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81“…BACKGROUND: Nucleotide metabolism is a critical pathway that generates purine and pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics. …”
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82“…A wealth of evidence has demonstrated that dysfunction of pyrimidine metabolism is closely related to cancer progression and numerous drugs targeting pyrimidine metabolism have been approved for multiple types of cancer. …”
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84“…We also highlight newly emerged targets in pyrimidine synthesis as well as pyrimidine salvage as a promising target in immunotherapy.…”
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85por Alqahtani, Saad Saeed, Koltai, Tomas, Ibrahim, Muntaser E., Bashir, Adil H. H., Alhoufie, Sari T. S., Ahmed, Samrein B. M., Molfetta, Daria Di, Carvalho, Tiago M. A., Cardone, Rosa Angela, Reshkin, Stephan Joel, Hifny, Abdelhameed, Ahmed, Mohamed E., Alfarouk, Khalid OmerEnlace del recurso
Publicado 2022
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86por Hinteregger, Clemens, Dolensky, Johanna, Seebacher, Werner, Saf, Robert, Mäser, Pascal, Kaiser, Marcel, Weis, Robert“…A couple of hybrids of 2-azabicyclo-nonanes with 2-(dialkylamino)pyrimidines possessed high activity against Trypanosoma brucei rhodesiense STIB900 and good selectivity.…”
Publicado 2022
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88por Yamuna, Thammarse S., Jasinski, Jerry P., Kaur, Manpreet, Anderson, Brian J., Yathirajan, H. S.Enlace del recurso
Publicado 2014
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89por Reddy Kotla, Siva K., Vandavasi, Jaya Kishore, Wang, Jeh-Jeng, Parang, Keykavous, Tiwari, Rakesh K.“…[Image: see text] A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]pyrimidines. The developed protocol provides a practical approach for the synthesis of biologically important substituted pyrimidines from easily available substrates, with a broad substrate scope under mild reaction conditions.…”
Publicado 2017
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90“…Therefore, the present study aims to investigate the chemistry of heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine skeletons and their biological characteristics. …”
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91por Walter, Melanie, Mayr, Florian, Hanna, Bishoy M. F., Cookson, Victoria, Mortusewicz, Oliver, Helleday, Thomas, Herr, Patrick“…The NUDIX hydrolase NUDT22 converts UDP-glucose into glucose-1-phosphate and the pyrimidine nucleotide uridine monophosphate but a biological significance for this biochemical reaction has not yet been established. …”
Publicado 2023
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94por Patil, Sharanabasappa B.“…Pyrimidine derivatives attract researchers due to their versatile scaffold & their medicinal significance. …”
Publicado 2023
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95por Gao, Shangyu, Sun, Yu, Chen, Xiaoguang, Zhu, Changhua, Liu, Xiaoye, Wang, Wenlei, Gan, Lijun, Lu, Yanwu, Schaarschmidt, Frank, Herde, Marco, Witte, Claus-Peter, Chen, Mingjia“…Given the similarities between pyrimidine catabolism in plants, mammals and other eukaryotes, we hypothesize that the removal of 5mU is an important function of pyrimidine degradation in many organisms, which in plants serves to protect RNA from stochastic m(5)U modification.…”
Publicado 2023
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96por Bardot, V., Dutrillaux, A. M., Delattre, J. Y., Vega, F., Poisson, M., Dutrillaux, B., Luccioni, C.“…In parallel, two enzymes involved in pyrimidine metabolism, thymidine kinase and thymidylate synthase (TS), were studied. …”
Publicado 1994
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98“…These chalcones were immediately reacted with urea, thiourea and guanidine hydrochloride in presence of concentrated hydrochloric acid as reagent to obtain the corresponding hydroxy, thio and amino pyrimidines. The synthesized heterocyclics were characterized on the basis of physical, chemical tests and spectroscopic data and were tested for the acute antiinflammatory activity, antioxidant, antibacterial activity using carragenan-induced rat paw oedema method, DPPH (diphenylpicrylhydrazyl) radical scavenging method and cup plate method using Muller-Hinton agar media respectively. …”
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99por Chantrapromma, Suchada, Fun, Hoong-Kun, Jana, Subrata, Hazra, Anita, Goswami, Shyamaprosad“…The dihedral angle between the pyrimidine and benzene rings is 80.78 (6)°. The two pyrimidine rings are parallel by virtue of the centre of symmetry. …”
Publicado 2007
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