Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

por Houde, Vanessa P., Ritorto, Maria Stella, Gourlay, Robert, Varghese, Joby, Davies, Paul, Shpiro, Natalia, Sakamoto, Kei, Alessi, Dario R.
Publicado 2014

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

por Birrell, James A., Morina, Klaudia, Bridges, Hannah R., Friedrich, Thorsten, Hirst, Judy
Publicado 2013

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P(3) and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

por Bennett, Hayley J., Davenport, John Bernard, Collins, Richard F., Trafford, Andrew W., Pinali, Christian, Kitmitto, Ashraf
Publicado 2013

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

por Cooper, Christopher D.O., Newman, Joseph A., Gileadi, Opher
Publicado 2014

Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO

por Keusekotten, Kirstin, Bade, Veronika N., Meyer-Teschendorf, Katrin, Sriramachandran, Annie Miriam, Fischer-Schrader, Katrin, Krause, Anke, Horst, Christiane, Schwarz, Günter, Hofmann, Kay, Dohmen, R. Jürgen, Praefcke, Gerrit J. K.
Publicado 2013

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

por Gileadi, Opher
Publicado 2014

Cap-binding complex (CBC)

por Gonatopoulos-Pournatzis, Thomas, Cowling, Victoria H.
Publicado 2013

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

por Mackenzie, Ruth M., Salt, Ian P., Miller, William H., Logan, Angela, Ibrahim, Hagar A., Degasperi, Andrea, Dymott, Jane A., Hamilton, Carlene A., Murphy, Michael P., Delles, Christian, Dominiczak, Anna F.
Publicado 2012

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice

por Bitto, Alessandra, Irrera, Natasha, Minutoli, Letteria, Calò, Margherita, Lo Cascio, Patrizia, Caccia, Paolo, Pizzino, Gabriele, Pallio, Giovanni, Micali, Antonio, Vaccaro, Mario, Saitta, Antonino, Squadrito, Francesco, Altavilla, Domenica
Publicado 2013

The composition of cigarette smoke determines inflammatory cell recruitment to the lung in COPD mouse models

por John, Gerrit, Kohse, Katrin, Orasche, Jürgen, Reda, Ahmed, Schnelle-Kreis, Jürgen, Zimmermann, Ralf, Schmid, Otmar, Eickelberg, Oliver, Yildirim, Ali Önder
Publicado 2013

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870

por Edgar, Alexander J., Trost, Matthias, Watts, Colin, Zaru, Rossana
Publicado 2014

Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition

por Zhao, Hua, Ruberu, Kalani, Li, Hongyun, Garner, Brett
Publicado 2014

Oleate promotes differentiation of chicken primary preadipocytes in vitro

por Shang, Zhouchun, Guo, Lin, Wang, Ning, Shi, Hui, Wang, Yuxiang, Li, Hui
Publicado 2014

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α(2)δ for GPI-anchoring pathways

por Alvarez-Laviada, Anita, Kadurin, Ivan, Senatore, Assunta, Chiesa, Roberto, Dolphin, Annette C.
Publicado 2014

Dynein, microtubule and cargo: a ménage à trois

por Pavin, Nenad, Tolić-Nørrelykke, Iva M.
Publicado 2013

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

por Borodkin, Vladimir S., Schimpl, Marianne, Gundogdu, Mehmet, Rafie, Karim, Dorfmueller, Helge C., Robinson, David A., vanAalten, Daan M. F.
Publicado 2014

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

por Stathopoulou, Konstantina, Cuello, Friederike, Candasamy, Alexandra J., Kemp, Elizabeth M., Ehler, Elisabeth, Haworth, Robert S., Avkiran, Metin
Publicado 2014

The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation

por Lu, Xin-an, Wang, Xiaofeng, Zhuo, Wei, Jia, Lin, Jiang, Yushan, Fu, Yan, Luo, Yongzhang
Publicado 2013

New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

por Canning, Peter, Bullock, Alex N.
Publicado 2014

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

por Bowman, Lisa, Flanagan, Lindsey, Fyfe, Paul K., Parkin, Alison, Hunter, William N., Sargent, Frank
Publicado 2014