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161141por Wang, Hao, Tang, Han, Fang, Yong, Tan, Lijie, Yin, Jun, Shen, Yaxing, Zeng, Zhaochong, Zhu, Jiangyi, Hou, Yingyong, Du, Ming, Jiao, Jia, Jiang, Hongjing, Gong, Lei, Li, Zhigang, Liu, Jun, Xie, Deyao, Li, Wenfeng, Lian, Changhong, Zhao, Qiang, Chen, Chun, Zheng, Bin, Liao, Yongde, Li, Kuo, Li, Hecheng, Wu, Han, Dai, Liang, Chen, Ke-Neng“…From January 1, 2017, to December 31, 2018, 264 patients with ESCC of clinical stages from cT3 to T4aN0 to 1M0 were enrolled. Analysis was performed on an intention-to-treat basis from January 1, 2017, to August 30, 2020. …”
Publicado 2021
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161142por van der Kooi, Anne-Lotte L F, van Dijk, Marloes, Broer, Linda, van den Berg, Marleen H, Laven, Joop S E, van Leeuwen, Flora E, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, van der Pal, Helena J, Tissing, Wim J, Versluys, Birgitta, Bresters, Dorine, Beerendonk, Catharina C M, Ronckers, Cécile R, van der Heiden-van der Loo, Margriet, Kaspers, Gertjan L, de Vries, Andrica C H, Robison, Leslie L, Hudson, Melissa M, Chemaitilly, Wassim, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D, Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kruseova, Jarmila, Modan-Moses, Dalit, Pluijm, Saskia M F, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H, Kremer, Leontien C, Yasui, Yutaka, Brooke, Russell J, Uitterlinden, André G, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline“…Female 5-year CCS, diagnosed with cancer and treated with chemotherapy before the age of 25 years, and aged 18 years or older at time of study were enrolled in the current study. Results from the discovery Dutch DCOG-LATER VEVO cohort (n = 285) were validated in the pan-European PanCareLIFE (n = 465) and the USA-based St. …”
Publicado 2021
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161143Publicado 2021“…The azithromycin group enrolled participants between May 22 and Nov 30, 2020, by which time 2265 participants had been randomly assigned, 540 to azithromycin plus usual care, 875 to usual care alone, and 850 to other interventions. 2120 (94%) of 2265 participants provided follow-up data and were included in the Bayesian primary analysis, 500 participants in the azithromycin plus usual care group, 823 in the usual care alone group, and 797 in other intervention groups. 402 (80%) of 500 participants in the azithromycin plus usual care group and 631 (77%) of 823 participants in the usual care alone group reported feeling recovered within 28 days. …”
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161144por Yao, Can, Wang, Lingwei, Shi, Fei, Chen, Rongchang, Li, Binbin, Liu, Wenwen, Feng, Mengjie, Li, Sinian“…A total of 146 cases of AECOPD complicated with HF were enrolled and classified into survivor group (n=94) and non-survivor group (n=52). …”
Publicado 2021
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161145por Fujihashi, Takahide, Sakata, Yasuhiko, Nochioka, Kotaro, Miura, Masanobu, Abe, Ruri, Kasahara, Shintaro, Sato, Masayuki, Aoyanagi, Hajime, Yamanaka, Shinsuke, Hayashi, Hideka, Shiroto, Takashi, Sugimura, Koichiro, Takahashi, Jun, Miyata, Satoshi, Shimokawa, Hiroaki“…METHODS AND RESULTS: In the Chronic Heart Failure Registry and Analysis in the Tohoku District‐2 (CHART‐2) study, we enrolled 4652 consecutive patients with CHF and classified them into four groups based on baseline serum UA levels by the Classification and Regression Tree: G1 (<3.8 mg/dL, N = 313), G2 (3.8–7.1 mg/dL, N = 3070), G3 (7.2–9.2 mg/dL, N = 1018), and G4 (>9.2 mg/dL, N = 251). …”
Publicado 2020
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161146por Kappos, Ludwig, Fox, Robert J., Burcklen, Michel, Freedman, Mark S., Havrdová, Eva K., Hennessy, Brian, Hohlfeld, Reinhard, Lublin, Fred, Montalban, Xavier, Pozzilli, Carlo, Scherz, Tatiana, D'Ambrosio, Daniele, Linscheid, Philippe, Vaclavkova, Andrea, Pirozek-Lawniczek, Magdalena, Kracker, Hilke, Sprenger, Till“…DESIGN, SETTING, AND PARTICIPANTS: This multicenter, double-blind, active-comparator, superiority randomized clinical trial enrolled patients from April 27, 2015, to May 16, 2019, who were aged 18 to 55 years and had been diagnosed with multiple sclerosis per 2010 McDonald criteria, with a relapsing course from the onset, Expanded Disability Status Scale (EDSS) scores of 0 to 5.5, and recent clinical or magnetic resonance imaging disease activity. …”
Publicado 2021
