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Mostrando 201 - 220 Resultados de 4,819 Para Buscar 'Pirimidina~', tiempo de consulta: 4.65s Limitar resultados
  1. 201
    “…The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chemical models and laboratory experiments have predicted that these compounds can also be produced from chemical precursors found in meteorites. …”
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    Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites
  2. 202
    “…A series of novel dehydroabietic acid derivatives containing pyrimidine moieties were designed and synthesized to explore more efficacious and less toxic antitumor agents according to the principle of combination and hybridization. …”
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    Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
  3. 203
    “…In the present study, a new thiophenyl-pyrimidine derivative was prepared and utilized as an effective antibacterial agent against Gram-positive strains. …”
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    Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative
  4. 204
    “…This study highlights the most potent derivative, N-(4-phenoxy phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine with a MIC(90) value of 0.488 µM and was non-cytotoxic to the Vero cell line. …”
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    Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents
  5. 205
    “…In contrast to N-H perimidine, the N-methylated ligand gave the expected cyclometalated μ-chloro-bridged iridium(III) dimer which was readily converted to a cationic heteroleptic complex with 4,4′-dicarboxy-2,2′-bipyridine. …”
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    A Panchromatic Cyclometalated Iridium Dye Based on 2-Thienyl-Perimidine
  6. 206
    “…[Image: see text] Herein, we report a metal-free one-pot three-component reaction of aryl methyl ketones, 2-aminopyridines, and barbituric acids for the synthesis of pyrimidine-linked imidazopyridines using a catalytic amount of molecular iodine in DMSO medium. …”
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    Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines
  7. 207
    “…The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate‐limiting steps in de novo pyrimidine biosynthesis, a pathway that provides essential metabolic precursors for nucleic acids, glycoproteins, and phospholipids. …”
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    Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia
  8. 208
    “…A variety of structurally different pyrimidines were synthesized. Elemental analysis, FT-IR, (1)H NMR, and (13)C NMR spectroscopy were used to confirm the chemical structures of all prepared compounds. …”
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    Pyrimidines-Based Heterocyclic Compounds: Synthesis, Cytoxicity Evaluation and Molecular Docking
  9. 209
    “…Our work marks the expansion of CRDD technology to both purine and pyrimidine scaffolds.…”
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    Expanding Catch and Release DNA Decoy (CRDD) Technology with Pyrimidine Mimics
  10. 210
    “…This new method enables the hitherto unreported synthesis of functionalized imidazo- and pyrazolo[1,5-a]pyrimidines.…”
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    Unusual rearrangement of imidazo[1,5-a]imidazoles and imidazo[1,2-b]pyrazoles into imidazo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines
  11. 211
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    Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors
  12. 212
    “…Bis[2-(4,6-dimethyl­pyrimidin-2-ylsulfan­yl)eth­yl]amine under hydro­thermal conditions has unexpectedly been transformed into the title compound, C(32)H(44)N(10)S(4). …”
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    Bis[2-((4,6-dimethyl­pyrimidin-2-yl){2-[(4,6-dimethyl­pyrimidin-2-yl)sulfan­yl]eth­yl}amino)­eth­yl] disulfide
  13. 213
    “…We designed and synthesized 33 novel pyrimidine derivatives containing sulfonate groups and evaluated their antibacterial and insecticidal activities. …”
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    Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
  14. 214
    “…Photochemical dimerization of adjacent pyrimidines is fundamental to the creation of mutagenic hotspots caused by ultraviolet light. …”
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    Dynamic accumulation of cyclobutane pyrimidine dimers and its response to changes in DNA conformation
  15. 215
    “…The most prevalent UV-induced DNA lesion is the cyclobutane pyrimidine dimer (CPD), which can cause skin disorders and cancers in humans. …”
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    Mapping the recognition pathway of cyclobutane pyrimidine dimer in DNA by Rad4/XPC
  16. 216
    “…In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination. …”
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    Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings
  17. 217
    “…Some previous evidence suggests that poly-purine/poly-pyrimidine (poly-pu/py) tracts (PPTs), a class of sequence with distinctive biochemical properties, could be involved in recombination, but no general association of PPTs with meiotic recombination hot spots has previously been reported. …”
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    Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots
  18. 218
    por Cleaver, J E, Killpack, S, Gruenert, D C
    Publicado 1985
    “…The two kinds of damage show considerable structural similarity; both involve cyclobutyl bonds to 5,6 positions of pyrimidines as major products and have various minor products. …”
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    Formation and repair of psoralen-DNA adducts and pyrimidine dimers in human DNA and chromatin.
  19. 219
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    The Action of Some Pyrimidine Derivatives and Related Compounds on Sarcoma Development in Grafted Mice
  20. 220
    “…Thus, we performed a comprehensive detection of terminal oligo-pyrimidine (TOP), which is one of the well-characterized cis-regulatory motifs for translational controls located immediately downstream of the transcriptional start sites of mRNAs. …”
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    Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics
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