“…DESIGN, SETTING, AND PARTICIPANTS: This retrospective comparative effectiveness cohort study used deidentified Medicare claims data from August 1, 2014, to September 30, 2018, with follow-up from drug initiation until treatment changes, death, or gap in Medicare enrollment (>30 days). Data analysis was performed from October 1, 2021, to April 30, 2022. …”
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“…TRIAL REGISTRATION NUMBER: Dutch Trial register NL5455 (NTR5599) TRIAL REGISTRATION DATE: 18 December 2015 DATE OF FIRST PATIENT’S ENROLMENT: 26 January 2017…”
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“…RESULTS: A total of 133 term neonates with complex CHD were prospectively enrolled and 110 had analyzable DTI. Multiple patient-specific factors including d-transposition of the great arteries (d-TGA) physiology and severity of impairment of fetal cerebral substrate delivery (i.e., how much the CHD lesion alters typical fetal circulation such that the highest oxygen and nutrient rich blood from the placenta are not directed toward the fetal brain) were predictive of preoperative reduced cost (p < 0.0073) and reduced global/nodal efficiency (p < 0.03). …”
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“…Here, we report long-term safety and efficacy results of the first clinical study of luspatercept in β-thalassemia, initiated in 2013, enrolling adults with both nontransfusion-dependent (NTD) and transfusion-dependent (TD) β-thalassemia. …”
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“…Consistent with VOC circulation during enrollment, the Delta variant was detected in 88.2% (674/764) of participants. …”
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“…FINDINGS: Between April 23, 2014, and Aug 7, 2015, we prescreened 783 children, of whom 407 were enrolled into the study: 135 were randomly assigned to the control group, 136 to the 12 mg screen-and-treat group, and 136 to the 6 mg screen-and-treat group. 345 (85%) children were included in the per-protocol population: 115 in the control group, 116 in the 12 mg screen-and-treat group, and 114 in the 6 mg screen-and-treat group. …”
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“…METHODS: In this retrospective study, a total of 90 neonates diagnosed with HIE who were admitted to our hospital from January 2018 to June 2021 were retrospectively enrolled, and 40 healthy full-term neonates born in our hospital during the same period were randomly selected. …”
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“…METHODS: The study population included older adults previously diagnosed with MDD and a cohort of never-depressed older adults, both of whom have been enrolled in the N-BOLD study at the University of Connecticut Health Center. …”
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“…The aim of the current analysis was to assess the efficacy of nirsevimab using a weight-banded dosing regimen in infants born between 29 weeks gestational age and full term. METHODS: Infants enrolled in the phase 2b and MELODY trials were randomised (2:1) to receive a single intramuscular injection of nirsevimab (infants weighing <5 kg received 50 mg; those weighing ≥5 kg received 100 mg) or placebo before the RSV season. …”
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“…METHOD: Incident cases of IBD diagnosed ≤17y residing in Ontario and enrolled in the Canadian Children IBD Network (CIDsCaNN) between Dec 31 2013 and Jan 31 2019 were linked deterministically using health card number to health administrative data. …”
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“…RESULTS: Twenty-one participants were enrolled in the study: residents (n=15) and attending (n=6) from OTL and EM departments. …”
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“…METHODS: Between 2012 and 2020, patients who underwent posterior medial meniscus root repair at a tertiary referral academic center by fellowship trained sports medicine surgeons were retrospectively identified, recruited, and enrolled in the study. Institutional review board approval and informed consent was obtained. …”
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“…METHODS: Ten subjects [age: 52.9 years (range, 42 – 68 years); 9 female; BMI: 23.2 ± 1.9 kg/m(2); Kellgren- Lawrence (KL): Grade 1, n = 1; Grade 2, n = 9] with symptomatic unilateral knee osteoarthritis were enrolled. Two patients were lost to follow-up at 12-months. …”
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“…Results One hundred forty-six patients enrolled in the run-in phase; 116 patients completed, 94 OOC responders, 92 randomized to RCT phase. …”
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“…Methods: The CLEAR Outcomes trial enrolled 13,970 pts with or at high risk for CV disease, 46% of whom had diabetes and 42% pre-diabetes, and with a baseline mean LDL-C of 3.60 mmol/L. …”
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“…RESULTS: Of 72 participants enrolled (36 in each cohort), 25% were female, 38% were Black, median age was 52 years, 64% had CD4 <200 cells/µL, and 46% had HIV-1 resistant to all 4 major classes (NRTI, NNRTI, PI, INSTI). …”
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“…METHODS: Patients prospectively enrolled in CRACKLE-2 from 56 hospitals in 10 countries between April 30, 2016 to November 30, 2019 with a qualifying CRE bloodstream culture were eligible. …”
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“…RESULTS: A total of 70 healthy Chinese subjects were enrolled in the study. Mean (SD) age was 29.0 (6.32) and 55.7% were male. …”
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“…PARTICIPANTS AND SETTING: Eight hundred two couples treated with ICSI in 10 private and hospital-based IVF programs were enrolled in this study. Of the 484 patients stratified to the I-HB > 65% arm, 115 participants were randomized to the control group, 122 participants were randomized to the HYAL group and 247 participants were randomized to the NP group. …”
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“…MAIN RESULTS: We included 30 RCTs enrolling 8165 participants in this review. Twenty‐four trials were conducted in children in sub‐Saharan Africa, and 21 trials were over 20 years old. …”
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