“…In the title compound, [Sn(CH(3))(3)(C(7)H(7)N(2)O(2)S)(H(2)O)], the Sn(IV) atom has a distorted trigonal–bipyramidal coordination geometry, with one carboxyl­ate O atom of the 2-(4-methyl­pyrimidine-2-sulfan­yl)acetate ligand and the O atom of a water mol­ecule in axial positions, and three methyl groups in equatorial positions. …”
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“…In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7–12) as well as fused pyrazolo[3′,4′:4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14–16) and 7,8,9,10-tetrahydropyrazolo[3′,4′:4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (17) ring systems were synthesized using the starting compound 5-amino-6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (5). …”
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“…The mol­ecule is twisted about the C(p)—S (p = pyrimidine) bond, with a C—S—C—N torsion angle of −19.57 (16)°. …”
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“…In the title compound, C(22)H(21)N(3)O(2), the pyrimidine ring is essentially planar [maximum deviation = 0.018 (2) Å] and forms dihedral angles of 22.70 (8) and 0.97 (7)°, respectively, with the fused benzene ring and the hy­droxy-substituted benzene ring. …”
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“…Irradiation of G-quadruplex forming human telomeric DNA with ultraviolet B (UVB) light results in the formation of anti cyclobutane pyrimidine dimers (CPDs) between loop 1 and loop 3 in the presence of potassium ions but not sodium ions. …”
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“…The isopropyl group is almost perpendicular to the pyrimidine ring with torsion angles of −70.8 (3) and 56.0 (3)°. …”
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“…In the title compound, C(24)H(22)Br(2)N(2)S, the dihedral angles between the central pyrimidine ring and the pendant bromo­benzene rings are 11.02 (11) and 13.20 (12)°. …”
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“…The dihedral angle between the phenyl rings is 68.05 (6)°. The pyrimidine ring is in a flattened boat conformation. …”
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“…In mol­ecule A, the dihedral angles between the partly hydrogenated pyrimidine ring system (r.m.s. deviation = 0.056 Å) and the sp (2)- and sp (3)-bonded phenyl groups are 33.32 (11) and 86.53 (11)°, respectively. …”
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“…Additionally, a study of structure-activity relationships of indolylamino or indolyloxy pyrimidine analogues derived from MKP101 demonstrated that selectivity for epidermal growth factor receptor and other angiokinases, especially vascular endothelial growth factor receptor 2 depends on the position of substituents on pyrimidine and the type of link between pyrimidine and the indole moiety. …”
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“…INTRODUCTION: As pyrimidine is a basic nucleus in DNA and RNA, it has been found to be associated with diverse biological activities. …”
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“…In the title mixed-ligand silver(I) coordination polymeric complex with the non-steroidal anti-inflammatory drug diclofenac (C(14)H(11)Cl(2)NO(2)) (diclH) and pyrimidine (pym), namely poly[{μ(2)-2-[2-(2,6-di­chloro­anilino)phen­yl]acetato-κ(2) O:O′}(μ(2)-pyrimidine-κ(2) N (1):N (3))silver(I)], [Ag(C(14)H(10)Cl(2)NO(2))(C(4)H(4)N(2))](n) or [Ag(μ-dicl)(μ-pym)](n), the very distorted tetra­hedral AgN(2)O(2) coordination centres comprise two N-atom donors from bridging pym ligands [Ag—N = 2.381 (3) and 2.412 (3) Å] and two carboxyl­ate O-atom donors from dicl ligands [Ag—O = 2.279 (2) and 2.280 (2) Å], which bridge Ag atoms, giving a centrosymmetric dinuclear units with a short Ag⋯Ag separation [2.8931 (5) Å]. …”
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“…The aim of this study was to evaluate the effects of 4c pyrazolo[3,4-d]pyrimidine compound, a Src inhibitor, on lymphoid and myeloid neoplasms. …”
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“…Here we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway, dihydropyrimidine dehydrogenase (DPYD) and its effect on pharmacokinetics of and response to 5-fluorouracil (5-FU). …”
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“…In the title compound, C(9)H(9)ClN(2)O, the ethynyl­pyrimidine moiety displays an almost planar geometry. …”
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“…Incubation with vitamin E before UVAI exposure decreased the formation of oxidized purines (with a decrease in intracellular oxidizing species), and cyclobutane pyrimidine dimers (CPD). A possible sunscreening effect was excluded when similar results were obtained following vitamin E addition after UVAI exposure. …”
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“…1‐Ethoxymethyl‐5‐fluorouracil (EM‐FU) is a fluorinated pyrimidine derived from 5‐FU, and 3‐cyano‐2,6‐dihydroxypyridine (CNDP) is a chemical modulator which suppresses the catabolism of 5‐FU by inhibiting dihydrouracil dehydrogenase in the liver. …”
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“…In this study, we demonstrated the efficacy of a pyrimidine synthesis inhibitor, N-phosphonacetyl-l-aspartate (PALA), to enhance clearance of methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Acinetobacter baumannii strains by primary human dermal fibroblasts in vitro. …”
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