Multi-omics landscape and clinical significance of a SMAD4-driven immune signature: Implications for risk stratification and frontline therapies in pancreatic cancer

por Wang, Libo, Liu, Zaoqu, Zhu, Rongtao, Liang, Ruopeng, Wang, Weijie, Li, Jian, Zhang, Yuyuan, Guo, Chunguang, Han, Xinwei, Sun, Yuling
Publicado 2022

MPEPE, a predictive approach to improve protein expression in E. coli based on deep learning

por Ding, Zundan, Guan, Feifei, Xu, Guoshun, Wang, Yuchen, Yan, Yaru, Zhang, Wei, Wu, Ningfeng, Yao, Bin, Huang, Huoqing, Tuller, Tamir, Tian, Jian
Publicado 2022

BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure

por Konanov, Dmitry N., Krivonos, Danil V., Ilina, Elena N., Babenko, Vladislav V.
Publicado 2022

Corrigendum to: “Farnesoid X receptor (FXR): Structures and ligands” [Comput. Struct. Biotechnol. J. 19 (2021) 2148–2159]

por Jiang, Longying, Zhang, Huajun, Xiao, Desheng, Wei, Hudie, Chen, Yongheng
Publicado 2022

SNP discovery and structural insights into OeFAD2 unravelling high oleic/linoleic ratio in olive oil

por Ben Ayed, Rayda, Moreau, Fabienne, Ben Hlima, Hajer, Rebai, Ahmed, Ercisli, Sezai, Kadoo, Narendra, Hanana, Mohsen, Assouguem, Amine, Ullah, Riaz, Ali, Essam A.
Publicado 2022

Msuite2: All-in-one DNA methylation data analysis toolkit with enhanced usability and performance

por Li, Lishi, An, Yunyun, Ma, Li, Yang, Mengqi, Yuan, Pengxiang, Liu, Xiaojian, Jin, Xin, Zhao, Yu, Zhang, Songfa, Hong, Xin, Sun, Kun
Publicado 2022

Multi-label classification for multi-drug resistance prediction of Escherichia coli

por Ren, Yunxiao, Chakraborty, Trinad, Doijad, Swapnil, Falgenhauer, Linda, Falgenhauer, Jane, Goesmann, Alexander, Schwengers, Oliver, Heider, Dominik
Publicado 2022

Inhibition of the main protease of SARS-CoV-2 (M(pro)) by repurposing/designing drug-like substances and utilizing nature’s toolbox of bioactive compounds

por Antonopoulou, Io, Sapountzaki, Eleftheria, Rova, Ulrika, Christakopoulos, Paul
Publicado 2022

OmicsView: Omics data analysis through interactive visual analytics

por Casey, Fergal, Negi, Soumya, Zhu, Jing, Sun, Yu H., Zavodszky, Maria, Cheng, Derrick, Lin, Dongdong, John, Sally, Penny, Michelle A., Sexton, David, Zhang, Baohong
Publicado 2022

Comprehensive characterization of human–virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs

por Li, Si, Zhou, Weiwei, Li, Donghao, Pan, Tao, Guo, Jing, Zou, Haozhe, Tian, Zhanyu, Li, Kongning, Xu, Juan, Li, Xia, Li, Yongsheng
Publicado 2022

Deep learning in prediction of intrinsic disorder in proteins

por Zhao, Bi, Kurgan, Lukasz
Publicado 2022

Both simulation and sequencing data reveal coinfections with multiple SARS-CoV-2 variants in the COVID-19 pandemic

por Li, Yinhu, Jiang, Yiqi, Li, Zhengtu, Yu, Yonghan, Chen, Jiaxing, Jia, Wenlong, Kaow Ng, Yen, Ye, Feng, Cheng Li, Shuai, Shen, Bairong
Publicado 2022

KDmarkers: A biomarker database for investigating epigenetic methylation and gene expression levels in Kawasaki disease

por Wu, Wei-Sheng, Yang, Tzu-Hsien, Chen, Kuang-Den, Lin, Po-Heng, Chen, Guan-Ru, Kuo, Ho-Chang
Publicado 2022

INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine

por Li, Xianhai, Tang, Qiang, Meng, Fanbo, Du, Pufeng, Chen, Wei
Publicado 2022

Elucidation of the conformational dynamics and assembly of Argonaute–RNA complexes by distinct yet coordinated actions of the supplementary microRNA

por Zhuang, Haiming, Fan, Xiaohua, Ji, Dong, Wang, Yuanhao, Fan, Jigang, Li, Mingyu, Ni, Duan, Lu, Shaoyong, Li, Xiaolong, Chai, Zongtao
Publicado 2022

Understanding desaturation/hydroxylation activity of castor stearoyl Δ(9)-Desaturase through rational mutagenesis

por Tupec, Michal, Culka, Martin, Machara, Aleš, Macháček, Stanislav, Bím, Daniel, Svatoš, Aleš, Rulíšek, Lubomír, Pichová, Iva
Publicado 2022

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

por Nikitin, Dmitri, Mican, Jan, Toul, Martin, Bednar, David, Peskova, Michaela, Kittova, Patricia, Thalerova, Sandra, Vitecek, Jan, Damborsky, Jiri, Mikulik, Robert, Fleishman, Sarel J., Prokop, Zbynek, Marek, Martin
Publicado 2022

Nextcast: A software suite to analyse and model toxicogenomics data

por Serra, Angela, Saarimäki, Laura Aliisa, Pavel, Alisa, del Giudice, Giusy, Fratello, Michele, Cattelani, Luca, Federico, Antonio, Laurino, Omar, Marwah, Veer Singh, Fortino, Vittorio, Scala, Giovanni, Sofia Kinaret, Pia Anneli, Greco, Dario
Publicado 2022

The impact of noise and missing fragmentation cleavages on de novo peptide identification algorithms

por McDonnell, Kevin, Howley, Enda, Abram, Florence
Publicado 2022

Investigation of the pH-dependent aggregation mechanisms of GCSF using low resolution protein characterization techniques and advanced molecular dynamics simulations

por Ko, Suk Kyu, Berner, Carolin, Kulakova, Alina, Schneider, Markus, Antes, Iris, Winter, Gerhard, Harris, Pernille, Peters, Günther H.J.
Publicado 2022