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160981por Cheung, Moira, Sakka, Sophia, Gilbey-Cross, Robyn, Harries, Mark, Mathieson, Leigh“…Patients must have also had an unsatisfactory response to best available care and treatment. EAP enrolment was between January and March 2018. A total of 142 applications were received of which 135 were approved with 132 receiving treatment to date.(1) Of the 7 declined, 4 failed to meet diagnostic criteria and 3 had insufficient radiological evidence.(1) Treatment, including, dose was in accordance with the EMA marketing authorisation. …”
Publicado 2019
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160982por Paes Batista da Silva, Paula, Pereira, Rosa, Takayama, Liliam, Borba, Clarissa, Duarte, Felipe, Trarbach, Ericka, Martin, Regina, Bronstein, Marcello, Tritos, Nicholas, Jallad, Raquel“…Bone microarchitecture was assessed by HR-pQCT at the distal radius and tíbia. We enrolled twenty six women with acromegaly (40.3± 5.8years,30.2 kg/m(2)) and 60 control subjects (40.6 ± 5.8 years, 28.4 ± 4.6 kg/m(2)), none of whom had hypopituitarism. …”
Publicado 2019
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160983“…Material and Methods: 805 men with hypogonadism are enrolled in a registry study in a urological office. 412 received TTh with TU 1000 mg/12 weeks (T-group) while 393 opted against TTh and served as controls (CTRL). 43 men (10.4%) in the T-group had Klinefelter’s syndrome and contributed to lowering the mean age of the treated group. …”
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160984por De Vincentis, Sara, Decaroli, Maria Chiara, Diazzi, Chiara, Santi, Daniele, Carli, Federica, Zona, Stefano, Guaraldi, Giovanni, Rochira, Vincenzo“…RESULTS: 1862 HIV-infected patients (1271 (68.3%) males and 591 (31.7%) females) were enrolled (mean age 46.3±7.8 years; average duration of HIV-infection 15.4±7.7 years). …”
Publicado 2019
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160985por Archer, David, Sitruk-Ware, Regine, Mirkin, Sebastian, Brache, Vivian, Merkatz, Ruth, Kumar, Narender“…A one-year segesterone acetate (SA)/ethinyl estradiol (EE) contraceptive vaginal system (CVS; Annovera™) used to prevent pregnancy in women of reproductive age, was recently approved by the FDA (August 2018). Efficacy (Pearl Index of 2.98) and safety of the CVS were demonstrated in two phase 3, open-label, multicenter studies conducted in the US and internationally. …”
Publicado 2019
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160986por McGlynn, Elizabeth A., Adams, John L., Kramer, Jason, Sahota, Amandeep K., Silverberg, Michael J., Shenkman, Elizabeth, Nelson, David R.“…Of 82 419 eligible adults, a total of 33 808 who met eligibility criteria (age, 18-88 years; HCV quantitative result or genotype from 2012 or later; continuously enrolled; naive to DAA treatment at baseline) were included. …”
Publicado 2019
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160987por Weil, Gary J., Bogus, Joshua, Christian, Michael, Dubray, Christine, Djuardi, Yenny, Fischer, Peter U., Goss, Charles W., Hardy, Myra, Jambulingam, Purushothaman, King, Christopher L., Kuttiat, Vijesh Sridhar, Krishnamoorthy, Kaliannagounder, Laman, Moses, Lemoine, Jean Frantz, O’Brian, Katiuscia K., Robinson, Leanne J., Samuela, Josaia, Schechtman, Kenneth B., Sircar, Anita, Srividya, Adinarayanan, Steer, Andrew C., Supali, Taniawati, Subramanian, Swaminathan“…A total of 26,836 persons were enrolled (13,535 females and 13,300 males). A total of 12,280 participants were treated with DA, and 14,556 were treated with IDA. …”
Publicado 2019
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160988por Javaid, Zaida, Imtiaz, Unaiza, Khalid, Imtiaz, Saeed, Hamid, Khan, Rehana Qadir, Islam, Muhammad, Saleem, Zikria, Sohail, Muhammad Farhan, Danish, Zeeshan, Batool, Farah, Anwer, Naveed“…METHODS: The first open label, randomized control trial conducted at a primary health care facility of Lahore, Pakistan by enrolling 244 uncontrolled type 2 diabetes (hemoglobin A1 c, (HbA1c); 10.85 ± 1.74) patients. …”
Publicado 2019
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160989por Palmqvist, Sebastian, Janelidze, Shorena, Stomrud, Erik, Zetterberg, Henrik, Karl, Johann, Zink, Katharina, Bittner, Tobias, Mattsson, Niklas, Eichenlaub, Udo, Blennow, Kaj, Hansson, Oskar“…Study participants were consecutively enrolled between July 6, 2009, and February 11, 2015 (cohort 1), and between January 29, 2000, and October 11, 2006 (cohort 2). …”
Publicado 2019
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160990por Okugawa, Yoshinaga, Toiyama, Yuji, Hur, Keun, Yamamoto, Akira, Yin, Chengzeng, Ide, Shozo, Kitajima, Takahito, Fujikawa, Hiroyuki, Yasuda, Hiromi, Koike, Yuhki, Okita, Yoshiki, Hiro, Junichiro, Yoshiyama, Shigeyuki, Araki, Toshimitsu, Miki, Chikao, McMillan, Donald C., Goel, Ajay, Kusunoki, Masato“…RESULTS: A total of 183 patients (108 men and 75 women) were included. The median age of enrolled patients at diagnosis was 68.0 years (range 35–89 years). …”
