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  1. 1261
    “…METHODOLOGY/PRINCIPAL FINDINGS: Using immunohistochemical analyses, we show that ghrelin, a hormone classically considered to be an appetite-regulating hormone, is present within the taste buds of the tongue. Prepro-ghrelin, prohormone convertase 1/3 (PC 1/3), ghrelin, its cognate receptor (GHSR), and ghrelin-O-acyltransferase (GOAT , the enzyme that activates ghrelin) are expressed in Type I, II, III and IV taste cells of mouse taste buds. …”
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    Ghrelin Is Produced in Taste Cells and Ghrelin Receptor Null Mice Show Reduced Taste Responsivity to Salty (NaCl) and Sour (Citric Acid) Tastants
  2. 1262
    por Gäde, Gerd, Marco, Heather G.
    Publicado 2011
    “…We hypothesise on the molecular evolution of Emppe-AKH and Peram-CAH-II from the ancestral peptide due to nonsynonymous missense single nucleotide polymorphism in the nucleotide coding sequence of prepro-AKH. Finally, we review the biological significance of the AKH peptides as hyperprolinaemic hormones in Chrysomeloidea, i.e. they cause an increase in the circulating concentration of proline. …”
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    The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
  3. 1263
    “…Complementary DNA cloning revealed the barfin flounder prepro-ghrelin to be a 106-aa peptide and the mature ghrelin to be a 20-aa peptide (GSSFLSPSHKPPNKGKPPRA). …”
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    Determination of Ghrelin Structure in the Barfin Flounder (Verasper moseri) and Involvement of Ingested Fatty Acids in Ghrelin Acylation
  4. 1264
    “…NOX-G15 shows no cross-reactivity with related peptides such as glucagon-like peptide-1, glucagon-like peptide-2, gastric-inhibitory peptide, and prepro-vasoactive intestinal peptide. In vitro, NOX-G15 inhibits glucagon-stimulated cAMP production in CHO cells overexpressing the human glucagon receptor with an IC(50) of 3.4 nm. …”
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    A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes
  5. 1265
    “…MDMA induced a reduction in ERK1/2 immunoreactivity in the frontal cortex of male but not female animals, and THC decreased prepro-orexin mRNA levels in the hypothalamus of males, although this effect was prevented when the animals also received MDMA. …”
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    Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption
  6. 1266
    “…In the injury area, expression of prepro-ET-1 mRNA and ET-1 peptide increased. Intracerebroventricular (ICV) administration of BQ788 (ET(B) antagonist), IRL-2500 (ET(B) antagonist), or FR139317 (ET(A) antagonist) prior to cold injury significantly attenuated the increase in brain water content. …”
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    Amelioration of Cold Injury-Induced Cortical Brain Edema Formation by Selective Endothelin ET(B) Receptor Antagonists in Mice
  7. 1267
    por Maguire, J J, Davenport, A P
    Publicado 2014
    “…The ET-like domain peptide, corresponding to prepro-ET-1(93–166), has been proposed to be co-synthesized and released with ET-1, to modulate the actions of the peptide. …”
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    Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12
  8. 1268
    “…Enforced expression of miR-132 results in a block in early B cell development at the prepro–B cell to pro–B cell transition and induces apoptosis in primary bone marrow B cells. …”
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    The microRNA-212/132 cluster regulates B cell development by targeting Sox4
  9. 1269
    “…Modulation of the expression of brain neuropeptides and receptors including NPY, POMC, AgRP, cocaine- and amphetamine related transcript (CART), corticotropin-releasing hormone (CRH) and prepro-orexin (HCRT), and Y(2) and Y(5) neuropeptide Y, MC(4) (melanocortin), OX(1) and OX(2) orexin receptors (Y(2)R, Y(5)R, MC(4)R, OX(1)R and OX(2)R, respectively) was also explored. …”
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    Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice
  10. 1270
    “…Mechanical hyperalgesia and thermal hyperalgesia, paw edema, and mRNA expression of peripheral and spinal cord mediators involved in inflammatory pain, TNFα, IL-1β, IL-10, COX-2, preproET-1, gp91(phox), Nrf2, GFAP, and Iba-1, were evaluated. …”
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    Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice
  11. 1271
    “…We found that the propeptide cleaved from prepro-PIV was co-purified with M-PIV, but never with P-PIV. …”
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    Post-secretional activation of Protease IV by quorum sensing in Pseudomonas aeruginosa
  12. 1272
    “…Western blot analysis demonstrated markedly elevated levels of prepro-endothelin-1 and survivin as well as decreased endothelial nitric oxide synthase phosphorylation in the lung tissue of the MRL/lpr mice. …”
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    Autoimmune disease mouse model exhibits pulmonary arterial hypertension
  13. 1273
    “…Based on our immunofluorescence analysis, none of the 56 Pandemrix-vaccinated narcoleptic patients, 28 patients who suffered from a laboratory-confirmed H1N1pdm09 infection or 19 Pandemrix-vaccinated controls showed specific autoantibody responses to prepro-orexin, orexin receptors or the isolated extracellular N-termini of orexin receptors. …”
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    No evidence of autoimmunity to human OX(1) or OX(2) orexin receptors in Pandemrix-vaccinated narcoleptic children
  14. 1274
    “…Since new vessel growth is crucial for ovarian follicle development, a further aim of this study was to explore the expression of prepro-orexin and the effects of OXB on swine aortic endothelial cells. …”
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    Effects of Orexin B on Swine Granulosa and Endothelial Cells
  15. 1275
    “…We used transgenic mice in which the vesicular glutamate transporter 2 gene was disrupted selectively in orexin-producing neurons (ORX;vGT2-KO), prepro-orexin knockout mice (ORX-KO), and control wild type mice (WT). …”
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    Multifaceted roles of orexin neurons in mediating methamphetamine-induced changes in body temperature and heart rate
  16. 1276
    por Cheshkova, A.F.
    Publicado 2022
    “…The review describes the main steps of the hyperspectral data analysis process: image acquisition and prepro cessing; data extraction and processing; modeling and analysis of data. …”
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    A review of hyperspectral image analysis techniques for plant disease detection and identif ication
  17. 1277
    “…Macitentan lowered the increased levels of atrial ET-1 and abrogated the pacing-induced upregulation of preproET-1-mRNA in atrial slices from SHR. Macitentan reduced the elevated levels of atrial 8-isoprostanes, the increased expression of pro-inflammatory ICAM-1 and IL-8, the phosphorylation of MAP kinases, ERK and p38, the phosphorylation of NF-κB and the expression of VCAM-mRNA. …”
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    Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats
  18. 1278
    “…Hepcidin biosynthesis involves the N-terminally extended precursors prepro-hepcidin and pro-hepcidin, processed by peptidases to the final 25-peptide form. …”
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    An Overlooked Hepcidin–Cadmium Connection
  19. 1279
    “…Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. …”
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    Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
  20. 1280
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    Dark matter search in missing energy events with NA64
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