, ET, Desmedt, EJI, Dubois, P, Faes, T, Francx, M, Hamerlynck, T, Makar, AP, Maryns, AS, Michiels, I, Orye, G, Platteeuw, L, Pouseele, B, Schutyser, V, Segaert, A, Stevens, M, Tomassetti, C, Trinh, XB, Tummers, P, van Calenbergh, SGK, van Dam, PA, Van Herendael, B, Vanspauwen, R, Vergote, IB, Verguts, J, Watty, K, Weyers, S
Publicado 2019

Diagnostic value of radiological staging and surveillance for T1 colorectal carcinomas: A multicenter cohort study

por Huisman, Jelle F., Dang, Hao, Moons, Leon M. G., Backes, Yara, Dik, Vincent K., Groen, John N., ter Borg, Frank, van Bergeijk, Jeroen D., Geesing, Joost M. J., Spanier, B. W. Marcel, Terhaar Sive Droste, Joachim S., Overwater, Anouk, van Lelyveld, Niels, Kessels, Koen, Lacle, Miangela M., Offerhaus, G. Johan A., Brohet, Richard M., Knijn, Nikki, Vleggaar, Frank P., van Westreenen, Henderik L., de Vos tot Nederveen Cappel, Wouter H., Boonstra, Jurjen J.
Publicado 2023

Benign descriptors and ADNEX in two‐step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation in IOTA5 multicenter cohort

por Landolfo, C., Bourne, T., Froyman, W., Van Calster, B., Ceusters, J., Testa, A. C., Wynants, L., Sladkevicius, P., Van Holsbeke, C., Domali, E., Fruscio, R., Epstein, E., Franchi, D., Kudla, M. J., Chiappa, V., Alcazar, J. L., Leone, F. P. G., Buonomo, F., Coccia, M. E., Guerriero, S., Deo, N., Jokubkiene, L., Savelli, L., Fischerova, D., Czekierdowski, A., Kaijser, J., Coosemans, A., Scambia, G., Vergote, I., Timmerman, D., Valentin, L.
Publicado 2023

Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial

por Kurtz, Jean-Emmanuel, Pujade-Lauraine, Eric, Oaknin, Ana, Belin, Lisa, Leitner, Katharina, Cibula, David, Denys, Hannelore, Rosengarten, Ora, Rodrigues, Manuel, de Gregorio, Nikolaus, Martinez García, Jeronimo, Petru, Edgar, Kocián, Roman, Vergote, Ignace, Pautier, Patricia, Schmalfeldt, Barbara, Gaba, Lydia, Polterauer, Stephan, Mouret Reynier, Marie-Ange, Sehouli, Jalid, Churruca, Cristina, Selle, Frédéric, Joly, Florence, D'Hondt, Véronique, Bultot-Boissier, Émilie, Lebreton, Coriolan, Lotz, Jean-Pierre, Largillier, Rémy, Heudel, Pierre-Etienne, Heitz, Florian
Publicado 2023

Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study

por Van Calster, Ben, Valentin, Lil, Froyman, Wouter, Landolfo, Chiara, Ceusters, Jolien, Testa, Antonia C, Wynants, Laure, Sladkevicius, Povilas, Van Holsbeke, Caroline, Domali, Ekaterini, Fruscio, Robert, Epstein, Elisabeth, Franchi, Dorella, Kudla, Marek J, Chiappa, Valentina, Alcazar, Juan L, Leone, Francesco P G, Buonomo, Francesca, Coccia, Maria Elisabetta, Guerriero, Stefano, Deo, Nandita, Jokubkiene, Ligita, Savelli, Luca, Fischerová, Daniela, Czekierdowski, Artur, Kaijser, Jeroen, Coosemans, An, Scambia, Giovanni, Vergote, Ignace, Bourne, Tom, Timmerman, Dirk
Publicado 2020

Molecular Results and Potential Biomarkers Identified from the Phase 3 MILO/ENGOT-ov11 Study of Binimetinib versus Physician Choice of Chemotherapy in Recurrent Low-Grade Serous Ov...

por Grisham, Rachel N., Vergote, Ignace, Banerjee, Susana, Drill, Esther, Kalbacher, Elsa, Mirza, Mansoor Raza, Romero, Ignacio, Vuylsteke, Peter, Coleman, Robert L., Hilpert, Felix, Oza, Amit M., Westermann, Anneke, Oehler, Martin K., Pignata, Sandro, Aghajanian, Carol, Colombo, Nicoletta, Cibula, David, Moore, Kathleen N., del Campo, Josep M., Berger, Regina, Marth, Christian, Sehouli, Jalid, O'Malley, David M., Churruca, Cristina, Kristensen, Gunnar, Clamp, Andrew, Farley, John, Iyer, Gopa, Ray-Coquard, Isabelle, Monk, Bradley J.
Publicado 2023

