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  1. 1001
    por Gao, Shan, Ng, Seik Weng
    Publicado 2010
    “…The water-coordinated Zn atom in the title monoaqua zinc nitrate adduct of 2-amino­pyrimidine, [Zn(NO(3))(2)(C(4)H(5)N(3))(2)(H(2)O)], is bonded to a monodentate nitrate ion and is chelated by the other nitrate ion. …”
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    Bis(2-amino­pyrimidine-κN (1))aqua­(nitrato-κO)(nitrato-κ(2) O,O′)zinc(II)
  2. 1002
    “…The title compound, C(21)H(22)N(2)O(4), was prepared by reaction of 6-methyl­pyrimidine-2,4(1H,3H)-dione and 1-chloro­methyl-4-meth­oxy­benzene. …”
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    1,3-Bis(4-meth­oxy­benz­yl)-6-methyl­pyrimidine-2,4(1H,3H)-dione
  3. 1003
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    tert-Butyl N-[3-hy­droxy-1-phenyl-4-(pyrimidin-2-ylsulfan­yl)butan-2-yl]carbamate monohydrate
  4. 1004
    “…The title compound, C(12)H(14)BrN(3)O, is built up from two fused six-membered rings and one six-membered ring linked through a spiro C atom. The hydro­pyrimidine ring has an envelope conformation and the cyclo­hexane ring is in a chair conformation. …”
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    6′-Bromo-1′H-spiro­[cyclo­hexane-1,2′-pyrido[2,3-d]pyrimidin]-4′(3′H)-one
  5. 1005
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    1-(6-Methyl-3-phenyl-2-sulfanyl­idene-1,2,3,4-tetra­hydro­pyrimidin-5-yl)ethanone
  6. 1006
    “…The title compound, [HgCl(2)(C(4)H(5)N(3))](n), features a two-dimensional network parallel to (001) that is based on an Hg(II) atom octahedrally coordinated by four μ(2)-Cl atoms and two μ(2)-2-amino­pyrimidine (apym) ligands in trans positions, yielding a distorted HgCl(4)N(2) octa­hedron. …”
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    Poly[(μ(2)-2-amino­pyrimidine-κ(2) N (1):N (3))di-μ(2)-chlorido-mercury(II)]
  7. 1007
    “…The title compound, C(12)H(17)N(5)O, was obtained by cyclo­condensation of 2,4-diamino­pyrimidine-5-carbonitrile with cyclo­hepta­none. The tetra­hydro­pyrimidine ring has a dis­torted boat conformation and the cyclo­heptane ring adopts a chair conformation. …”
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    7′-Amino-1′H-spiro­[cyclo­heptane-1,2′-pyrimido[4,5-d]pyrimidin]-4′(3′H)-one
  8. 1008
    “…In the title compound, C(25)H(23)FN(4), the pyrimidine ring makes dihedral angles of 11.3 (2), 24.5 (2) and 70.1 (2)° with the phenyl and two benzene rings, and the mol­ecular conformation is stabilized by an intra­molecular N—H⋯N hydrogen bond with an S(6) ring motif. …”
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    5-[(4-Fluoro­anilino)meth­yl]-6-methyl-N-(4-methyl­phen­yl)-2-phenyl­pyrimidin-4-amine
  9. 1009
    “…In the title polymer, [Cd(C(5)H(3)N(2)O(2))(NO(3))(H(2)O)](n), the Cd(II) atom is seven-coordinate in a distorted capped octa­hedral geometry by two N atoms of two different pyrimidine dicarboxyl­ate (pmc) ligands, three O atoms from three separate pmc ligands, and two O atoms of disordered nitrate anions or water mol­ecules. …”
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    Poly[aqua­(μ(2)-pyrimidine-2-carboxyl­ato-κ(4) O,N:O′,N′)(nitrato-κO)cadmium]
  10. 1010
    “…Recent data suggest that the cyclic pyrimidine nucleotides cytidine 3′,5′-cyclic monophosphate (cCMP) and uridine 3′,5′-cyclic monophosphate (cUMP) also act as second messengers. …”
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    Analysis of Substrate Specificity and Kinetics of Cyclic Nucleotide Phosphodiesterases with N’-Methylanthraniloyl-Substituted Purine and Pyrimidine 3′,5′-Cyclic Nucleotides by Fluorescence Spectrometry
  11. 1011
    por Smith, Graham, Wermuth, Urs D.
    Publicado 2013
    “…In the structure of the phenolate salt of the sulfa drug sulfamethazine with 3,5-dinitro­salicylic acid, C(12)H(15)N(4)O(2)S(+)·C(7)H(3)N(2)O(7) (−), the dihedral angle between the pyrimidine and benzene rings of the cation is 59.70 (17)°. …”
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    2-(4-Amino­benzene­sulfonamido)-4,6-dimethyl­pyrimidin-1-ium 2-carb­oxy-4,6-dinitro­phenolate
  12. 1012
    “…Here, we describe the crystal structure of Pim1 in complex with a newly developed pyrido[4,3-d]pyrimidine-derivative inhibitor (SKI-O-068). Our inhibitor exhibits a half maximum inhibitory concentration (IC(50)) of 123 (±14) nM and has an unusual binding mode in complex with Pim1 kinase. …”
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    Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode
  13. 1013
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    Correction: A Ham1p-Dependent Mechanism and Modulation of the Pyrimidine Biosynthetic Pathway Can Both Confer Resistance to 5-Fluorouracil in Yeast
  14. 1014
    “…The DKO was unable to grow in pyrimidine-depleted medium in vitro, unless supplemented with uracil, uridine, deoxyuridine or UMP. …”
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    Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy
  15. 1015
    por Tang, Caifei, Li, Zhiming, Wang, Quanrui
    Publicado 2013
    “…Oxidative cyclization of 6-chloro-4-pyrimidinylhydrazones 4 with iodobenzene diacetate (IBD) in dichloromethane gives rise to [1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–o. These incipient products undergo feasible Dimroth rearrangement to furnish the isolated [1,2,4]triazolo[1,5-c]pyrimidines 6a–o in moderate to high yields.…”
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    IBD-mediated oxidative cyclization of pyrimidinylhydrazones and concurrent Dimroth rearrangement: Synthesis of [1,2,4]triazolo[1,5-c]pyrimidine derivatives
  16. 1016
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    Detection of Intermediates in the Oxidative Half-Reaction of the FAD-Dependent Thymidylate Synthase from Thermotoga maritima: Carbon Transfer without Covalent Pyrimidine Activation
  17. 1017
    “…Michael addition reaction of the 2-amino-1,3,4-thiadiazole to chalcone as biselectrophile afforded 5,7-diphenyl-6-[1,3-diphenylpropan-1-on-3-yl][1,3,4]thiadiazolo[3,2-a]pyrimidine (3) instead of 5,7-diphenyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidine (5) via further Michael addition at C(5) in pyrimidine moiety. …”
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    Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives
  18. 1018
    “…In the title salt, C(4)H(7)N(4)O(+)·C(7)H(7)O(3)S(−), the 2,6-di­amino-4-oxo-1,3-di­hydro­pyrimidin-1-ium cation inter­acts with the sulfonate group of the p-toluene­sulfonate anion via a pair of N—H⋯O hydrogen bonds, forming a hetero-synthon R (2) (2)(8) that mimics the role of a carboxyl­ate. …”
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    Crystal structure of 2,4-di­amino-6-oxo-3,6-di­hydro­pyrimidin-1-ium p-toluene­sulfonate
  19. 1019
    “…Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts (6-4PP). …”
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    Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes
  20. 1020
    “…New series of spiro indeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. …”
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    Synthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′-Indolines as New Urease Inhibitors
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