“…After five rounds of SELEX, MBNL1 selected pyrimidine-rich RNAs containing YGCY motifs. Insertion of multiple YGCY motifs into a normally MBNL1-independent splicing reporter was sufficient to promote regulation by MBNL1. …”
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“…The title chloro-substituted 2-amino­pyrimidine, C(4)H(3)Cl(2)N(3), is a second monoclinic polymorph of this compound which crystallizes in the space group C2/c. …”
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“…In the title compound, C(14)H(8)Cl(2)N(4)O(2), all atoms of the 6-chloro­pyrimidin-4-yl­oxy group and the C atoms at the para positions of the central benzene ring lie on a crystallographic mirror plane. …”
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“…The crystal of the title compound, C(6)H(9)N(3)·C(7)H(6)O(2), contains tetra­meric hydrogen-bonded units comprising a central pair of 2-amino­pyrimidine mol­ecules linked across a centre of inversion by N—H⋯N hydrogen bonds and two pendant benzoic acid mol­ecules attached through N—H⋯O and O—H⋯N hydrogen bonds. …”
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“…One of them is formed by the inter­action of 2-amino-4,6-dimethyl­pyrimidine (AMPY) with the carboxyl group of anthranilic acid (AA) through N—H⋯O and O—H⋯N hydrogen bonds, whereas the other is formed through the inter­action of two centrosymmetrically related pyrimidines involving N—H⋯N hydrogen bonds. …”
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“…The asymmetric unit of the title compound, C(9)H(10)N(4), consists of two mol­ecules in which the dihedral angles between the planes of the imidazole and pyrimidine rings are 4.8 (1) and 2.1 (1)°.…”
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“…The title compound, C(6)H(5)N(5), is almost planar, the triazole and pyrimidine rings forming a dihedral angle of 2.9 (13)°.…”
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“…In the title compound, C(13)H(12)N(2)O(4), the dihedral angle between the benzene and pyrimidine rings is 55.57 (13)°. The carbonyl group and the two methoxyl groups are approximately coplanar with the benzene ring and pyrimidine ring; the C—C—C—O, C—O—C—N and C—O—C—C torsion angles being −6.1 (5), −4.8 (4) and 179.9 (3)°, respectively. …”
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“…Our results indicate the existence of tight and complex links between pyrimidine metabolism and curli/cellulose production: transcription of the csgDEFG operon responds to pyrimidine nucleotide availability, while cellulose production is triggered by exogenous uracil in the absence of active de novo UMP biosynthesis. …”
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“…In the structure of the title salt C(12)H(11)N(2)S(+)·I(−), the methyl­sulfanyl group of the cation is nearly coplanar with the perimidine rings, as indicated by the C—S—C—N torsion angles of 2.9 (5) and −177.2 (3)°, respectively. …”
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“…In conclusion, the antiviral property of pyrimidine biosynthesis inhibitors is not a direct consequence of pyrimidine deprivation on the virus machinery, but rather involves the induction of cellular immune response.…”
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“…The pyrazolo­[3,4-d]pyrimidine ring system of the title compound, C(12)H(10)N(4)S, is essentially planar [maximum deviation = 0.025 (1) Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42 (6)°]. …”
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“…[Image: see text] Pyrimidine (6-4) pyrimidone photoproduct (6-4PP), a common DNA photolesion formed under solar irradiation, was indicated to hydrolyze under strong basic conditions, breaking the N3–C4 bond at the 5′-thymine. …”
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“…Here we show that ThiC, the thiamin pyrimidine synthase in plants and bacteria, contains a tethered cluster-binding domain at its carboxy terminus that moves in and out of the active site during catalysis. …”
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