“…Using this assay, we identified three molecules that impair EAV infection in equine cells: the broad-spectrum antiviral and nucleoside analog ribavirin, and two compounds previously described as inhibitors of dihydroorotate dehydrogenase (DHODH), the fourth enzyme of the pyrimidine biosynthesis pathway. These molecules effectively suppressed cytopathic effects associated to EAV infection, and strongly inhibited viral replication and production of infectious particles. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs were synthesized via six-step reactions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This method is equally effective for the synthesis of 3-thiocyanatopyrazolo[1,5-a]pyrimidines, both without substituents and with various donor (acceptor) substituents in the pyrimidine ring.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our work herein describes the design and syntheses of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines, with compound 13, the 4-(2-methoxyphenyl)-6-(pyridine-3-yl)pyrimidin-2-amine demonstrating an IC(50) value of 0.38 μM and a promising off-target ADME-Tox profile in vitro. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Taken together, our study highlights the value of multisubstituted pyrimidines to develop novel anti-biofilm agents.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This work presents the results of research related to the determination of application possibilities of new oligoetherols with 1,3-pyrimidine rings and boron atoms in rigid polyurethane foam production. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, we report that the pyrimidine nucleoside phosphorylase from Thermus thermophilus is active over an exceptionally broad pH (4–10), temperature (up to 100 °C) and cosolvent space (up to 80 % (v/v) nonaqueous medium), and displays tremendous stability under harsh reaction conditions with predicted total turnover numbers of more than 10(6) for various pyrimidine nucleosides. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The influence of pH on the complex formation of phosphoethanolamine and pyrimidine nucleosides (uridine, cytidine and thymidine) with copper(II) ions was studied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we study the sequential generation of hotspot mutations in those genes, and uncover a regulatory role of pyrimidine nucleosides in carbon catabolism. Cytidine binds to the cytidine regulator CytR, modifies the expression of sigma factor 32 (RpoH), and thereby impacts global gene expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We furthermore provide early structure‐activity relationships around a new scaffold having a pyrazolo[1,5‐a]pyrimidine core. The most promising pyrazolo[1,5‐a]pyrimidine congener was further investigated and found to inhibit Plasmodium falciparum mPPase in membranes as well as the growth of P. falciparum in an ex vivo survival assay.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at positions 1 and 3 of the six-membered ring. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interestingly, the disorders of pyrimidine and purine metabolites like the known microbial metabolites thymidine and 2′-deoxyuridine had already occurred in liver fibrosis and continued in cirrhosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Early detection of BRCA will increase the probability of cure. Pyrimidine metabolism (PyM) stands for an essential metabolic pathway related to DNA replication of cancer cells, which may also serve as a diagnostic marker and therapeutic target. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An aerobic coupling of 2-aminopyrimidines or 2-aminopyridines with trans-chalcones to afford aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines is reported. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…From the literature, it shows that pyrimidine is one of the most commonly studied heterocycles for its antiproliferative activity against EGFR inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this issue of EMBO Molecular Medicine, So and colleagues investigate the mechanism of action of AG636, a new potent inhibitor of de novo pyrimidine synthesis, and discovered an unexpected link to AML protein translation essential for LSC function.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso