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1801“…Mutant p53 proteins can acquire so called gain-of-function activities and influence the cellular redox balance in various ways, for instance by binding of the Nrf2 transcription factor, a major regulator of cellular redox state. …”
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1802por Miura, Makoto, Sugiyama, Atsushi, Oshikiri, Yoshinobu, Morimoto, Ryoichi, Mogi, Iwao, Miura, Miki, Takagi, Satoshi, Kim, Jeonghun, Yamauchi, Yusuke, Aogaki, RyoichiEnlace del recurso
Publicado 2019
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1803“…To achieve this goal, redox nanodomains in the ER and the interorganellar cleft influence the activities of ER chaperones and Ca(2+)-handling proteins to signal to mitochondria. …”
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1804por Yang, Hung-Chi, Wu, Yi-Hsuan, Yen, Wei-Chen, Liu, Hui-Ya, Hwang, Tsong-Long, Stern, Arnold, Chiu, Daniel Tsun-Yee“…The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. …”
Publicado 2019
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1805por McFarlane, Ciaran R., Shah, Nita R., Kabasakal, Burak V., Echeverria, Blanca, Cotton, Charles A. R., Bubeck, Doryen, Murray, James W.“…GAPDH and PRK are coregulated by the redox state of a conditionally disordered protein CP12, which forms a ternary complex with both enzymes. …”
Publicado 2019
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1806“…Here we show their common origin is an electrochemical reaction driven by redox couples of oxygen and water molecules. Using real-time photoluminescence imaging of WS(2) and Raman spectroscopy of graphene, we capture molecular diffusion through the two-dimensional nanoscopic space between two-dimensional materials and hydrophilic substrates, and show that the latter accommodate water molecules also serving as a hydrating solvent. …”
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1807por Smith, Tyler K. T., Kahiel, Zaina, LeBlond, Nicholas D., Ghorbani, Peyman, Farah, Eliya, Al-Awosi, Refel, Cote, Marceline, Gadde, Suresh, Fullerton, Morgan D.“…We observed little difference in the base characteristics of standard PLGA-PEG NP when compared to two redox-active polymeric NP formulations, which we called redox-responsive (RR)1 and RR2. …”
Publicado 2019
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1808por Bellafiore, Marianna, Bianco, Antonino, Battaglia, Giuseppe, Naccari, Maria Silvia, Caramazza, Giovanni, Padulo, Johnny, Chamari, Karim, Paoli, Antonio, Palma, Antonio“…High oxidative stress induced by an HI protocol might be associated with both insufficient TAC and recovery time at 48 h necessary to restore redox balance.…”
Publicado 2019
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1809por Reynolds, M. F., Guimarães, M. H. D., Gao, H., Kang, K., Cortese, A. J., Ralph, D. C., Park, J., McEuen, P. L.“…Measuring the behavior of redox-active molecules in space and time is crucial for understanding chemical and biological systems and for developing new technologies. …”
Publicado 2019
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1810por Worley, Beth L., Kim, Yeon Soo, Mardini, Jennifer, Zaman, Rameez, Leon, Kelly E., Vallur, Piyushi Gupta, Nduwumwami, Asvelt, Warrick, Joshua I., Timmins, Patrick F., Kesterson, Joshua P., Phaëton, Rébécca, Lee, Nam Y., Walter, Vonn, Endres, Lauren, Mythreye, Karthikeyan, Aird, Katherine M., Hempel, Nadine“…However, little is known about the redox status of ascites, or whether antioxidant enzymes are required to support ovarian cancer survival during transcoelomic metastasis in this medium. …”
Publicado 2018
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1811“…On the basis of illustrating the relationship between ROS and cancer, the current review discusses the composition and efficacy of tea including the redox-relative (including anti-oxidative and pro-oxidative activity) mechanisms and their role along with other components in preventing and treating cancer. …”
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1812por Forcina, Laura, Miano, Carmen, Scicchitano, Bianca M., Rizzuto, Emanuele, Berardinelli, Maria Grazia, De Benedetti, Fabrizio, Pelosi, Laura, Musarò, Antonio“…Our findings are coherent with a model in which uncontrolled levels of IL-6 in the bloodstream can influence the local redox homeostasis, inducing the establishment of prooxidative conditions in skeletal muscle tissue.…”
Publicado 2019
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1813por Li, Fu, Huang, Zhao, Chen, Huitong, Yan, Lu, Li, Jin, Su, Yue, Zhang, Qian, Huang, Zhengye, Zheng, Yaxin“…Therapeutic application of unmodified camptothecin (CPT) is severely restricted by its extremely low water solubility and the instability of active lactone ring. In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT for the improved antitumor efficacy. …”
Publicado 2019
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1814“…Thiol-based redox regulation is a posttranslational protein modification that plays a key role in adjusting chloroplast functions in response to changing light conditions. …”
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1815“…Despite the convincing empirical evidence that deuterium depleted water (DDW, 25–125 ppm deuterium) has anticancer effect, the molecular mechanism remains unclear. Here, redox proteomics investigation of the DDW action in A549 cells revealed an increased level of oxidative stress, whereas expression proteomics in combination with thermal profiling uncovered crucial role of mitochondrial proteins. …”
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1816por Kochlik, Bastian, Stuetz, Wolfgang, Pérès, Karine, Pilleron, Sophie, Féart, Catherine, García García, Francisco José, Bandinelli, Stefania, Gomez‐Cabrero, David, Rodriguez‐Mañas, Leocadio, Grune, Tilman, Weber, DanielaEnlace del recurso
Publicado 2019
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1817“…NAD(+)/NADH redox state has been implicated in many diseases such as cancer and diabetes as well as in the regulation of embryonic development and aging. …”
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1818Fibroblasts to Keratinocytes Redox Signaling: The Possible Role of ROS in Psoriatic Plaque Formationpor Barygina, Victoria, Becatti, Matteo, Prignano, Francesca, Lotti, Torello, Taddei, Niccolò, Fiorillo, Claudia“…Collectively, our data demonstrate that NOX4 expressed in dermal fibroblasts is essential for the redox paracrine regulation of epidermal keratinocytes proliferation.…”
Publicado 2019
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1819por Mourenza, Álvaro, Bravo-Santano, Natalia, Pradal, Inés, Gil, Jose A., Mateos, Luis M., Letek, Michal“…Experiments with the reduction-oxidation sensitive green fluorescent protein 2 (roGFP2) biosensor confirmed that R. equi was exposed to redox stress during phagocytosis, and mycoredoxins were involved in preserving the redox homeostasis of the pathogen. …”
Publicado 2019
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1820por Lo Dico, Alessia, Salvatore, Daniela, Martelli, Cristina, Ronchi, Dario, Diceglie, Cecilia, Lucignani, Giovanni, Ottobrini, LuisaEnlace del recurso
Publicado 2019
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