Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance

por He, Feng, Huang, Yanrui, Song, Zhi, Zhou, Huanjiao Jenny, Zhang, Haifeng, Perry, Rachel J., Shulman, Gerald I., Min, Wang
Publicado 2020

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

por Apelt, Katja, White, Susan M., Kim, Hyun Suk, Yeo, Jung-Eun, Kragten, Angela, Wondergem, Annelotte P., Rooimans, Martin A., González-Prieto, Román, Wiegant, Wouter W., Lunke, Sebastian, Flanagan, Daniel, Pantaleo, Sarah, Quinlan, Catherine, Hardikar, Winita, van Attikum, Haico, Vertegaal, Alfred C.O., Wilson, Brian T., Wolthuis, Rob M.F., Schärer, Orlando D., Luijsterburg, Martijn S.
Publicado 2020

Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts

por Hanft, Laurin M., Fitzsimons, Daniel P., Hacker, Timothy A., Moss, Richard L., McDonald, Kerry S.
Publicado 2021

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

por Le Bert, Nina, Clapham, Hannah E., Tan, Anthony T., Chia, Wan Ni, Tham, Christine Y.L., Lim, Jane M., Kunasegaran, Kamini, Tan, Linda Wei Lin, Dutertre, Charles-Antoine, Shankar, Nivedita, Lim, Joey M.E., Sun, Louisa Jin, Zahari, Marina, Tun, Zaw Myo, Kumar, Vishakha, Lim, Beng Lee, Lim, Siew Hoon, Chia, Adeline, Tan, Yee-Joo, Tambyah, Paul Anantharajah, Kalimuddin, Shirin, Lye, David, Low, Jenny G.H., Wang, Lin-Fa, Wan, Wei Yee, Hsu, Li Yang, Bertoletti, Antonio, Tam, Clarence C.
Publicado 2021

Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways

por Martinez-Espinosa, Pedro L., Neely, Alan, Ding, Jiuping, Lingle, Christopher J.
Publicado 2021

RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

por Fic, Weronika, Bastock, Rebecca, