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Mostrando 241 - 260 Resultados de 4,819 Para Buscar 'Pirimidina~', tiempo de consulta: 4.59s Limitar resultados
  1. 241
    “…Ultraviolet (UV) radiation causes cellular DNA damage, among which cyclobutane pyrimidine dimers (CPDs) are responsible for a variety of genetic mutations. …”
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    Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics
  2. 242
    “…BACKGROUND: The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. …”
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    Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
  3. 243
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    A metal-mediated base pair that discriminates between the canonical pyrimidine nucleobases
  4. 244
    “…A second metastable form of the title compound, C(12)H(13)N(3) (systematic name: 4,6-dimethyl-N-phenyl­pyrimidin-2-amine), was isolated from an attempted co-crystallization experiment with meso-erythriol in dimethyl sulfoxide (DMSO). …”
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    A metastable polymorphic form of the anti­fungal anilino­pyrimidine active pyrimethanil
  5. 245
    “…BACKGROUND: Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the central core for different necessity of biological active compounds, from this facts, we have designed and synthesized a new class of pyrimidin-2-ol/thiol/amine derivatives and screened for its in vitro antimicrobial activity. …”
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    Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues
  6. 246
    “…BACKGROUND: Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. …”
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    Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
  7. 247
    “…De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. …”
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    Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
  8. 248
    “…pyrE (STM3733) encodes orotate phosphoribosyltransferase (OPRTase; EC 2.4.2.10), the fifth enzyme of the de novo pyrimidine biosynthetic pathway. We identified a ΔpyrE mutant as under selection in screening of a Salmonella mutant library in 4-day old chicks. …”
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    De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks
  9. 249
    “…Among several 35C10 derivatives, only one lacking 4-amino group of pyrimidine showed a similar EC50. 35C10 weakly inhibited murine cytomegalovirus, herpes simplex virus type 1, and varicella-zoster virus. …”
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    Characterization of phenyl pyrimidine derivatives that inhibit cytomegalovirus immediate-early gene expression
  10. 250
    “…In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuran chalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. …”
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    Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents
  11. 251
    “…Similarly, treatment of 2 with 3-amino-2H-1,2,4-triazole yielded 6-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl][1,2,4]-triazolo[1,5-a]pyrimidine (5).…”
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    Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
  12. 252
    “…A series of perimidine derivatives (L(1–5)) were prepared and characterized by IR, (1)H·NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis. …”
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    Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies
  13. 253
    por Bajić, Miroslav, Boykin, David W.
    Publicado 2001
    “…The synthesis of 2,4,6-tris(4-N-isopropylamidinophenyl)pyrimidine from 1,3-di(4-bromophenyl)propen-3-one and 4-bromobenzamidine is reported.…”
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    Synthesis of 2,4,6-Tris(4-N-isopropylamidinophenyl)pyrimidine trihydrochloride
  14. 254
    por Maity, Jyotirmoy, Stromberg, Roger
    Publicado 2013
    “…Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. …”
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    An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
  15. 255
    “…[Image: see text] A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of Aβ(1–42) and Aβ(1–40) in the plasma, brain, and cerebrospinal fluid of mice and rats. …”
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    Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
  16. 256
    “…Here, we provide evidence that housecleaning of pyrimidine nucleotide pool via MazG coordinates metabolic adaptation of Mtb to nongrowing state. …”
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    Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis
  17. 257
    “…CONCLUSION: All results suggest that pyrimidine derivatives, especially 1d and 1a, can be considered as safe and efficient tyrosinase inhibitors.…”
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    Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor
  18. 258
    “…The alcohol was debenzoylated with sodium methoxide in a transesterification step to give the nucleoside analogue. The regioisomeric pyrimidine nucleosides were prepared by Vorbrüggen coupling of the 3-hydroxymethylcyclobutanone triflate with either thymine or uracil followed by stereoselective hydride addition. …”
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    Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
  19. 259
    “…In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. …”
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    Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies
  20. 260
    “…New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alkoxyalkyl esters, amino acid phosphoramidates and/or tyrosine. …”
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    New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity
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