“…We hypothesize here that the cytosolic pH may coordinate mitochondrial activity and thus the different redox cycles, which in turn control the cell metabolism.…”
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“…Mitochondria have long been assumed to play the primary role in generation of superoxide in muscle, but recent studies indicate that, during contractile activity, membrane-localized NADPH oxidase(s) rapidly generate(s) superoxide that plays a role in redox signaling. This process is important in upregulation of rapid and specific cytoprotective responses that aid maintenance of cell viability following contractile activity, but the overall extent to which redox signaling contributes to regulation of muscle metabolism and homeostasis following contractile activity is currently unclear, as is identification of key redox-sensitive protein targets involved in these processes. …”
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“…It results in cysteine being present in several distinct redox forms inside the cell. Amongst these, reversible oxidations, S-nitrosylation and S-sulfenylation are crucial mediators of intracellular redox signalling, with known associations to health and disease. …”
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“…Reactive oxygen species, known to play crucial roles in PTI and ETI, can perturb cellular redox homeostasis and lead to changes of redox-sensitive proteins through modification of cysteine sulfhydryl groups. …”
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“…[Image: see text] Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. …”
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“…Our results indicate that Ediacaran marine redox chemistry was highly heterogeneous, even at the kilometre-scale. …”
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“…RESULTS: Based on the current results, rat thyroid PC Cl3, PC PTC1, PC E1A, or FRLT5 cell models can be used to study NOX2, NOX4, SOD2, SOD3, CATALASE, GPX1, GPX2, GPX5, PRDX2, and PRDX3 gene expression and function. CONCLUSIONS: Redox gene expression in rat originated single cell model systems used to study human thyroid carcinogenesis corresponds only partly with human redox gene expression, which may be caused by differences in redox gene activation stimulus. …”
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“…This implicates PRDX as an ‘active’ redox relay in transmitting the oxidising equivalent of H(2)O(2) to downstream proteins. …”
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“…PURPOSE OF REVIEW: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. …”
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“…[Image: see text] The development of new redox polymers is being boosted by the increasing interest in the area of energy and health. …”
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“…Here we discuss two major types of PTMs, protein phosphorylation and redox modification that play essential roles in stomatal movement under stress conditions. …”
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“…Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. …”
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“…Mitochondria and other redox-active enzymes can generate superoxide and hydrogen peroxide as a by-product in liver cells. …”
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“…Differential responses observed in the absence of an electron donor and over varying potentials suggest a redox driven conductivity mechanism in mixed-species biofilms. …”
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“…Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. …”
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