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161147por Emary, Katherine R W, Golubchik, Tanya, Aley, Parvinder K, Ariani, Cristina V, Angus, Brian, Bibi, Sagida, Blane, Beth, Bonsall, David, Cicconi, Paola, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Cox, Tony, Darton, Thomas C, Dold, Christina, Douglas, Alexander D, Duncan, Christopher J A, Ewer, Katie J, Flaxman, Amy L, Faust, Saul N, Ferreira, Daniela M, Feng, Shuo, Finn, Adam, Folegatti, Pedro M, Fuskova, Michelle, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hallis, Bassam, Heath, Paul T, Hay, Jodie, Hill, Helen C, Jenkin, Daniel, Kerridge, Simon, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Ludden, Catherine, Marchevsky, Natalie G, Minassian, Angela M, McGregor, Alastair C, Mujadidi, Yama F, Phillips, Daniel J, Plested, Emma, Pollock, Katrina M, Robinson, Hannah, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sutherland, Rebecca K, Thomson, Emma C, Toshner, Mark, Turner, David P J, Vekemans, Johan, Villafana, Tonya L, Williams, Christopher J, Hill, Adrian V S, Lambe, Teresa, Gilbert, Sarah C, Voysey, Merryn, Ramasamy, Maheshi N, Pollard, Andrew J“…METHODS: Volunteers (aged ≥18 years) who were enrolled in phase 2/3 vaccine efficacy studies in the UK, and who were randomly assigned (1:1) to receive ChAdOx1 nCoV-19 or a meningococcal conjugate control (MenACWY) vaccine, provided upper airway swabs on a weekly basis and also if they developed symptoms of COVID-19 disease (a cough, a fever of 37·8°C or higher, shortness of breath, anosmia, or ageusia). …”
Publicado 2021
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161148“…Using the casefiles of 376 school children registered in a Mental Health and Psychosocial Support (MHPSS) project in the Northwest governorate of Idleb in Syria, this study aimed to determine (i) the rates of various protection concerns (potential mental health conditions, psychosocial deprivation issues, and social, behavioural and emotional issues) for students enrolled in this project, (ii) whether the rates of any of the protection concerns varied between children and adolescents, or between boys and girls, and (iii) which of the identified demographic and protection sector factors predicted the presence of potential mental health conditions and MHPSS intervention outcomes. …”
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161149“…METHODS: A total of 71 patients with a mean age of 28.85 years (range, 13.58-61.31 years) were enrolled, with 58 patients submitting sufficient pre- and postoperative blood samples for HLA antibody testing. …”
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161150“…RESULTS: In total, there were 4 studies including 1547 patients who met the eligibility criteria and enrolled. For indirect comparisons, no significant difference on PFS was observed between atezolizumab and durvalumab (HR 0.96, 95% CI, 0.72–1.29), or between atezolizumab and pembrolizumab (HR 1.05, 95% CI, 0.78–1.43), or between atezolizumab and nivolumab (HR 1.18, 95% CI, 0.79–1.79), or between durvalumab and pembrolizumab (HR 1.10, 95% CI, 0.84–1.43). or between durvalumab and nivolumab (HR 1.23, 95% CI, 0.83–1.82), or between pembrolizumab and nivolumab (HR 1.12, 95% CI, 0.76–1.66), nor significant difference on OS observed between atezolizumab and durvalumab (HR 0.93, 95% CI, 0.67–1.30), or between atezolizumab and pembrolizumab (HR 0.88, 95% CI, 0.62–1.24), or between atezolizumab and nivolumab (HR 1.04, 95% CI, 0.66–1.66), or between durvalumab and pembrolizumab (HR 0.94, 95% CI, 0.70–1.25), or between durvalumab and nivolumab (HR 1.12, 95% CI, 0.73–1.71), or between pembrolizumab and nivolumab (HR 1.19, 95% CI, 0.77–1.84). …”
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161151por El Rhalete, Abdelilah, Rhazi, Inas, Bensaid, Amine, Zaid, Ikram, Bkiyer, Houssam, Ismaili, Nabila, Elouafi, Nouha, Housni, Brahim“…Lung damage from COVID-19 was extensive in 27.38%, severe in 32.14%, and critical in 40.47% of enrolled cases. CT chest angiography, ECG, and cardiac ultrasound were performed to the paraclinical confirmatory exploration of cardiac damages of these patients. …”
Publicado 2021
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161152por Rikken, J F W, Kowalik, C R, Emanuel, M H, Bongers, M Y, Spinder, T, Jansen, F W, Mulders, A G M G J, Padmehr, R, Clark, T J, van Vliet, H A, Stephenson, M D, van der Veen, F, Mol, B W J, van Wely, M, Goddijn, M“…TRIAL REGISTRATION NUMBER: Dutch trial registry: NTR 1676 TRIAL REGISTRATION DATE: 18 February 2009 DATE OF FIRST PATIENT’S ENROLMENT: 20 October 2010…”
