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2981por Duan, Jicheng, Zhang, Tong, Gaffrey, Matthew J., Weitz, Karl K., Moore, Ronald J., Li, Xiaolu, Xian, Ming, Thrall, Brian D., Qian, Wei-Jun“…Posttranslational modifications of protein cysteine thiols play a significant role in redox regulation and the pathogenesis of human diseases. …”
Publicado 2020
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2982“…BACKGROUND: Several studies have highlighted the substantial role of the athlete’s redox and inflammation status during the training process. …”
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2983por Villarreal, Cristiane F., Santos, Dourivaldo S., Lauria, Pedro S. S., Gama, Kelly B., Espírito-Santo, Renan F., Juiz, Paulo J. L., Alves, Clayton Q., David, Jorge M., Soares, Milena B. P.“…The long-lasting antinociceptive effect induced by bergenin in neuropathic mice, was associated with a shift of the cytokine balance toward anti-inflammatory predominance and upregulation of antioxidant pathways, favoring the reestablishment of redox and immune homeostasis in the nervous system. …”
Publicado 2020
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2984por Hrelia, Patrizia, Sita, Giulia, Ziche, Marina, Ristori, Emma, Marino, Angela, Cordaro, Marika, Molteni, Raffaella, Spero, Vittoria, Malaguti, Marco, Morroni, Fabiana, Hrelia, Silvana“…This review is aimed at characterizing the complex network of molecular mechanisms underpinning acute and chronic neurodegeneration, focusing on the disturbance in redox homeostasis, as a common mechanism behind five pivotal risk factors: aging, oxidative stress, inflammation, glycation, and vascular injury. …”
Publicado 2020
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2985“…Mitochondrial dysfunction impairs redox homeostasis and metabolic adaptation, leading to aging and metabolic disorders like insulin resistance and type 2 diabetes. …”
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2986por Grundler, Franziska, Mesnage, Robin, Goutzourelas, Nikolaos, Tekos, Fotios, Makri, Sotiria, Brack, Michel, Kouretas, Demetrios, Wilhelmi de Toledo, Françoise“…There was an interplay between redox and metabolic parameters since lipid peroxidation baseline levels (thiobarbituric acid reactive substances [TBARS]) affected the ability of long-term fasting to normalize lipid levels. …”
Publicado 2020
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2987Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance“…Here, we report that after high-fat diet (HFD) feeding for 16 weeks, myeloid-specific FBW7-deficient mice demonstrate increased redox stress, inflammatory responses and insulin resistance. …”
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2988“…This rapid complexity generating route paves the way toward various dihydroindole Aspidosperma alkaloids with different C-5 side chain redox patterns. The end-game redox modulations were accomplished by modified Wolff–Kishner reaction and photo-Wolff rearrangement, enabling the total synthesis of (−)-aspidospermidine, (−)-limaspermidine, and (+)-17-demethoxy-N-acetylcylindrocarine and the formal total synthesis of (−)-1-acetylaspidoalbidine.…”
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2989por Finelli, Mattéa J.“…RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. …”
Publicado 2020
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2990por Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo“…Mechanistically, accumulation of mtDNA mutations decreases fertility by impairing oocyte's NADH/NAD(+) redox state, which could be rescued by nicotinamide mononucleotide treatment. …”
Publicado 2020
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2991“…To improve the NIB capacity and retainability, extensive efforts have been put into the developments of NIB electrode materials. The redox activities of the transition metal (TM)-based NIB electrodes are critical in defining the capacity and stability. …”
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2992por Sikora, Adam, Zielonka, Jacek, Dębowska, Karolina, Michalski, Radosław, Smulik-Izydorczyk, Renata, Pięta, Jakub, Podsiadły, Radosław, Artelska, Angelika, Pierzchała, Karolina, Kalyanaraman, Balaraman“…The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments.…”
Publicado 2020
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2993“…It is notable that sirtuin proteins are impaired in aged hearts and are critical to maintaining redox homeostasis via regulating substrate metabolism and inflammation and thus preserving cardiac function under stress. …”
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2994por Li, Hongdong, Han, Yi, Zhao, Huan, Qi, Wenjing, Zhang, Dan, Yu, Yaodong, Cai, Wenwen, Li, Shaoxiang, Lai, Jianping, Huang, Bolong, Wang, LeiEnlace del recurso
Publicado 2020
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2996por Bakalova, Rumiana, Semkova, Severina, Ivanova, Donika, Zhelev, Zhivko, Miller, Thomas, Takeshima, Tsuguhide, Shibata, Sayaka, Lazarova, Dessislava, Aoki, Ichio, Higashi, Tatsuya“…Redox-active substances and their combinations, such as of quinone/ascorbate and in particular menadione/ascorbate (M/A; also named Apatone®), attract attention with their unusual ability to kill cancer cells without affecting the viability of normal cells as well as with the synergistic anticancer effect of both molecules. …”
Publicado 2020
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2997por Xin, Xiaofei, Kumar, Virender, Lin, Feng, Kumar, Vinod, Bhattarai, Rajan, Bhatt, Vijaya R., Tan, Chalet, Mahato, Ram I.“…We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant pancreatic cancer cells inhibited HIF-1α level under hypoxia. We synthesized redox-sensitive mPEG-co-P(Asp)-g-DC-g-S-S-GEM polymer, with GEM payload of 14% (w/w) and 90% GEM release upon incubation with l-glutathione. …”
Publicado 2020
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2998por Kocic, H., Langerholc, T., Kostic, M., Stojanovic, S., Najman, S., Krstic, M., Nesic, I., Godic, A., Wollina, U.“…Their effects on the growth-regulatory kinases and redox-sensitive, proinflammatory transcriptional factor NF-κB were detected by using specific primary antibodies against NF-κB p65, Akt-1, phospho-Akt-1, Erk-1, phospho-Erk-1, JNK, phospho-JNK, phospho-STAT-1, and CD26, while logarithmic integrated fluorescence intensity patterns were recorded by flow cytometry. …”
Publicado 2020
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2999“…Hypothesis: early-life oxidative stress characterized by the redox potential of glutathione influences the DNA methylation level. …”
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3000por Li, Huige, Kilgallen, Aoife B., Münzel, Thomas, Wolf, Eva, Lecour, Sandrine, Schulz, Rainer, Daiber, Andreas, Van Laake, Linda W.“…We provide an overview on the impact of the external exposome comprising risk factors/exposures on cardiovascular health with a focus on dysregulation of stress hormones, mitochondrial function, redox balance and inflammation with special emphasis on the circadian clock. …”
Publicado 2020
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