MILO/ENGOT-ov11: Binimetinib Versus Physician’s Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum

por Monk, Bradley J., Grisham, Rachel N., Banerjee, Susana, Kalbacher, Elsa, Mirza, Mansoor Raza, Romero, Ignacio, Vuylsteke, Peter, Coleman, Robert L., Hilpert, Felix, Oza, Amit M., Westermann, Anneke, Oehler, Martin K., Pignata, Sandro, Aghajanian, Carol, Colombo, Nicoletta, Drill, Esther, Cibula, David, Moore, Kathleen N., Christy-Bittel, Janna, del Campo, Josep M., Berger, Regina, Marth, Christian, Sehouli, Jalid, O’Malley, David M., Churruca, Cristina, Boyd, Adam P., Kristensen, Gunnar, Clamp, Andrew, Ray-Coquard, Isabelle, Vergote, Ignace
Publicado 2020

Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Vali...

por Willing, Eva-Maria, Vollbrecht, Claudia, Vössing, Christine, Weist, Peggy, Schallenberg, Simon, Herbst, Johanna M., Schatz, Stefanie, Jóri, Balázs, Bataillon, Guillaume, Harter, Philipp, Salutari, Vanda, Martin, Antonio Gonzáles, Vergote, Ignace, Colombo, Nicoletta, Roeper, Julia, Berg, Tobias, Berger, Regina, Kah, Bettina, Noettrup, Trine Jakobi, Falk, Markus, Arndt, Kathrin, Polten, Andreas, Ray-Coquard, Isabelle, Selzam, Franziska, Pirngruber, Judith, Schmidt, Stefanie, Hummel, Michael, Tiemann, Markus, Horst, David, Sehouli, Jalid, Pujade-Lauraine, Eric, Tiemann, Katharina, Braicu, Elena Ioana, Heukamp, Lukas C.
Publicado 2023

HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

por Teschendorff, Andrew E., Lee, Shih-Han, Jones, Allison, Fiegl, Heidi, Kalwa, Marie, Wagner, Wolfgang, Chindera, Kantaraja, Evans, Iona, Dubeau, Louis, Orjalo, Arturo, Horlings, Hugo M., Niederreiter, Lukas, Kaser, Arthur, Yang, Winnie, Goode, Ellen L., Fridley, Brooke L., Jenner, Richard G., Berns, Els M.J.J., Wik, Elisabeth, Salvesen, Helga B., Wisman, G. Bea A., van der Zee, Ate G.J., Davidson, Ben, Trope, Claes G., Lambrechts, Sandrina, Vergote, Ignace, Calvert, Hilary, Jacobs, Ian J., Widschwendter, Martin
Publicado 2015

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

por Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Vande Velde, Greetje, Neyts, Johan, Rocha-Pereira, Joana, Delang, Leen
Publicado 2020

INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/...

por Colombo, N., Gadducci, A., Sehouli, J., Rulli, E., Mäenpää, J., Sessa, C., Montes, A., Ottevanger, N. B., Berger, R., Vergote, I., D’Incalci, M., Churruca Galaz, C., Chekerov, R., Nyvang, G. B., Riniker, S., Herbertson, R., Fossati, R., Barretina-Ginesta, M. P., Deryal, M., Mirza, M. R., Biagioli, E., Iglesias, M., Funari, G., Romeo, M., Tasca, G., Pardo, B., Tognon, G., Rubio-Pérez, M. J., DeCensi, A., De Giorgi, U., Zola, P., Benedetti Panici, P., Aglietta, M., Arcangeli, V., Zamagni, C., Bologna, A., Westermann, A., Heinzelmann-Schwarz, V., Tsibulak, I., Wimberger, P., Poveda, A.
Publicado 2023

Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study

por Thom, Ruth, Tipton, Thomas, Strecker, Thomas, Hall, Yper, Akoi Bore, Joseph, Maes, Piet, Raymond Koundouno, Fara, Fehling, Sarah Katharina, Krähling, Verena, Steeds, Kimberley, Varghese, Anitha, Bailey, Graham, Matheson, Mary, Kouyate, Saidou, Coné, Moussa, Moussa Keita, Balla, Kouyate, Sekou, Richard Ablam, Amento, Laenen, Lies, Vergote, Valentijn, Guiver, Malcolm, Timothy, Joseph, Atkinson, Barry, Ottowell, Lisa, Richards, Kevin S, Bosworth, Andrew, Longet, Stephanie, Mellors, Jack, Pannetier, Delphine, Duraffour, Sophie, Muñoz-Fontela, César, Sow, Oumou, Koivogui, Lamine, Newman, Edmund, Becker, Stephan, Sprecher, Armand, Raoul, Herve, Hiscox, Julian, Henao-Restrepo, Ana Maria, Sakoba, Keita, Magassouba, N'Faly, Günther, Stephan, Kader Konde, Mandy, Carroll, Miles W
Publicado 2020