Publicado 2019
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160991“…METHODS: All consecutive STEMI patients candidate for PPCI and admitted to Critical Care Department, Cairo University hospitals, managed either by thrombectomy before primary PCI (if thrombus score ≥ 3) or conventional PPCI, Six hundred seven subjects were enrolled in the study divided into Group with thrombectomy before PPCI (107 subjects, 18%), and group with Conventional PCI (500 subjects, 82%). …”
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160992“…Before the operation, computer optometry, best corrected visual acuity, intraocular pressure, slit lamp, gonioscopy, preset lens, A-mode ultrasonography, and UBM were performed. All the enrolled subjects underwent cataract surgery with or without other operations. …”
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160993por Ross, Jonathan D C, Brittain, Clare, Cole, Michelle, Dewsnap, Claire, Harding, Jan, Hepburn, Trish, Jackson, Louise, Keogh, Matthew, Lawrence, Tessa, Montgomery, Alan A, Roberts, Tracy E, Sprange, Kirsty, Tan, Wei, Thandi, Sukhwinder, White, John, Wilson, Janet, Duley, Lelia“…FINDINGS: Of 1762 patients assessed, we enrolled 720 participants between Oct 7, 2014, and Nov 14, 2016, and randomly assigned 358 to gentamicin and 362 to ceftriaxone. …”
Publicado 2019
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160994por Topalian, Suzanne L., Hodi, F. Stephen, Brahmer, Julie R., Gettinger, Scott N., Smith, David C., McDermott, David F., Powderly, John D., Sosman, Jeffrey A., Atkins, Michael B., Leming, Philip D., Spigel, David R., Antonia, Scott J., Drilon, Alexander, Wolchok, Jedd D., Carvajal, Richard D., McHenry, M. Brent, Hosein, Fareeda, Harbison, Christopher T., Grosso, Joseph F., Sznol, Mario“…DESIGN, SETTING, AND PARTICIPANTS: This was a secondary analysis of the phase 1 CA209-003 trial (with expansion cohorts), which was conducted at 13 US medical centers and included 270 patients with advanced melanoma, RCC, or NSCLC who received nivolumab and were enrolled between October 30, 2008, and December 28, 2011. …”
Publicado 2019
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160995por Dyrbye, Liselotte, Herrin, Jeph, West, Colin P., Wittlin, Natalie M., Dovidio, John F., Hardeman, Rachel, Burke, Sara Emily, Phelan, Sean, Onyeador, Ivuoma Ngozi, Cunningham, Brooke, van Ryn, Michelle“…Participants were followed up from enrollment in 2010 to 2011 through 2017. Participants completed questionnaires at year 4 of medical school as well as at the second and third years of residency. …”
Publicado 2019
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160996por Trent, Maria, Perin, Jamie, Gaydos, Charlotte A., Anders, Jennifer, Chung, Shang-en, Tabacco Saeed, Lisa, Rowell, Julia, Huettner, Steven, Rothman, Richard, Butz, Arlene“…This study compared the efficacy of the intervention with that of the standard of care using an intention-to-treat analysis. INTERVENTIONS: Enrolled participants completed an audio computer-assisted self-interview, provided specimens for N gonorrhoeae and C trachomatis testing, and were randomized to standard treatment (n = 137) or the TECH-N intervention (n = 149). …”
Publicado 2019
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160997por Yende, Sachin, Kellum, John A., Talisa, Victor B., Peck Palmer, Octavia M., Chang, Chung-Chou H., Filbin, Michael R., Shapiro, Nathan I., Hou, Peter C., Venkat, Arvind, LoVecchio, Frank, Hawkins, Katrina, Crouser, Elliott D., Newman, Anne B., Angus, Derek C.“…DESIGN, SETTINGS, AND PARTICIPANTS: This prospective, multicenter cohort study enrolled and followed up for 1 year adults who survived a hospitalization for sepsis from January 10, 2012, to May 25, 2017, at 12 US hospitals. …”
Publicado 2019
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160998“…RESULTS: A total of 102 patients were enrolled, with two patients excluded. Demographic characteristics were similar among the three groups. …”
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160999por Hansen, Bjarke Brandt, Kirkeskov, Lilli, Begtrup, Luise Moelenberg, Boesen, Mikael, Bliddal, Henning, Christensen, Robin, Andreasen, Ditte Lundsgaard, Kristensen, Lars Erik, Flachs, Esben Meulengracht, Kryger, Ann Isabel“…METHODS AND FINDINGS: We enrolled people from the capital region of Denmark to an open-label, parallel-group randomized controlled trial with a superiority design from March 2014 through December 2015. …”
Publicado 2019
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161000Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canadapor Green, Rivka, Lanphear, Bruce, Hornung, Richard, Flora, David, Martinez-Mier, E. Angeles, Neufeld, Raichel, Ayotte, Pierre, Muckle, Gina, Till, Christine“…RESULTS: Of 512 mother-child pairs, the mean (SD) age for enrollment for mothers was 32.3 (5.1) years, 463 (90%) were white, and 264 children (52%) were female. …”
Publicado 2019
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