Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

por Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O. D., Lowe, Edward D., Khoudian, Christina, Smith, Dominique, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado 2012

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

por Artim, Stephen C., Mendrola, Jeannine M., Lemmon, Mark A.
Publicado 2012

2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm

por Lefièvre, Linda, Nash, Katherine, Mansell, Steven, Costello, Sarah, Punt, Emma, Correia, Joao, Morris, Jennifer, Kirkman-Brown, Jackson, Wilson, Stuart M., Barratt, Christopher L. R., Publicover, Stephen
Publicado 2012

The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases

por Bréa, Déborah, Meurens, François, Dubois, Alice V., Gaillard, Julien, Chevaleyre, Claire, Jourdan, Marie-Lise, Winter, Nathalie, Arbeille, Brigitte, Si-Tahar, Mustapha, Gauthier, Francis, Attucci, Sylvie
Publicado 2012

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

por Correa, Ricardo G., Milutinovic, Snezana, Reed, John C.
Publicado 2012

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

por Zhdanov, Alexander V., Dmitriev, Ruslan I., Papkovsky, Dmitri B.
Publicado 2012

Defining the boundaries of species specificity for the Saccharomyces cerevisiae glycosylphosphatidylinositol transamidase using a quantitative in vivo assay

por Morissette, Rachel, Varma, Yug, Hendrickson, Tamara L.
Publicado 2012

Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling

por Guesdon, François, Kaabi, Yahia, Riley, Aiden H., Wilkinson, Ian R., Gray, Colin, James, David C., Artymiuk, Peter J., Sayers, Jon R., Ross, Richard J.
Publicado 2012

The endocrine disruptor mono-(2-ethylhexyl)phthalate promotes adipocyte differentiation and induces obesity in mice

por Hao, Chanjuan, Cheng, Xuejia, Xia, Hongfei, Ma, Xu
Publicado 2012

Overcoming multidrug-resistance in vitro and in vivo using the novel P-glycoprotein inhibitor 1416

por Xu, Yan, Zhi, Feng, Xu, Guangming, Tang, Xiaolei, Lu, Sheng, Wu, Jinhui, Hu, Yiqiao
Publicado 2012

Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae

por Moreno, J. Ignacio, Patlolla, Babu, Belton, Kerry R., Jenkins, Brenita C., Radchenkova, Polina V., Piva, Marta A.
Publicado 2012

An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease

por Hu, Yongmei, Peng, Nan, Han, Wenyuan, Mei, Yuxia, Chen, Zhengjun, Feng, Xu, Liang, Yun Xiang, She, Qunxin
Publicado 2012

Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme

por Ihara, Kentaro, Fujiwara, Noriko, Yamaguchi, Yoshiki, Torigoe, Hidetaka, Wakatsuki, Soichi, Taniguchi, Naoyuki, Suzuki, Keiichiro
Publicado 2012

Solution structure of the strawberry allergen Fra a 1

por Seutter von Loetzen, Christian, Schweimer, Kristian, Schwab, Wilfried, Rösch, Paul, Hartl-Spiegelhauer, Olivia
Publicado 2012

Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients

por Fang, JingXian, Uchiumi, Takeshi, Yagi, Mikako, Matsumoto, Shinya, Amamoto, Rie, Saito, Toshiro, Takazaki, Shinya, Kanki, Tomotake, Yamaza, Haruyoshi, Nonaka, Kazuaki, Kang, Dongchon
Publicado 2012

Extracellular conversion of adiponectin hexamers into trimers

por Kim, Jeong-a, Nuñez, Martha, Briggs, David B., Laskowski, Bethany L., Chhun, Jimmy J., Eleid, Joseph K., Quon, Michael J., Tsao, Tsu-Shuen
Publicado 2012

Mechanisms of bone anabolism regulated by statins

por Ruan, Feng, Zheng, Qiang, Wang, Jinfu
Publicado 2012

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

por Park, Jin H., Liu, Yingting, Lemmon, Mark A., Radhakrishnan, Ravi
Publicado 2012

The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

por Huang, Chun-Hsiang, Sun, Yu, Ko, Tzu-Ping, Chen, Chun-Chi, Zheng, Yingying, Chan, Hsiu-Chien, Pang, Xuefei, Wiegel, Juergen, Shao, Weilan, Guo, Rey-Ting
Publicado 2012

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

por Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado 2012