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  1. 13281
    “…Here we investigated the tumor-promoting effects of ADCY3 overexpression and confirmed a significant correlation between the upregulation of ADCY3 and Lauren's intestinal-type gastric cancers. ADCY3 overexpression increased cell migration, invasion, proliferation, and clonogenicity in HEK293 cells; conversely, silencing ADCY3 expression in SNU-216 cells reduced these phenotypes. …”
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    Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway
  2. 13282
    “…Survival analysis demonstrated that high expression of LDH-A in GC was associated with lower overall survival (OS). When stratified by Lauren grade and histological classification, significance appeared in diffuse type and undifferentiated type GC. …”
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    Clinicopathological Significance and Prognostic Value of Lactate Dehydrogenase A Expression in Gastric Cancer Patients
  3. 13283
    “…Generalized estimating equation and Rogen-Gladen estimator models were used to calculate apparent and true prevalences of different trypanosomes while intra cluster correlations were estimated using a 1-way mixed effect analysis of variance (ANOVA) in R statistical software version 3.0.2. …”
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    The burden and spatial distribution of bovine African trypanosomes in small holder crop-livestock production systems in Tororo District, south-eastern Uganda
  4. 13284
    “…Clinicopathological factors such as age, Lauren classification, sex, tumor infiltration, lymph node metastasis, and histologic grade did not show a statistically significant association with the methylation status of the IGFBP-3 promoter. …”
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    Clinical Significance of IGFBP-3 Methylation in Patients with Early Stage Gastric Cancer()
  5. 13285
    “…Univariate analysis revealed that depth of invasion, lymph node metastasis, tumor node metastasis (TNM) stage, Lauren classification, and MAGE and CEA expressions were independent prognostic factors for recurrence. …”
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    Prognostic Value of Genetic Detection Using CEA and MAGE in Peritoneal Washes With Gastric Carcinoma After Curative Resection: Result of a 3-Year Follow-Up
  6. 13286
    “…There was an association between HER2 expression and Laurén’s intestinal histological subtype (P = 0.048), well to moderately differentiated tumors (P = 0.004) and presence of lymphovascular invasion (P = 0.031). …”
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    Association between HER2 status in gastric cancer and clinicopathological features: a retrospective study using whole-tissue sections
  7. 13287
    “…It is proposed that records of Pheidole moerens Forel outside of the Mesoamerica and the Caribbean refer instead to Pheidole navigans or other heterospecific taxa in the Pheidole flavens species complex. We propose that the names Pheidole anastasii Emery and Pheidole floridana Emery have been widely misapplied to North American outdoor records of Pheidole bilimeki Mayr. …”
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    Introduced Pheidole of the world: taxonomy, biology and distribution
  8. 13288
    “…RESULTS: The results show that the expression level of miR-34a was decreased in human gastric cancer cell lines and tissues, and down-regulated expression of miR-34a was associated with Lauren classification (P = 0.034). Decreased miR-34a expression in gastric cancer tissues was positively correlated with poor OS of gastric cancer patients (P = 0.013). …”
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    Prognostic Significance of MiR-34a Expression in Patients with Gastric Cancer after Radical Gastrectomy
  9. 13289
    “…There was no statistically significant difference in age, sex, tumor location, differentiation, Lauren classification, TNM staging, presence of distant metastasis, depth of tumor invasion (T), lymphovascular invasion, and survival between c-Met subgroups. …”
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    Evaluation of c-Met, HGF, and HER-2 expressions in gastric carcinoma and their association with other clinicopathological factors
  10. 13290
    “…The present study revealed that the expression level of Musashi-1 protein in gastric cancer was significantly upregulated and correlated with the tumor size, tumor-node-metastasis (TNM) stage, Lauren classification, depth of invasion, vessel invasion, lymph node metastasis and distant metastasis. …”
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    Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer
  11. 13291
    “…Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse). RESULTS: Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. …”
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    Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study
  12. 13292
    “…Current classification systems, including the WHO, Lauren, and TCGA, have clarified the pathological and molecular profiles of GC. …”
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    Immunoclassification characterized by CD8 and PD-L1 expression is associated with the clinical outcome of gastric cancer patients
  13. 13293
    “…Tumors were classified according to the Lauren criteria as diffuse or intestinal types. RESULTS: The median age of the patients was 59.0 years, and 33.8% were female. …”
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    Characteristics of non-cardia gastric cancer with a high serum anti-Helicobacter pylori IgG titer and its association with diffuse-type histology
  14. 13294
    “…About 90% of ERBB2+ GC was compatible with chromosome instability (CIN) subtype of TCGA, which overlaps with intestinal-type GC in Lauren classification. In validating experiments, combination of Lapatinib and all-trans retinoic acid (ATRA) synergistically suppresses cell growth, and accompanied by decreased expression of MYC. …”
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    Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer
  15. 13295
    “…Lauren classification is a pathology-based gastric cancer (GC) subtyping system, which is widely used in the clinical treatment of patients with GC. …”
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    Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer
  16. 13296
    “…All reported HDGCs are the pure diffuse type by Lauren classification and are associated with dismal prognosis once the tumor invades the submucosa. …”
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    CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment
  17. 13297
    “…There is evidence that: (1) the ADC is a promising biomarker for the evaluation of the aggressiveness (T and N stage), treatment response and prognosis of gastric cancer; (2) textural features are related to the degree of differentiation, Lauren classification, treatment response and prognosis of gastric cancer. …”
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    Gastric cancer and imaging biomarkers: Part 1 – a critical review of DW-MRI and CE-MDCT findings
  18. 13298
    por Ahmed, Ayesha
    Publicado 2019
    “…Clinico-pathological parameters, Laurens histological classification, and immunohistochemical staining for Her3, p53, and Ki-67 were done. …”
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    Prevalence of Her3 in gastric cancer and its association with molecular prognostic markers: a Saudi cohort based study
  19. 13299
    “…Intestinal-type gastric cancer (GC) of the Lauren classification system has specific epidemiological characteristics and carcinogenesis patterns. …”
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    MicroRNA-1224 Inhibits Tumor Metastasis in Intestinal-Type Gastric Cancer by Directly Targeting FAK
  20. 13300
    “…We found no correlation with survival, Laurén phenotype, or any other clinico-pathological patient characteristic. …”
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    Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
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