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2701por Antico Arciuch, Valeria Gabriela, Galli, Soledad, Franco, María Clara, Lam, Philip Y., Cadenas, Enrique, Carreras, María Cecilia, Poderoso, Juan José“…These results indicate that Akt1 intramitochondrial-cycling is central for redox modulation of cell fate.…”
Publicado 2009
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2702“…However, recent in vitro studies have indicated that GTPases may also be directly regulated by redox agents. We hypothesized that this redox-based mechanism occurs in cells and affects cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA. …”
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2703“…Analogy to cocaine metabolites suggests participation of redox entities, such as, hydroxylamine, nitroxide and nitrosonium, which can lead to electron transfer and radical formation. …”
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2704por Igosheva, Natalia, Abramov, Andrey Y., Poston, Lucilla, Eckert, Judith J., Fleming, Tom P., Duchen, Michael R., McConnell, Josie“…Generation of reactive oxygen species (ROS) was raised while glutathione was depleted and the redox state became more oxidised, suggestive of oxidative stress. …”
Publicado 2010
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2706“…BACKGROUND: The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. …”
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2707por Choi, Hye-Ryung, Shin, Jung-Won, Lee, Hyun-Kyoung, Kim, Jin-Young, Huh, Chang-Hun, Youn, Sang-Woong, Park, Kyoung Chan“…Finally, LY294002 exerted a protective effect against DA-induced apoptotic cell death. DA may induce redox-sensitive Akt activation and increase the level of Bad, which can promote cell death by heterodimerization with survival proteins. …”
Publicado 2010
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2708por Yan, Shan, Sun, Xuxu, Xiang, Binggang, Cang, Hui, Kang, Xunlei, Chen, Yuying, Li, Hui, Shi, Guiying, Yeh, Edward T H, Wang, Beilei, Wang, Xiangrui, Yi, Jing“…Our data demonstrate for the first time that CHIP and Hsp90 interplay with a client alternately under non-stress and stress conditions, and the choice between stabilization and degradation is made by the redox state of the client. In addition, enhanced SENP3/Hsp90 association is found in cancer. …”
Publicado 2010
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2709por Shin, Dong-Min, Jeon, Bo-Young, Lee, Hye-Mi, Jin, Hyo Sun, Yuk, Jae-Min, Song, Chang-Hwa, Lee, Sang-Hee, Lee, Zee-Won, Cho, Sang-Nae, Kim, Jin-Man, Friedman, Richard L., Jo, Eun-Kyeong“…Collectively, these data indicate that Mtb Eis suppresses host innate immune defenses by modulating autophagy, inflammation, and cell death in a redox-dependent manner.…”
Publicado 2010
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2710por PASSAM, F H, RAHGOZAR, S, QI, M, RAFTERY, M J, WONG, J W H, TANAKA, K, IOANNOU, Y, ZHANG, J Y, GEMMELL, R, QI, J C, GIANNAKOPOULOS, B, HUGHES, W E, HOGG, P J, KRILIS, S A“…Conclusions: Given the importance of thiol oxidoreductases in thrombus formation, we provide preliminary evidence that the thiol-dependent interaction of β(2)GPI with VWF may contribute to the redox regulation of platelet adhesion.…”
Publicado 2010
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2711por Lakhal, Raja, Auria, Richard, Davidson, Sylvain, Ollivier, Bernard, Dolla, Alain, Hamdi, Moktar, Combet-Blanc, Yannick“…When grown anaerobically on glucose, T. maritima was shown to significantly decrease the redox potential (Eh) of the culture medium down to about −480 mV, as long as glucose was available. …”
Publicado 2010
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2713por Speisky, Hernán, López-Alarcón, Camilo, Olea-Azar, Claudio, Sandoval-Acuña, Cristian, Aliaga, Margarita E.“…We addressed here the effects that superoxide removal has on the redox state of Cu(I) and GSH present in such complex and assessed the formation of Cu(II)-GSSG as a final oxidation product. …”
Publicado 2011
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2714Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cellspor Grüning, Nana-Maria, Rinnerthaler, Mark, Bluemlein, Katharina, Mülleder, Michael, Wamelink, Mirjam M.C., Lehrach, Hans, Jakobs, Cornelis, Breitenbach, Michael, Ralser, Markus“…Studying its regulator pyruvate kinase (PYK) in yeast, we discovered that central metabolism is self-adapting to synchronize redox metabolism when respiration is activated. Low PYK activity activated yeast respiration. …”
Publicado 2011
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2715por Wang, Conan K., Simon, Anne, Jessen, Christian M., Oliveira, Cristiano L. P., Mack, Lynsey, Braunewell, Karl-Heinz, Ames, James B., Pedersen, Jan Skov, Hofmann, Andreas“…Analysis of the quaternary structure of VILIP-1 in solution reveals the existence of monomeric and dimeric species, the relative contents of which are affected but not exclusively regulated by divalent metal ions and Redox conditions. Using small-angle X-ray scattering, we have investigated the low resolution structure of the calcium-bound VILIP-1 dimer under reducing conditions. …”
Publicado 2011
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2716“…Recently we reported that both PKA and PKG can be regulated independently of their respective cyclic nucleotides via a mechanism whereby the kinases sense cellular oxidant production using redox active thiols. This novel redox regulation of these kinases is potentially of physiological importance, and may synergise with the classical regulatory mechanisms.…”
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2717por Korga, Agnieszka, Dudka, Jaroslaw, Burdan, Franciszek, Sliwinska, Justyna, Mandziuk, Slawomir, Dawidek-Pietryka, Katarzyna“…In conclusion, an increase of tetraiodothyronine level may be an additional risk factor of redox imbalance and RyR2 reduction in anthracycline cardiotoxicity.…”
Publicado 2012
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2718por Shelobolina, Evgenya, Konishi, Hiromi, Xu, Huifang, Benzine, Jason, Xiong, Mai Yia, Wu, Tao, Blöthe, Marco, Roden, Eric“…The biogeochemistry of phyllosilicate–Fe redox cycling was studied in a Phalaris arundinacea (reed canary grass) dominated redoximorphic soil from Shovelers Sink, a small glacial depression near Madison, WI. …”
Publicado 2012
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2719por Manna, Alak, Saha, Piu, Sarkar, Avijit, Mukhopadhyay, Debanjan, Bauri, Ajay K., Kumar, Deepak, Das, Padma, Chattopadhyay, Subrata, Chatterjee, Mitali“…BACKGROUND: The ‘two-faced’ character of reactive oxygen species (ROS) plays an important role in cancer biology by acting both as secondary messengers in intracellular signaling cascades and sustaining the oncogenic phenotype of cancer cells, while on the other hand, it triggers an oxidative assault that causes a redox imbalance translating into an apoptotic cell death. …”
Publicado 2012
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