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121por Zakharenko, Alexandra L., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Ivanov, Georgy A., Oslovsky, Vladimir E., Ilina, Ekaterina S., Chernyshova, Irina A., Lavrik, Olga I., Mikhailov, Sergey N.“…Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. …”
Publicado 2020
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122“…For example, phages carry in their genomes modified pyrimidines such as 5-hydroxymethyl-cytosine (5hmC) in T4gt deficient in α- and β-glycosyltransferases, glucosylated-5-hydroxymethylcytosine (5gmC) in T4, 5-methylcytosine (5mC) in Xp12, and 5-hydroxymethyldeoxyuridine (5hmdU) in SP8. …”
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124“…In this study, 17 novel pyrimidine derivatives containing an amide moiety were synthesized. …”
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125por Mittersteiner, Mateus, Farias, Fellipe F.S., Bonacorso, Helio G., Martins, Marcos A.P., Zanatta, Nilo“…The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic routes that provide shorter reaction times, higher yields, and site-selective reactions are constantly being sought. …”
Publicado 2021
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126por Li, Shen, Yokota, Tomohiro, Wang, Ping, ten Hoeve, Johanna, Ma, Feiyang, Le, Thuc M., Abt, Evan R., Zhou, Yonggang, Wu, Rimao, Nanthavongdouangsy, Maxine, Rodriguez, Abraham, Wang, Yijie, Lin, Yen-Ju, Muranaka, Hayato, Sharpley, Mark, Braddock, Demetrios T., MacRae, Vicky E., Banerjee, Utpal, Chiou, Pei-Yu, Seldin, Marcus, Huang, Dian, Teitell, Michael, Gertsman, Ilya, Jung, Michael, Bensinger, Steven J., Damoiseaux, Robert, Faull, Kym, Pellegrini, Matteo, Lusis, Aldons J., Graeber, Thomas G., Radu, Caius G., Deb, Arjun“…These observations demonstrate that the cardiac muscle cell regulates pyrimidine metabolism in nonmuscle cells by releasing adenine and specific nucleosides after heart injury and provide insight into how intercellular regulation of pyrimidine biosynthesis can be targeted and monitored for augmenting tissue repair.…”
Publicado 2022
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127por Jakubkiene, Virginija, Valiulis, Gabrielius Ernis, Schweipert, Markus, Zubriene, Asta, Matulis, Daumantas, Meyer-Almes, Franz-Josef, Tumkevicius, Sigitas“…Here, the synthesis of new compounds in which a hydroxamic acid residue is attached to differently substituted pyrimidine rings via a methylene group bridge of varying length as potential HDAC inhibitors is described. …”
Publicado 2022
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128por Cavalli, Elfie S., Mies, Thomas, Rzepa, Henry S., White, Andrew J. P., Parsons, Philip J., Barrett, Anthony G.M.“…[Image: see text] An efficient two-step procedure for the syntheses of pyrimidine nucleosides is presented. A series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared from β-anomeric isonitriles by reaction with Meldrum’s acid or by allowing aminomethylene Meldrum’s acid to react with an 1-aldofuranosyl halide or acetate. …”
Publicado 2022
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129por Yang, Hua“…Colourless crystals of the title compound, [Ag(C(5)H(7)N(3))(C(6)H(9)N(3))]NO(3), separated out of a solution of 2-amino-4-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine and silver nitrate in water and methanol. …”
Publicado 2009
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130por Yang, Hua“…Colourless crystals of the title mixed ligand complex, [Ag(C(5)H(7)N(3))(C(6)H(9)N(3))]ClO(4), were obtained from a solution of 2-amino-4-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine and silver perchlorate in water and methanol. …”
Publicado 2009
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131por Kalle, Paulina, Tatarin, Sergei V., Kiseleva, Marina A., Zakharov, Alexander Yu., Smirnov, Daniil E., Bezzubov, Stanislav I.“…The title compounds, 2-(4-methylphenyl)-1H-perimidine hemihydrate (1, C(18)H(14)N(2)·0.5H(2)O) and 1-methyl-2-(4-methylphenyl)-1H-perimidine (2, C(19)H(16)N(2)), were prepared and characterized by (1)H NMR and single-crystal X-ray diffraction. …”
Publicado 2022
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132“…Syntheses of several novel 4-chloropyrrolo[2,3-d]pyrimidines (1), 4- hydrazinopyrrolo[2,3-d]pyrimidines (2) and 3-amino-4-iminopyrrolo[2,3-d]pyrimidines (7) and their use in the synthesis of tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (3) and triazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (4) required for biological screening are reported.…”
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134“…In the crystal structure of the title compound, [Fe(3)(NCS)(6)(C(4)H(4)N(2))(8)](n), each iron(II) cation is coordinated by four N-bonded pyrimidine ligands and two N-bonded thiocyanate anions in a distorted octahedral environment. …”
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135“…Compound 5 reacts with acetophenone and 2-acetylthiophene to give the 2-thioxo-1,3-dihydropyridino[2,3-d]pyrimidin-4-ones 3a and 3b, respectively. Compounds 3a,b react with hydrazonoyl halides 6,7 to give pyridino[2,3-d]triazolo[4,5-a]pyrimidin-4-ones 11a-d and not the isomeric structures 12a-d. …”
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136por Dashteh, Mohammad, Makhdoomi, Sajjad, Baghery, Saeed, Zolfigol, Mohammad Ali, Khazaei, Ardeshir, Gu, Yanlong“…Then, [(VO)TPP][(TCM)(4)] was used as a benign and expedient catalyst for the synthesis of numerous heterocyclic compounds such as 5-amino-7-(aryl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles, 5-amino-7-(aryl)-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles, 7-(aryl)-7,12-dihydro-5H-isochromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-5-ones, and 4-(aryl)-2-(1H-indol-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitriles under solvent-free conditions at 100 °C via a cooperative geminal-vinylogous anomeric based oxidation.…”
Publicado 2022
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137por Akberdin, Ilya R., Kozlov, Konstantin N., Kazantsev, Fedor V., Fadeev, Stanislav I., Likhoshvai, Vitaly A., Khlebodarova, Tamara M.“…Earlier studies aimed at investigating the metabolism of endogenous nucleoside triphosphates in synchronous cultures of E. coli cells revealed an auto-oscillatory mode of functioning of the pyrimidine and purine nucleotide biosynthesis system, which the authors associated with the dynamics of cell division. …”
Publicado 2023
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138por Lozano‐Terol, Gema, Gallego‐Jara, Julia, Sola‐Martínez, Rosa Alba, Ortega, Álvaro, Martínez Vivancos, Adrián, Cánovas Díaz, Manuel, de Diego Puente, Teresa“…The de novo pyrimidine biosynthesis pathway is an important route due to the relevance of its products, its implications in health and its conservation among organisms. …”
Publicado 2022
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139“…A series of 4-(3,4-dichloroisothiazol-5-yl)-7-(2-((5-(5-pyrimidin-4-yl)amino)ethoxy)-8-methyl) coumarin derivatives were designed and synthesized by Williamson ether condensation and substitution reactions. …”
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