Nucleobindin-2 consists of two structural components: The Zn(2+)-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca(2+)-sensitive C-terminal half, consisting of...

por Bystranowska, Dominika, Skorupska, Anna, Sołtys, Katarzyna, Padjasek, Michał, Krężel, Artur, Żak, Andrzej, Kaus-Drobek, Magdalena, Taube, Michał, Kozak, Maciej, Ożyhar, Andrzej
Publicado 2021

PathExNET: A tool for extracting pathway expression networks from gene expression statistics

por Minadakis, George, Muñoz-Pomer Fuentes, Alfonso, Tsouloupas, George, Papatheodorou, Irene, Spyrou, George M.
Publicado 2021

Disentangling the abundance and structure of Vibrio communities in a semi-enclosed Bay with mariculture (Dongshan Bay, Southern China)

por Xu, Wei, Lin, Wenzhen, Wang, Zhichao, Gao, Yuanhao, Luo, Yu, Grossart, Hans-Peter, Guo, Ying, Gao, Qiancheng, Huang, Lixing, Luo, Zhuhua
Publicado 2021

Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors

por Gallego-Yerga, Laura, Ochoa, Rodrigo, Lans, Isaías, Peña-Varas, Carlos, Alegría-Arcos, Melissa, Cossio, Pilar, Ramírez, David, Peláez, Rafael
Publicado 2021

A primer on machine learning techniques for genomic applications

por Monaco, Alfonso, Pantaleo, Ester, Amoroso, Nicola, Lacalamita, Antonio, Lo Giudice, Claudio, Fonzino, Adriano, Fosso, Bruno, Picardi, Ernesto, Tangaro, Sabina, Pesole, Graziano, Bellotti, Roberto
Publicado 2021

MetaCancer: A deep learning-based pan-cancer metastasis prediction model developed using multi-omics data

por Albaradei, Somayah, Napolitano, Francesco, Thafar, Maha A., Gojobori, Takashi, Essack, Magbubah, Gao, Xin
Publicado 2021

Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

por Fedrizzi, Tarcisio, Ciani, Yari, Lorenzin, Francesca, Cantore, Thomas, Gasperini, Paola, Demichelis, Francesca
Publicado 2021

Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery

por Wang, Zhonglei, Yang, Liyan, Zhao, Xian-En
Publicado 2021

Docking-generated multiple ligand poses for bootstrapping bioactivity classifying Machine Learning: Repurposing covalent inhibitors for COVID-19-related TMPRSS2 as case study

por Hatmal, Ma'mon M., Abuyaman, Omar, Taha, Mutasem
Publicado 2021

Shared properties and singularities of exoribonuclease-resistant RNAs in viruses

por Vicens, Quentin, Kieft, Jeffrey S.
Publicado 2021

Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome

por Dong, Qi, Liu, Mingyue, Chen, Bo, Zhao, Zhangxiang, Chen, Tingting, Wang, Chengyu, Zhuang, Shuping, Li, Yawei, Wang, Yuquan, Ai, Liqiang, Liu, Yaoyao, Liang, Haihai, Qi, Lishuang, Gu, Yunyan
Publicado 2021

Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders

por Ajjugal, Yogeeshwar, Rathinavelan, Thenmalarchelvi
Publicado 2021

Mechanistic and thermodynamic characterization of oxathiazolones as potent and selective covalent immunoproteasome inhibitors

por Mihalovits, Levente M., Ferenczy, György G., Keserű, György M.
Publicado 2021

Identification of subtypes correlated with tumor immunity and immunotherapy in cutaneous melanoma

por Liu, Qian, Nie, Rongfang, Li, Mengyuan, Li, Lin, Zhou, Haiying, Lu, Hui, Wang, Xiaosheng
Publicado 2021

ARMT: An automatic RNA-seq data mining tool based on comprehensive and integrative analysis in cancer research

por Huang, Guanda, Zhang, Haibo, Qu, Yimo, Huang, Kaitang, Gong, Xiaocheng, Wei, Jinfen, Du, Hongli
Publicado 2021

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

por Rendulić, Toni, Alves, João, Azevedo-Silva, João, Soares-Silva, Isabel, Casal, Margarida
Publicado 2021

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation

por Remya, Chandran, Dileep, K.V., Koti Reddy, Eeda, Mantosh, Kumar, Lakshmi, Kesavan, Sarah Jacob, Reena, Sajith, Ayyiliyath M., Jayadevi Variyar, E., Anwar, Shaik, Zhang, Kam Y.J., Sadasivan, C., Omkumar, R.V.
Publicado 2021

An overview of potential inhibitors targeting non-structural proteins 3 (PL(pro) and Mac1) and 5 (3CL(pro)/M(pro)) of SARS-CoV-2

por Yan, Fangfang, Gao, Feng
Publicado 2021

Advances in flux balance analysis by integrating machine learning and mechanism-based models

por Sahu, Ankur, Blätke, Mary-Ann, Szymański, Jędrzej Jakub, Töpfer, Nadine
Publicado 2021

TS-m6A-DL: Tissue-specific identification of N6-methyladenosine sites using a universal deep learning model

por Abbas, Zeeshan, Tayara, Hilal, Zou, Quan, Chong, Kil To
Publicado 2021