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Mostrando 41 - 60 Resultados de 4,819 Para Buscar 'Pirimidina~', tiempo de consulta: 4.33s Limitar resultados
  1. 41
    “…[Image: see text] In this paper we describe the optimization of a phenotypic hit against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold. This led to compounds with good pharmacokinetics and oral activity in a P. berghei mouse model of malaria. …”
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    Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
  2. 42
    “…We report the preparation and characterization of three pyrimidine-based monomers, specifically: 1-(2-diallylaminoethyl)uracil, 1-(2-diallylaminoethyl)thymine and 1-(2-diallylaminoethyl)cytosine. …”
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    Synthesis and polymerization of 1-(2-diallylaminoethyl)pyrimidines
  3. 43
    “…The synthesis of steroidal heterocycles containing the pyrazole and pyrimidine ring fused to the 16,17-position of the steroid nucleus is reported. …”
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    Synthesis of New Pyrazole and Pyrimidine Steroidal Derivatives
  4. 44
    “…Then, we report altered mRNA levels for genes from both de novo pyrimidine biosynthesis and pyrimidine salvage pathways in brain from patients with Alzheimer disease. …”
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    Brain pyrimidine nucleotide synthesis and Alzheimer disease
  5. 45
    “…A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. …”
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    Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
  6. 46
    por Mollick, Tanzina, Laín, Sonia
    Publicado 2020
    “…By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation. …”
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    Modulating pyrimidine ribonucleotide levels for the treatment of cancer
  7. 47
    por Gmeiner, William H.
    Publicado 2020
    “…We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year. …”
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    Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine
  8. 48
    “…This gives hope for new drugs for AD, summarized here in with the pyrimidine based natural product inspired molecule as a lead. …”
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    Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease
  9. 49
    por Holt, Rachael A., Seybold, Paul G.
    Publicado 2022
    “…Pyrimidines are key components in the genetic code of living organisms and the pyrimidine scaffold is also found in many bioactive and medicinal compounds. …”
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    Computational Estimation of the Acidities of Pyrimidines and Related Compounds †
  10. 50
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    Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors
  11. 51
    “…Life may not have invented pyrimidine nucleobase biosynthesis from scratch, but simply refined existing nonenzymatic reaction channels. …”
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    A Nonenzymatic Analog of Pyrimidine Nucleobase Biosynthesis
  12. 52
    “…We evaluated the anti-mycobacterial effect of a flavonoid 5,7-dihydroxy-2-(4-hydroxyphenyl) 4H-chromen-4-one (1) and two pyrimidines, 4-hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine (2) and 2-chloro-5-n-nonylpyrimidine (3) in vitro against Mycobacterium tuberculosis (M. tuberculosis, H37Ra) and Mycobacterium avium (M. avium), using a Microplate Alamar Blue Assay (MABA). …”
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    Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds
  13. 53
    “…Rice dihydroorotate dehydrogenase (DHODH), an enzyme of pyrimidine biosynthesis often confused with DHPD, was also characterized. …”
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    New Insights into rice pyrimidine catabolic enzymes
  14. 54
    “…Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. …”
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    Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers
  15. 55
    “…The Cu(I) ion is coordinated in a distorted tetra­hedral geometry by two bridging Br atoms in addition to an N and an S atom from the 2-[(4,6-dimethyl­pyrimidin-2-yl)disulfan­yl]-4,6-dimethyl­pyrimidine ligand. …”
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    Di-μ-bromido-bis­({2-[(4,6-dimethyl­pyrimidin-2-yl)disulfan­yl]-4,6-dimethyl­pyrimidine-κ(2) N (1),S (2)}copper(I))
  16. 56
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    The Effects of Injection of Purine and Pyrimidine Compounds on Grafted Mice
  17. 57
    por Cooper, E. H., Milton, J. D.
    Publicado 1964
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    The Incorporation and Degradation of Pyrimidine DNA Precursors by Human Leucocytes
  18. 58
    “…The distribution of purines and pyrimidines in desoxypentose nucleic acids prepared from a variety of animal and plant sources has been studied. 1. …”
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    PURINE AND PYRIMIDINE CONTENTS OF SOME DESOXYPENTOSE NUCLEIC ACIDS
  19. 59
    “…A proposed function of this pathway, in addition to the maintenance of pyrimidine homeostasis, is the recycling of pyrimidine nitrogen to general nitrogen metabolism. …”
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    A functional analysis of the pyrimidine catabolic pathway in Arabidopsis
  20. 60
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    5-Phenyl-2-(4-pyrid­yl)pyrimidine
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