Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations

por Bai, Zixuan, Wang, Jiewen, Li, Jiaqi, Yuan, Haibin, Wang, Ping, Zhang, Miao, Feng, Yuanhang, Cao, Xiangtong, Cao, Xiangan, Kang, Guangbo, de Marco, Ario, Huang, He
Publicado 2022

MUG: A mutation overview of GPCR subfamily A17 receptors

por Caniceiro, Ana B., Bueschbell, Beatriz, Barreto, Carlos A.V., Preto, António J., Moreira, Irina S.
Publicado 2022

Histone H2Bub dynamics in the 5′ region of active genes are tightly linked to the UV-induced transcriptional response

por Fanourgakis, Smaragda, Synacheri, Anna-Chloe, Lavigne, Matthieu D., Konstantopoulos, Dimitris, Fousteri, Maria
Publicado 2022

Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein

por Olotu, Fisayo, Medina-Carmona, Encarnacion, Serrano-Sanchez, Angela, Ossa, Felipe, El-Hamdaoui, Abdelaziz, Bishop, Özlem Tastan, Ortega-Roldan, Jose L., Abdul-Salam, Vahitha B.
Publicado 2022

Integrated mRNA and miRNA transcriptomic analysis reveals the response of Rapana venosa to the metamorphic inducer (juvenile oysters)

por Yang, Mei-Jie, Song, Hao, Shi, Pu, Liang, Jian, Hu, Zhi, Zhou, Cong, Hu, Peng-Peng, Yu, Zheng-Lin, Zhang, Tao
Publicado 2022

Dynamic gene screening enabled identification of a 10-gene panel for early detection and progression assessment of gastric cancer

por Long, Fei, Li, Shuo, Xu, Yaqi, Liu, Min, Zhang, Xuan, Zhou, Junting, Chen, Yiyi, Rong, Yuan, Meng, Xiangyu, Wang, Fubing
Publicado 2022

Beyond sequence: Structure-based machine learning

por Durairaj, Janani, de Ridder, Dick, van Dijk, Aalt D.J.
Publicado 2022

Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues

por Zhang, Jiayu, Lu, Tong, Lu, Shiqi, Ma, Shuaijun, Han, Donghui, Zhang, Keying, Xu, Chao, Liu, Shaojie, Gan, Lunbiao, Wu, Xinjie, Yang, Fa, Wen, Weihong, Qin, Weijun
Publicado 2022

Analysis of a C. elegans lifespan prediction method based on a bimodal neural network and uncertainty estimation()

por García-Garví, Antonio, Layana-Castro, Pablo E., Sánchez-Salmerón, Antonio-José
Publicado 2022

CNN6mA: Interpretable neural network model based on position-specific CNN and cross-interactive network for 6mA site prediction

por Tsukiyama, Sho, Hasan, Md Mehedi, Kurata, Hiroyuki
Publicado 2022

eMIC-AntiKP: Estimating minimum inhibitory concentrations of antibiotics towards Klebsiella pneumoniae using deep learning

por Nguyen, Quang H., Ngo, Hoang H., Nguyen-Vo, Thanh-Hoang, Do, Trang T.T., Rahardja, Susanto, Nguyen, Binh P.
Publicado 2022

Cell segmentation and representation with shape priors

por Hirling, Dominik, Horvath, Peter
Publicado 2022

Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease

por Ahmed, Ikhlak, Ziab, Mubarak, Da’as, Sahar, Hasan, Waseem, Jeya, Sujitha P., Aliyev, Elbay, Nisar, Sabah, Bhat, Ajaz A., Fakhro, Khalid Adnan, Alshabeeb Akil, Ammira S.
Publicado 2023

EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

por Semyachkina-Glushkovskaya, O.V., Karavaev, A.S., Prokhorov, M.D., Runnova, A.E., Borovkova, E.I., Yu.M., Ishbulatov, Hramkov, A.N., Kulminskiy, D.D., Semenova, N.I., Sergeev, K.S., Slepnev, A.V., Yu., Sitnikova E., Zhuravlev, M.O., Fedosov, I.V., Shirokov, A.A., Blokhina, I.A., Dubrovski, A.I., Terskov, A.V., Khorovodov, A.P., Ageev, V.B., Elovenko, D.A., Evsukova, A.S., Adushkina, V.V., Telnova, V.V., Postnov, D.E., Penzel, T.U., Kurths, J.G.
Publicado 2022

Network-based approaches for modeling disease regulation and progression

por Galindez, Gihanna, Sadegh, Sepideh, Baumbach, Jan, Kacprowski, Tim, List, Markus
Publicado 2022

Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism

por Maschietto, Federica, Qiu, Tianyin, Wang, Jimin, Shi, Yuanjun, Allen, Brandon, Lisi, George P., Lolis, Elias, Batista, Victor S.
Publicado 2023

A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers

por Yang, Ming-Ren, Wu, Yu-Wei
Publicado 2022

Dual guide RNA-mediated concurrent C&G-to-T&A and A&T-to-G&C conversions using CRISPR base editors

por Zhao, Yuting, Li, Min, Liu, Jie, Xue, Xiaowen, Zhong, Jingli, Lin, Jianxiang, Ye, Bo, Chen, Jun, Qiao, Yunbo
Publicado 2023

CUCUME: An RNA methylation database integrating systemic mRNAs signals, GWAS and QTL genetic regulation and epigenetics in different tissues of Cucurbitaceae

por Li, Xiaojun, Lin, Shujin, Xiang, Chenggang, Liu, Wenqian, Zhang, Xiaojing, Wang, Cuicui, Lu, Xiaohong, Liu, Mengshuang, Wang, Tao, Liu, Zixi, Wang, Naonao, Gao, Lihong, Han, Xiao, Zhang, Wenna
Publicado 2023

Molecular epidemiology and genomic insights into the transmission of carbapenem-resistant NDM-producing Escherichia coli

por Xu, Juan, Guo, Hao, Li, Lirong, He, Fang
Publicado 2023