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Mostrando 441 - 460 Resultados de 31,836 Para Buscar 'Pnau~', tiempo de consulta: 3.95s Limitar resultados
  1. 441
    “…Herein we report a PNA·DNA strand displacement-activated fluorescent probe that can image the expression of iNOS (inducible nitric oxide synthase) mRNA, a marker of inflammation. …”
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    Imaging mRNA Expression in Live Cells via PNA·DNA Strand Displacement-Activated Probes
  2. 442
    “…They are highly stable and efficiently and selectively interact with RNA. However, some properties of non-modified aminoethyl glycine PNAs (aegPNA) hamper their in vivo applications. …”
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    Side chain modified peptide nucleic acids (PNA) for knock-down of six3 in medaka embryos
  3. 443
    “…The enhanced thermodynamic stability of PNA:DNA and PNA:RNA duplexes compared with DNA:DNA and DNA:RNA duplexes has been attributed in part to the lack of electrostatic repulsion between the uncharged PNA backbone and negatively charged DNA or RNA backbone. …”
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    Evaluating the Effect of Ionic Strength on Duplex Stability for PNA Having Negatively or Positively Charged Side Chains
  4. 444
    “…One of the isolates, NAU‐1 (aerobic, Gram‐positive, non‐motile, coccobacilli), was hyper‐tolerant to arsenite (As(III), 23 mM) and arsenate (As(V), 180 mM). 16S rRNA gene of NAU‐1 was 99% similar to the 16S rRNA genes of Rhodococcus (Accession No. …”
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    Remodulation of central carbon metabolic pathway in response to arsenite exposure in Rhodococcus sp. strain NAU‐1
  5. 445
    “…The methodology was applied to create two libraries of cell-penetrating peptide (CPP)–PNA705 conjugates from parallel-synthesized peptide libraries. …”
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    Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo
  6. 446
    “…After assembly of the PNA-DNA construct a padlock probe is circularized on the free strand. …”
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    Visual Detection of Bacterial Pathogens via PNA-Based Padlock Probe Assembly and Isothermal Amplification of DNAzymes
  7. 447
    “…Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation occurs with similar rates and substrate specificities as in experiments with DNA conjugates we performed earlier. …”
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    Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)
  8. 448
    “…We were able to detect EGFR mutations in plasma samples by using an improved PNA-LNA PCR clamp method.…”
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    EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method
  9. 449
    “…Injection of thalassemic mice with SCF plus nanoparticles containing γPNAs and donor DNAs ameliorated the disease phenotype, with sustained elevation of blood haemoglobin levels into the normal range, reduced reticulocytosis, reversal of splenomegaly and up to 7% β-globin gene correction in HSCs, with extremely low off-target effects. …”
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    In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery
  10. 450
    “…Thus, by inhibiting disease related higher order DNA structures in the Frataxin gene, such PNA and LNA oligomers may have potential for discovery of drugs aiming at recovering Frataxin expression.…”
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    Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting
  11. 451
    “…Compared to the corresponding DNA, the PNA zip-code sequence showed a much higher duplex specificity for the complementary DNA sequence. …”
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    Diagnosis of HNF-1α mutations on a PNA zip-code microarray by single base extension
  12. 452
    “…We demonstrate an electrochemical sensor for detection of unlabeled single-stranded DNA using peptide nucleic acid (PNA) probes coupled to the field-effect transistor (FET) gate. …”
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    Real-time wash-free detection of unlabeled PNA-DNA hybridization using discrete FET sensor
  13. 453
    “…This report describes the use of dual gammaPNA (γPNA) probes that hybridize at alternating sites along a telomere and give rise to Förster resonance energy transfer (FRET) signals. …”
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    γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue
  14. 454
    “…Concurrent validity was assessed by ICC and Spearman correlation coefficient between moderate to vigorous PA (MVPA) derived by the PAU-7S and by accelerometer. …”
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    Validity, reliability, and calibration of the physical activity unit 7 item screener (PAU-7S) at population scale
  15. 455
    “…Arginine-rich CPPs efficiently deliver antimicrobial peptide nucleic acid (PNA) to its intracellular mRNA target in bacteria. …”
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    Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli
  16. 456
    “…Dual-labeled PNA probe used RT-LAMP molecular rapid assay targeting SARS-CoV-2 ORF1ab and N genes was developed, and the analytical, clinical performances for detection of SARS-CoV-2 RNA extracted from clinical nasopharyngeal swab specimens were evaluated in this study. …”
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    Development, evaluation of the PNA RT-LAMP assay for rapid molecular detection of SARS-CoV-2
  17. 457
    Materias: “…RNA and RNA-protein complexes…”
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    Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli
  18. 458
    “…Background and Objectives: PNU-74654, a Wnt/β-catenin inhibitor, has reported antitumor activities; however, the therapeutic potential of PNU-74654 in hepatocellular carcinoma (HCC) has not been investigated in detail. …”
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    The Therapeutic Role of PNU-74654 in Hepatocellular Carcinoma May Involve Suppression of NF-κB Signaling
  19. 459
    “…The physical and chemical properties of the outer membrane of Gram-negative bacteria including Escherichia coli have a significant impact on the antibacterial activity and uptake of antibiotics, including antimicrobial peptides and antisense peptide-peptide nucleic acid (PNA) conjugates. Using a defined subset of E. coli lipopolysaccharide (LPS) and envelope mutants, components of the LPS-core, which provide differential susceptibility toward a panel of bacterial penetrating peptide (BPP)-PNA conjugates, were identified. …”
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    Effects of LPS Composition in Escherichia coli on Antibacterial Activity and Bacterial Uptake of Antisense Peptide-PNA Conjugates
  20. 460
    “…The complete mitochondrial DNA genome of the Eurasian Wigeon, Anas penelope, was mapped by the next-generation sequencing and Mega 7.0. …”
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    The complete mitochondrial genome of Anas penelope (Anatidae: Anas)
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