“…Based on the overall findings, we postulate that furin likely plays a key role in regulating expression of cellular sialoglycans, which in turn can influence permissivity to AAVs and possibly other viruses. IMPORTANCE Adeno-associated viruses (AAVs) are a proven recombinant vector platform for gene therapy and have demonstrated success in the clinic. …”
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“…We used two technical approaches: the detection and quantification of viral genomic RNA using RT-qPCR, and virus infectivity using permissive in vitro Vero E6 culture. RESULTS: All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA but at dissimilar levels ranging from 1.01 × 10(2) copies/mL to 1.14 × 10(8) copies/mL, even among those cases who had been COVID-19 vaccinated. …”
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“…Here, we established the permissiveness of the rainbow trout intestinal cell line RTgutGC towards the important salmonid viruses—infectious pancreatic necrosis virus (IPNV), salmonid alphavirus (subtype 3, SAV3) and infectious salmon anemia virus (ISAV)—and explored the infection mechanisms of the three different viruses in these cells at different virus to cell ratios. …”
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“…K31 is well tolerated by SARS-CoV-2-permissive Caco2 cells. Our results show that K31 inhibited SARS-CoV-2 replication in Caco2 cells with a selective index of ~58. …”
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“…We previously reported that in mice, ghrelin is permissive for the usual CRR to insulin-induced hypoglycemia. …”
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“…METHODS: The pain scale was translated into Swedish by an accredited company, and permission was granted to use the resultant version. …”
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“…The mid gut microbial diversity analysis showed that dietary B. subtilis supplementation increased the abundance of probiotics such as Tenericutes and Bacteroides, whereas it reduced the abundance of pernicious bacteria such as Proteobacteria, Actinobacteria, Thermophilia and Spirochaetes. …”
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“…METHODS: The study was performed after obtaining permission from the judicial authorities and approval from the local ethics committee. …”
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“…The incumbent cooling system uses synthetic refrigerants (CFCs, HCFC, and HFCs) that outperform natural refrigerants but are banned or under time bared permission due to their harmful effects. The global community of (196 parties till 2017) has ratified Paris Accord to limit GHG emissions and use low Global Warming Potential (GWP) refrigerants, and after the ban on existing synthetic refrigerants, quested for suitable natural working fluids and retrofitting in the existing system. …”
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“…METHODS: This audit was registered with Audit & Service Evaluation Registration services at the Cambridgeshire and Peterborough NHS foundation trust (CPFT). The necessary permissions to access patient records on the trust's electronic patient record (EPR) system were obtained from appropriate authorities in the CPFT IT department. …”
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“…The modified process was conducted after granting permission from the original authors. The content validity of the modified index was examined by five experts. …”
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“…Digital immigrant educators with extreme responses were identified and asked permission for an interview. Open-access adapted questionnaires used were Simplified Coping Style Questionnaire (SCSQ), Beck Anxiety Inventory (BAI), Perceived Organizational Support (POS), Allen and Meyer’s Organizational Commitment Questionnaire (OCQ). …”
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“…The loss tangent was significantly reduced by an order of magnitude compared to that of the undoped composite, from tanδ∼0.161 to ∼0.016 at 1 kHz, while the dielectric permittivity slightly decreased from ε′∼5.7 × 10(3) to ∼4.0 × 10(3). …”
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“…In this study, comparative genomic analysis between Pc. cantorii and 16 other vertebrate genomes indicated that turtles separated from the ancestor of archosaurians approximately 256.6 (95% highest posterior density interval, 263.6–251.9) million years ago (Mya) (Upper Permian to Triassic) and that Pc. cantorii separated from the ancestor of Pd. sinensis and R. swinhoei approximately 59.3 (95% highest posterior density interval, 64.3–54.3) Mya. …”
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“…We compared the patterns of these effects by feeding Cheilomenes propinqua females on mixed diets: unlimited low-quality prey (eggs of the grain moth Sitotroga cerealella) and limited high-quality prey (the green peach aphid Myzus persicae: 0, 2, 10, and 50 aphids per day). About half of the females fed only on the grain moth eggs oviposited and their fecundity was very low. …”
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“…Gummosis is 1 of the most common and destructive diseases threatening global peach (Prunus persica) production. Our previous studies have revealed that ethylene and methyl jasmonate enhance peach susceptibility to Lasiodiplodia theobromae, a virulent pathogen inducing gummosis; however, the underlying molecular mechanisms remain obscure. …”
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“…After 7 days (p = 0.005) significant differences were found among the different mouthwashes, with those containing alcohol having significantly higher impact on the force decay than those containing chlorhexidine 0.2%, sodium fluoride or Persica. However, at 24 h (p = 0.200), 14 days (p = 0.076), 21 days (p = 0.120) and 28 days (p = 0.778) no statistically significant differences among the different mouthwashes were found, although those containing alcohol presented a strong tendency. …”
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“…Important was engaging the people who know the most—frontline staff and persons in need of care—in combination with permissive leadership and embracing quality improvement dimensions. …”
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“…Glioblastoma is a grade IV pernicious neoplasm occurring in the supratentorial region of brain. …”
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“…CONCLUSIONS: HMC demonstrated a significantly more permissive approach to both prescribing and consuming opioid medications for postoperative pain management than SMC for similar, common otolaryngological surgeries. …”
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