Publicado 2021
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161153por Mdege, Noreen Dadirai, Fairhurst, Caroline, Wang, Han-I, Ferdous, Tarana, Marshall, Anna-Marie, Hewitt, Catherine, Huque, Rumana, Jackson, Cath, Kellar, Ian, Parrott, Steve, Semple, Sean, Sheikh, Aziz, Wu, Qi, Azdi, Zunayed Al, Siddiqi, Kamran“…FINDINGS: Between April 11 and Aug 2, 2018, we enrolled 1801 households from 45 mosques. 640 households (35·5%) were assigned to the smoke-free-home intervention plus indoor-air-quality feedback group, 560 (31·1%) to the smoke-free-home intervention only group, and 601 (33·4%) to the usual services group. …”
Publicado 2021
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161154por Krishnakumar, Arjun, Verma, Ritika, Chawla, Rajeev, Sosale, Aravind, Saboo, Banshi, Joshi, Shilpa, Shaikh, Maaz, Shah, Abhishek, Kolwankar, Siddhesh, Mattoo, Vinod“…METHODS: We analyzed deidentified data from 102 patients with T2D from India enrolled in a 16-week structured self-management program delivered using the Wellthy CARE mobile app. …”
Publicado 2021
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161155por Mollan, Susan P., Mitchell, James L., Ottridge, Ryan S., Aguiar, Magda, Yiangou, Andreas, Alimajstorovic, Zerin, Cartwright, David M., Grech, Olivia, Lavery, Gareth G., Westgate, Connar S. J., Vijay, Vivek, Scotton, William, Wakerley, Ben R., Matthews, Tim D., Ansons, Alec, Hickman, Simon J., Benzimra, James, Rick, Caroline, Singhal, Rishi, Tahrani, Abd A., Brock, Kristian, Frew, Emma, Sinclair, Alexandra J.“…DESIGN, SETTING, AND PARTICIPANTS: This 5-year randomized clinical trial (Idiopathic Intracranial Hypertension Weight Trial) enrolled women with active IIH and a body mass index (calculated as weight in kilograms divided by height in meters squared) of 35 or higher at 5 National Health Service hospitals in the UK between March 1, 2014, and May 25, 2017. …”
Publicado 2021
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161156por Macy, Eric, McCormick, Thomas A., Adams, John L., Crawford, William W., Nguyen, Myngoc T., Hoang, Liem, Eng, Victoria, Davis, Anna C., McGlynn, Elizabeth A.“…Of 4 398 792 patients, 4 206 480 met the eligibility criteria: enrollment in the health system during antibiotic use, availability of complete demographic data, and use of antibiotics outside of the washout period. …”
Publicado 2021
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161157por Frias, Juan Pablo, Lawitz, Eric J, Ortiz-LaSanta, Grisell, Franey, Bridgette, Morrow, Linda, Chen, Chao-Yin, Tseng, Leo, Charlton, R William, Mansbach, Hank, Margalit, Maya, Loomba, Rohit“…Methods: This Phase 1b/2a trial enrolled 81 subjects with liver fat ≥10% by MRI-PDFF and either biopsy-confirmed NASH (BC-NASH) or phenotypic NASH (PNASH: central obesity with either type 2 diabetes mellitus or with evidence of liver injury by ALT or FibroScan vibration controlled transient elastography score above defined thresholds). …”
Publicado 2021
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161158“…Results: Of the 124 patients enrolled in the study, 99 were <18 years old and 103 were taking growth hormone (GH). …”
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161159por Leboulleux, Sophie, Cao, Christine Do, Zerdoud, Slimane, Attard, Marie, Bournaud, Claire, Benisvy, Danielle, Taieb, David, Bardet, Stephane, Terroir-Cassou-Mounat, Marie, Betrian, Sarah, Lion, Georges, Schiazza, Aurelie, Sajous, Christophe, Garcia, Marie-Eve, Schlumberger, Martin Jean, Godbert, Yann, Borget, Isabelle“…Methods: Patients with BRAFV600E mutated RAIR metastatic DTC with RECIST progression within 18 months prior to enrollment and no lesion > 3 cm were included. A baseline rhTSH-stimulated diagnostic whole body scan (dc WBS) was performed prior to treatment initiation. …”
Publicado 2021
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161160por Hassanein, Mohamed, Sahay, Rakesh Kumar, Malek, Rachid, Shaltout, Inass, Djaballah, Khier, Demil, Nacima, Chao, Jason, Andersson, Helena M, Buyukbese, Mehmet Akif, Sifri, Saud Al“…Adults with T2D who had taken iGlarLixi for ≥3 months before inclusion and who planned to fast for ≥15 days during Ramadan, were enrolled from 5 countries. During the study, iGlarLixi treatment was adjusted as per routine practice by the treating physician. …”
Publicado 2021
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