OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

por Marchetti, Carlo, Swartzwelter, Benjamin, Gamboni, Fabia, Neff, Charles P., Richter, Katrin, Azam, Tania, Carta, Sonia, Tengesdal, Isak, Nemkov, Travis, D’Alessandro, Angelo, Henry, Curtis, Jones, Gerald S., Goodrich, Scott A., St. Laurent, Joseph P., Jones, Terry M., Scribner, Curtis L., Barrow, Robert B., Altman, Roy D., Skouras, Damaris B., Gattorno, Marco, Grau, Veronika, Janciauskiene, Sabina, Rubartelli, Anna, Joosten, Leo A. B., Dinarello, Charles A.
Publicado 2018

Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

por Dargaei, Zahra, Bang, Jee Yoon, Mahadevan, Vivek, Khademullah, C. Sahara, Bedard, Simon, Parfitt, Gustavo Morrone, Kim, Jun Chul, Woodin, Melanie A.
Publicado 2018

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells

por Lee, Hyun-Wook, Park, Sung-Hyun, Weng, Mao-wen, Wang, Hsiang-Tsui, Huang, William C., Lepor, Herbert, Wu, Xue-Ru, Chen, Lung-Chi, Tang, Moon-shong
Publicado 2018

Projecting one’s own spatial bias onto others during a theory-of-mind task

por Bio, Branden J., Webb, Taylor W., Graziano, Michael S. A.
Publicado 2018

Farming the mitochondrial ancestor as a model of endosymbiotic establishment by natural selection

por Zachar, István, Szilágyi, András, Számadó, Szabolcs, Szathmáry, Eörs
Publicado 2018

Path integration in place cells of developing rats

por Bjerknes, Tale L., Dagslott, Nenitha C., Moser, Edvard I., Moser, May-Britt
Publicado 2018

Entorhinal fast-spiking speed cells project to the hippocampus

por Ye, Jing, Witter, Menno P., Moser, May-Britt, Moser, Edvard I.
Publicado 2018

Global models underestimate large decadal declining and rising water storage trends relative to GRACE satellite data

por Scanlon, Bridget R., Zhang, Zizhan, Save, Himanshu, Sun, Alexander Y., Müller Schmied, Hannes, van Beek, Ludovicus P. H., Wiese, David N., Wada, Yoshihide, Long, Di, Reedy, Robert C., Longuevergne, Laurent, Döll, Petra, Bierkens, Marc F. P.
Publicado 2018

Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease

por Bennett, Rachel E., Robbins, Ashley B., Hu, Miwei, Cao, Xinrui, Betensky, Rebecca A., Clark, Tim, Das, Sudeshna, Hyman, Bradley T.
Publicado 2018

MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling

por Dzieran, Johanna, Rodriguez Garcia, Aida, Westermark, Ulrica Kristina, Henley, Aine Brigette, Eyre Sánchez, Elena, Träger, Catarina, Johansson, Henrik Johan, Lehtiö, Janne, Arsenian-Henriksson, Marie
Publicado 2018

Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry

por Beer, Katharina B., Rivas-Castillo, Jennifer, Kuhn, Kenneth, Fazeli, Gholamreza, Karmann, Birgit, Nance, Jeremy F., Stigloher, Christian, Wehman, Ann M.
Publicado 2018

Focal versus distributed temporal cortex activity for speech sound category assignment

por Bouton, Sophie, Chambon, Valérian, Tyrand, Rémi, Guggisberg, Adrian G., Seeck, Margitta, Karkar, Sami, van de Ville, Dimitri, Giraud, Anne-Lise
Publicado 2018

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

por Mahgoub, Mohamed, Yasunaga, Jun-ichirou, Iwami, Shingo, Nakaoka, Shinji, Koizumi, Yoshiki, Shimura, Kazuya, Matsuoka, Masao
Publicado 2018

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

por Banfi, Serena, Gusarova, Viktoria, Gromada, Jesper, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2018

The eardrums move when the eyes move: A multisensory effect on the mechanics of hearing

por Gruters, Kurtis G., Murphy, David L. K., Jenson, Cole D., Smith, David W., Shera, Christopher A., Groh, Jennifer M.
Publicado 2018

Evolution of vertical and oblique transmission under fluctuating selection

por Ram, Yoav, Liberman, Uri, Feldman, Marcus W.
Publicado 2018

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a

por Higa, Mitsuru, Oka, Masahiro, Fujihara, Yoshitaka, Masuda, Kazuya, Yoneda, Yoshihiro, Kishimoto, Tadamitsu
Publicado 2018

Endocytosis as a stabilizing mechanism for tissue homeostasis

por Adler, Miri, Mayo, Avi, Zhou, Xu, Franklin, Ruth A., Jacox, Jeremy B., Medzhitov, Ruslan, Alon, Uri
Publicado 2018

Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver

por Wang, Jingkui, Symul, Laura, Yeung, Jake, Gobet, Cédric, Sobel, Jonathan, Lück, Sarah, Westermark, Pål O., Molina, Nacho, Naef, Felix
Publicado 2018

Damaging de novo mutations diminish motor skills in children on the autism spectrum

por Buja, Andreas, Volfovsky, Natalia, Krieger, Abba M., Lord, Catherine, Lash, Alex E., Wigler, Michael, Iossifov, Ivan
Publicado 2018