“…Currently, 22 pyrimidine-containing entities are approved for clinical use as anticancer drugs by the FDA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein divided into different enzymatic domains, each catalyzing one of the initial reactions for de novo biosynthesis of pyrimidine nucleotides: glutaminase‐dependent Carbamoyl phosphate synthetase, Aspartate transcarbamoylase, and Dihydroorotase. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A striking observation of these experiments was a coordinated and massive downregulation of genes involved in pyrimidine metabolism. Using transposon insertion mutants, we demonstrated that deletion of carA, a gene involved in pyrimidine synthesis, led to a significant growth defect and to an increased sensitivity of S. aureus to added H(2)O(2). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A series of pyrimidine were synthesized, characterized and evaluated for their antioxidant properties using the human cyclin-dependent kinase-2 protein model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This complex was further utilized as a fine catalyst for the C–C/C–N coupling reactions of pyrimidin-2-yl sulfonates. Subsequently, the cyclic utilization test indicated the high stability and sustainability of this PGS–APTES–Pd(OAc)(2) catalyst, and no activation was required in the recycling process, providing an applicable and reusable catalyst in organic synthesis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was found that both pyrimidine-polymers were more effective in wrapping the semiconducting SWCNTs than the metallic SWCNTs under the co-action of the pyrimidine and fluorene rings. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistical studies in cultured HCC cells demonstrated that VIP treatment partially restored the expression of arginine anabolic key enzyme argininosuccinate synthase (ASS1), and to some extent, inhibited de novo pyrimidine synthetic pathway by downregulating the activation of CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on the structure of Gamhepathiopine, a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hit, active on the sexual and asexual stages of the parasite and thanked for the introduction of various substituents at position 4 of the thienopyrimidine core by nucleophilic aromatic substitution and pallado-catalyzed coupling reactions, a series of 4-substituted thieno[3,2-d]pyrimidines were identified as displaying in vitro activities against both the erythrocytic stage of P. falciparum and the hepatic stage of P. berghei. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The pyrimidine mol­ecules are linked by pairwise N—H⋯N hydrogen bonds, again generating R (2) (2)(8) loops. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Five 2′-deoxyribonucleoside triphosphates (dNTPs) derived from epigenetic pyrimidines (5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, 5-hydroxymethyluracil, and 5-formyluracil) were prepared and systematically studied as substrates for nine DNA polymerases in competition with natural dNTPs by primer extension experiments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, we report a reaction that selectively cleaves the N–N bond of pyrazole and indazole cores to afford pyrimidines and quinazolines, respectively. This chlorodiazirine-mediated reaction provides a unified route to a related pair of heterocycles that are otherwise typically prepared by divergent approaches. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A series of novel pinanyl pyrimidine amine derivatives (1e~1n) and camphoryl pyrimidine amine derivatives (2b~2f) bearing bicyclic monoterpene moieties were designed and synthesized from natural and renewable nopinone and camphor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Unusual rearrangements were shown to accompany Brønsted acid-assisted peri-annulations of 1H-perimidines with 5-alkynylpyrimidines. These transformations take different routes depending on the nature of acetylene precursor, and lead to the formation of 7-formyl-1,3-diazopyrenes.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Minidumbbell (MDB) is a relatively new type of non-B DNA structure formed by pyrimidine-rich STRs. An MDB is composed of two tetraloops or pentaloops, exhibiting a highly compact conformation with extensive loop-loop interactions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the title compound, C(5)H(8)N(3)O(+)·ClO(4) (−)·C(5)H(7)N(3)O·H(2)O, each perchlorate anion is paired with a protonated cationic 2-amino-6-methyl­pyrimidin-4(1H)-one and another non-protonated entity of the same organic pyrimidinone. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A straightforward method for the synthesis of 5-substituted tetrazolo[1,5-a]pyrido[2,3-e]pyrimidines from 2,4-diazidopyrido[3,2-d]pyrimidine in SnAr reactions with N-, O-, and S- nucleophiles has been developed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We previously identified, via scaffold hopping, a pyrido[3,4-d]pyrimidine analogue as a promising CXCR2 antagonist with an IC(50) value of 0.11 µM in a kinetic fluorescence-based calcium mobilization assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this research study, the authors successfully synthesized potent new anticancer agents derived from indazol-pyrimidine. All the prepared compounds were tested for in vitro cell line inhibitory activity against three different cancerous cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso