“…In the title compound, C(25)H(13)Cl(2)F(4)N(3), there are four planar systems, viz. three benzene rings and a pyrazolo­[1,5-a]pyrim­idine system [r.m.s. deviation = 0.002 Å]. The dihedral angle between the dichloro­phenyl ring and the unsubstituted phenyl ring is 69.95 (5)°, while that between the fluoro­phenyl ring and the unsubstituted phenyl ring is 7.97 (10)°. …”
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“…In the title compound, C(22)H(23)BrN(4)O(4)S(2), the benzene rings bridged by the sulfonamide group are tilted relative to each other by 68.9 (1)° and the dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 69.7 (1)°. The mol­ecular conformation is stabilized by a weak intra­molecular π–π stacking inter­action between the pyrimidine and the 4-methylbenzene rings [centroid–centroid distance = 3.934 (2) Å]. …”
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“…In the title compound, C(21)H(20)BrClN(4)O(4)S(2), the benzene rings bridged by the sulfonamide group are tilted relative to each other by a dihedral angle of 70.2 (1)° and the dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 69.5 (1)°. The mol­ecular conformation is stabilized by a weak intra­molecular π–π stacking inter­action between the pyrimidine and the 4-chloro­benzene rings [centroid–centroid distance = 3.978 (2) Å]. …”
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“…In the title compound, C(23)H(25)BrN(4)O(3)S(2), the benzene rings bridged by the sulfonamide group are tilted relative to each other by 69.7 (1)° and the dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 70.4 (1)°. The mol­ecular conformation is stabilized by a weak intra­molecular π–π stacking inter­action between the pyrimidine and the 4-methyl benzene rings [centroid–centroid distance = 3.633 (2) Å]. …”
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“…In the title compound, C(30)H(23)ClN(6)OS, the benzyl, the 3-chloro­anilino, the phenyl and the anilino groups form dihedral angles of 85.95 (6), 29.63 (7), 28.55 (1) and 87.48 (6)°, respectively, with the pyrazolo­[3,4-d]pyrimidine unit [maximum deviation = 0.052 (2) Å]. An intra­molecular N—H⋯N hydrogen bond occurs. …”
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“…In the title molecular salt, C(19)H(18)BrClN(3)O(2) (+)·Cl(−), the dihedral angles between the pyrimidine ring and the chlorobenzene and bromobenzene rings are 72.4 (2) and 45.5 (2)°, respectively. …”
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“…In the anions, the dihedral angles between the pyrimidine and benzene rings are 42.77 (6) and 46.55 (7)°. …”
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“…The dihedral angles between the pyrimidine ring and the attached phenyl, meth­oxy­phenyl and tri­fluoro­methyl­phenyl rings are 8.1 (2), 37.5 (2) and 70.7 (2)°, respectively, in mol­ecule A, and 9.3 (2), 5.3 (2) and 79.7 (2)° in mol­ecule B. …”
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“…In the title mol­ecule, C(13)H(14)N(2)O(3)S, the di­hydro­pyrimidine ring is in a flattened sofa conformation, with the methine C atom forming the flap. …”
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“…Sunlight-induced C to T mutation hotspots in skin cancers occur primarily at methylated CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation. The C or 5-methyl-C in CPDs are not stable and deaminate to U and T, respectively, which leads to the insertion of A by DNA polymerase η and defines a probable mechanism for the origin of UV-induced C to T mutations. …”
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“…The 4-amino-5-fluoro-2-oxo-2,3-di­hydro­pyrimidine mol­ecule is protonated at one of the pyrimidine N atoms. …”
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“…In the title compound, C(24)H(18)N(2)OS, the pyrimidine ring has a flat envelope conformation with the methine C atom as the flap. …”
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“…ABSTRACT: Knoevenagel condensation of barbituric acids with aromatic aldehydes containing one or two formyl groups was carried out. 5-Arylidenebarbituric acids underwent smooth hetero-Diels-Alder (HDA) reactions with enol ethers to afford cis and trans diastereoisomers of pyrano[2,3-d]pyrimidine-2,4-diones and 5,5′-(1,4-phenylene)bis[2H-pyrano[2,3-d]pyrimidine-2,4(3H)-dione] derivatives in excellent yields (75–88 %). …”
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“…In the title compound, C(13)H(13)FN(2)O(2)S, the pyrimidine ring adopts a twist-boat conformation with the MeCN and methine-C atoms displaced by 0.0938 (6) and 0.2739 (3) Å, respectively, from the mean plane through the other four atoms of the ring. …”
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“…Among the synthesized compounds, the N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives selectively targeted some members of class III receptor tyrosine kinase family. …”
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“…Solvent-free synthesis of pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones by ball-milling and without any catalyst is described. …”
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“…In the title mol­ecule, C(19)H(16)N(4)O, the planar pyrazolo­pyrimidine moiety is inclined to the attached phenyl rings by 35.42 (4) and 54.51 (6)°. …”
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