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301“…Herein, acrosome-reacted (ARed) sperms were rarely detected on the zona pellucida, and spontaneous ARed sperm in eCs -deficient (KO) sperm remained at low levels even with induced capacitation. …”
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302“…A 1-month-old girl child, who was found to have hydrocephalus on prenatal ultrasound, was postnatally evaluated with magnetic resonance imaging (MRI) of brain, which showed two classical findings of septo-optic dysplasia (SOD), namely optic nerve hypoplasia and absent septum pellucidum. In addition, the patient was found to have cerebellar hemiagenesis.…”
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303“…This study demonstrates that capacitation triggers S-nitrosylation and S-glutathionylation (and reverse reactions) of zona-pellucida binding proteins, which may be a new important mechanism that determines the interaction between sperms and oocytes. …”
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304por Maside, Carolina, Sánchez-Ajofrín, Irene, Medina-Chávez, Daniela, Alves, Benner, Garde, José Julián, Soler, Ana Josefa“…In experiment 1, individually matured oocytes were measured and classified into small, intermediate, and large oocytes after a cluster analysis, based on total diameter (with zona pellucida, ZP), oocyte diameter (without ZP), and ZP thickness. …”
Publicado 2021
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305“…The noninvasive approach mainly applied to determine oocyte and embryo competence has been, since the early days of IVF, the morphological evaluation of the mature cumulus-oocyte complex at the time of pickup, first polar body, zona pellucida thickness, perivitelline space and cytoplasm appearance. …”
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306“…The graft is excised and transplanted to the host area pellucida margin. The host is cultured for 18-22 hrs. …”
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307por Ma, Fang, Wu, Diana, Deng, Liwen, Secrest, Patrick, Zhao, June, Varki, Nissi, Lindheim, Steven, Gagneux, Pascal“…Inhibiting sialidase activity interferes with sperm binding to the zona pellucida of the ovum. A survey of human sperm samples for the presence of sialidases NEU1 and NEU3 identified a lack of one or both sialidases in sperm of some male idiopathic infertility cases. …”
Publicado 2012
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308“…We found that the CSE group manifested a reduced diameter of zona pellucida-free oocyte (ZP-free OD) and a morphologically misshapen first polar body (PB). …”
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309por Dai, Xiaoxin, Zhang, Mianqun, Lu, Yajuan, Miao, Yilong, Zhou, Changyin, Sun, Shaochen, Xiong, Bo“…To further figure out the cause, we analyzed ovastacin localization and protein level, the sperm binding ability of zona pellucida, and ZP2 cleavage status in unfertilized eggs from melamine fed mice, and no obvious differences were found between control and treatment groups. …”
Publicado 2015
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310por Ding, Qiao, Wang, Yuxiao, Li, Na, Zhu, Kexue, Hu, Jielun, Wang, Sunan, Zhu, Fan, Nie, Shaoping“…Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. …”
Publicado 2016
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311por Saito, Takako, Bokhove, Marcel, Croci, Romina, Zamora-Caballero, Sara, Han, Ling, Letarte, Michelle, de Sanctis, Daniele, Jovine, Luca“…The structure of the C-terminal zona pellucida module suggests how two copies of ENG embrace homodimeric BMP9, whose binding is compatible with ligand recognition by type I but not type II receptors. …”
Publicado 2017
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312por Mizuno, Naoaki, Mizutani, Eiji, Sato, Hideyuki, Kasai, Mariko, Ogawa, Aki, Suchy, Fabian, Yamaguchi, Tomoyuki, Nakauchi, Hiromitsu“…In this study, we successfully delivered the knockin donor DNA into zygotes by adeno-associated virus (AAV) without removing the zona pellucida, and we succeeded in both large-DNA fragment knockin and whole exon exchange with electroporation of CRISPR/Cas9 ribonucleoprotein. …”
Publicado 2018
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313por Bagheri, Hooman, Friedman, Hana, Shao, Harry, Chong, Yumaine, Lo, Chiu-An, Emran, Farida, Kays, Ibrahim, Yang, Xiang-Jiao, Cooper, Ellis, Chen, Brian E., Siminovitch, Katherine, Peterson, Alan“…Here, we overcome this limitation by first injecting all CRISPR components, including long plasmid-sized DNA templates, into the sub-zona pellucida space. There they are retained, supporting subsequent electroporation. …”
Publicado 2018
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314por Fujiwara, Hiroshi, Ono, Masanori, Sato, Yukiyasu, Imakawa, Kazuhiko, Iizuka, Takashi, Kagami, Kyosuke, Fujiwara, Tomoko, Horie, Akihito, Tani, Hirohiko, Hattori, Akira, Daikoku, Takiko, Araki, Yoshihiko“…Additional clarification of the immune control mechanisms by embryonic signals, such as human chorionic gonadotropin, pre-implantation factor, zona pellucida degradation products, and laeverin, will aid in the further development of immunotherapy to minimize implantation failure in the future.…”
Publicado 2020
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315“…In this review, we first introduce the mammalian egg coat, the zona pellucida (ZP), and summarize what is currently known about its composition, structure, and biological functions. …”
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316por Ichikawa, Yoshinobu, Matsuzaki, Mei, Hiyama, Gen, Mizushima, Shusei, Sasanami, Tomohiro“…We explain that the zona pellucida proteins (ZP1 and ZP3) in the perivitelline membrane play important roles in sperm-egg binding, induction of the acrosome reaction as well as sperm penetration by digestion of sperm protease. …”
Publicado 2016
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317por Körschgen, Hagen, Jäger, Christian, Tan, Kathrin, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel“…Upon sperm–egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and eventually provides a definitive block against polyspermy. …”
Publicado 2020
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318“…Here we show that spermatozoa in gene-edited mice lacking a BTBD18 targeted pachytene piRNA cluster on Chr18 have severe sperm head dysmorphology, poor motility, impaired acrosome exocytosis, zona pellucida penetration and are sterile. The mutant phenotype arises from aberrant formation of proacrosomal vesicles, distortion of the trans-Golgi network, and up-regulation of GOLGA2 transcripts and protein associated with acrosome dysgenesis. …”
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319por MASUDA, Yasumitsu, HASEBE, Ryo, KUROMI, Yasushi, KOBAYASHI, Masayoshi, IWAMOTO, Misaki, HISHINUMA, Mitsugu, OHBAYASHI, Tetsuya, NISHIMURA, Ryo“…Twenty-two parameters, including thickness and volumes of the inner cell mass, trophectoderm, and zona pellucida, and volumes of blastocoel and whole embryo, were quantified from 3D images. …”
Publicado 2021
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320“…In mammals, fertilization involves multiple ordered steps, including the acrosome reaction, zona pellucida penetration, sperm–egg attachment, and membrane fusion. …”
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