RBR E3 ubiquitin ligases: new structures, new insights, new questions

por Spratt, Donald E., Walden, Helen, Shaw, Gary S.
Publicado 2014

Structural basis of conformational transitions in the active site and 80′s loop in the FK506-binding protein FKBP12

por Mustafi, Sourajit M., Brecher, Matthew, Zhang, Jing, Li, Hongmin, Lemaster, David M., Hernández, Griselda
Publicado 2014

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters

por delos Heros, Paola, Alessi, Dario R., Gourlay, Robert, Campbell, David G., Deak, Maria, Macartney, Thomas J., Kahle, Kristopher T., Zhang, Jinwei
Publicado 2014

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways

por Fu, Xueqiong, Feng, Jiarui, Zeng, Duan, Ding, Yu, Yu, Changshou, Yang, Bing
Publicado 2014

Polymorphism of rs873308 near the transmembrane protein 57 gene is associated with serum lipid levels

por Guo, Tao, Yin, Rui-Xing, Lin, Quan-Zhen, Wu, Jian, Shen, Shao-Wen, Sun, Jia-Qi, Shi, Guang-Yuan, Wu, Jin-Zhen, Li, Hui, Wang, Yi-Ming
Publicado 2014

A new glycation product ‘norpronyl-lysine,’ and direct characterization of cross linking and other glycation adducts: NMR of model compounds and collagen

por Bullock, Peter T. B., Reid, David G., Ying Chow, W., Lau, Wendy P. W., Duer, Melinda J.
Publicado 2014

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

por Chaikuad, Apirat, Keates, Tracy, Vincke, Cécile, Kaufholz, Melanie, Zenn, Michael, Zimmermann, Bastian, Gutiérrez, Carlos, Zhang, Rong-guang, Hatzos-Skintges, Catherine, Joachimiak, Andrzej, Muyldermans, Serge, Herberg, Friedrich W., Knapp, Stefan, Müller, Susanne
Publicado 2014

The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription

por Trembley, Michael A., Berrus, Hunter L., Whicher, Jonathan R., Humphrey-Dixon, Emily L.
Publicado 2014

DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

por Zerenturk, Eser J., Sharpe, Laura J., Brown, Andrew J.
Publicado 2014

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

por Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Publicado 2014

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

por Whittle, Nigel, Singewald, Nicolas
Publicado 2014

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)

por Glover, Mark, Ware, James S., Henry, Amanda, Wolley, Martin, Walsh, Roddy, Wain, Louise V., Xu, Shengxin, Van’t Hoff, William G., Tobin, Martin D., Hall, Ian P., Cook, Stuart, Gordon, Richard D., Stowasser, Michael, O’Shaughnessy, Kevin M.
Publicado 2014

Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

por Kitevska, Tanja, Roberts, Sarah J., Pantaki-Eimany, Delara, Boyd, Sarah E., Scott, Fiona L., Hawkins, Christine J.
Publicado 2014

Phosphorylation of Arabidopsis transketolase at Ser(428) provides a potential paradigm for the metabolic control of chloroplast carbon metabolism

por Rocha, Agostinho G., Mehlmer, Norbert, Stael, Simon, Mair, Andrea, Parvin, Nargis, Chigri, Fatima, Teige, Markus, Vothknecht, Ute C.
Publicado 2014

N-terminus oligomerization is conserved in intracellular calcium release channels

por Zissimopoulos, Spyros, Marsh, Jason, Stannard, Laurence, Seidel, Monika, Lai, F. Anthony
Publicado 2014

Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

por Gómez, Isabel, Sánchez, Jorge, Muñoz-Garay, Carlos, Matus, Violeta, Gill, Sarjeet S., Soberón, Mario, Bravo, Alejandra
Publicado 2014

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

por Butt, Aaron, Higman, Victoria A., Williams, Christopher, Crump, Matthew P., Hemsley, Claudia M., Harmer, Nicholas, Titball, Richard W.
Publicado 2014

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

por Banerjee, Sourav, Buhrlage, Sara J., Huang, Hai-Tsang, Deng, Xianming, Zhou, Wenjun, Wang, Jinhua, Traynor, Ryan, Prescott, Alan R., Alessi, Dario R., Gray, Nathanael S.
Publicado 2013

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

por Roberts, Adam J., Torrie, Leah S., Wyllie, Susan, Fairlamb, Alan H.
Publicado 2014

Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species

por Phansopa, Chatchawal, Roy, Sumita, Rafferty, John B., Douglas, C. W. Ian, Pandhal, Jagroop, Wright, Phillip C., Kelly, David J., Stafford, Graham P.
Publicado 2014