Central Pathology Review in SENTIX, a Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2)

por Nemejcova, Kristyna, Kocian, Roman, Kohler, Christhardt, Jarkovsky, Jiri, Klat, Jaroslav, Berjon, Alberto, Pilka, Radovan, Sehnal, Borek, Gil-Ibanez, Blanca, Lupo, Ezequiel, Petiz, Almerinda, Arencibia Sanchez, Octavio, Kascak, Peter, Martinelli, Fabio, Buda, Alessandro, Presl, Jiri, Barahona, Marc, van Lonkhuijzen, Luc, Szatkowski, Wiktor, Minar, Lubos, Pakiz, Maja, Havelka, Pavel, Zorrero, Cristina, Misiek, Marcin, Snyman, Leon Cornelius, Wydra, Dariusz, Vergote, Ignace, Vinnytska, Alla, Redecha, Mikulas, Michal, Martin, Tingulstad, Solveig, Kipp, Barbara, Szewczyk, Grzegorz, Toth, Robert, de Santiago Garcia, Francisco Javier, Coronado Martin, Pluvio Jesus, Poka, Robert, Tamussino, Karl, Luyckx, Mathieu, Fastrez, Maxime, Staringer, Juan Carlos, Germanova, Anna, Plaikner, Andrea, Bajsova, Sylva, Dundr, Pavel, Mallmann-Gottschalk, Nina, Cibula, David
Publicado 2020

The diverse genetic origins of a Classical period Greek army

por Reitsema, Laurie J., Mittnik, Alissa, Kyle, Britney, Catalano, Giulio, Fabbri, Pier Francesco, Kazmi, Adam C. S., Reinberger, Katherine L., Sineo, Luca, Vassallo, Stefano, Bernardos, Rebecca, Broomandkhoshbacht, Nasreen, Callan, Kim, Candilio, Francesca, Cheronet, Olivia, Curtis, Elizabeth, Fernandes, Daniel, Lari, Martina, Lawson, Ann Marie, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Modi, Alessandra, Oppenheimer, Jonas, Özdogan, Kadir Toykan, Rohland, Nadin, Stewardson, Kristin, Vai, Stefania, Vergata, Chiara, Workman, J. Noah, Zalzala, Fatma, Zaro, Valentina, Achilli, Alessandro, Anagnostopoulos, Achilles, Capelli, Cristian, Constantinou, Varnavas, Lancioni, Hovirag, Olivieri, Anna, Papadopoulou, Anastasia, Psatha, Nikoleta, Semino, Ornella, Stamatoyannopoulos, John, Valliannou, Ioanna, Yannaki, Evangelia, Lazaridis, Iosif, Patterson, Nick, Ringbauer, Harald, Caramelli, David, Pinhasi, Ron, Reich, David
Publicado 2022

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

por Boudewijns, Robbert, Thibaut, Hendrik Jan, Kaptein, Suzanne J. F., Li, Rong, Vergote, Valentijn, Seldeslachts, Laura, Van Weyenbergh, Johan, De Keyzer, Carolien, Bervoets, Lindsey, Sharma, Sapna, Liesenborghs, Laurens, Ma, Ji, Jansen, Sander, Van Looveren, Dominique, Vercruysse, Thomas, Wang, Xinyu, Jochmans, Dirk, Martens, Erik, Roose, Kenny, De Vlieger, Dorien, Schepens, Bert, Van Buyten, Tina, Jacobs, Sofie, Liu, Yanan, Martí-Carreras, Joan, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Chiu, Winston, Leyssen, Pieter, Heylen, Elisabeth, Schols, Dominique, Wang, Lanjiao, Close, Lila, Matthijnssens, Jelle, Van Ranst, Marc, Compernolle, Veerle, Schramm, Georg, Van Laere, Koen, Saelens, Xavier, Callewaert, Nico, Opdenakker, Ghislain, Maes, Piet, Weynand, Birgit, Cawthorne, Christopher, Vande Velde, Greetje, Wang, Zhongde, Neyts, Johan, Dallmeier, Kai
Publicado 2020

Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: an international multicentre analysis

por May, Taymaa, Bernardini, Marcus, Lheureux, Stephanie, Aben, Katja K.H., Bandera, Elisa V., Beckmann, Matthias W., Benitez, Javier, Berchuck, Andrew, Bjørge, Line, Carney, Michael E., Cramer, Daniel W., deFazio, Anna, Dörk, Thilo, Eccles, Diana M., Friedlander, Michael, García, María Jose, Goode, Ellen L., Hein, Alexander, Høgdall, Claus K., Jensen, Allan, Johnatty, Sharon, Kennedy, Catherine J., Kiemeney, Lambertus A., Kjær, Susanne K., Kupryjańczyk, Jolanta, Matsuo, Keitaro, McGuire, Valerie, Modugno, Francesmary, Paddock, Lisa E., Pejovic, Tanja, Phelan, Catherine M., Riggan, Marjorie J., Rodriguez-Antona, Cristina, Rothstein, Joseph H., Sieh, Weiva, Song, Honglin, Terry, Kathryn L., van Altena, Anne M., Vanderstichele, Adriaan, Vergote, Ignace, Thomsen, Liv Cecilie Vestrheim, Webb, Penelope M., Wentzensen, Nicolas, Wilkens, Lynne R., Ziogas, Argyrios, Jiang, Haiyan, Tone, Alicia
Publicado 2023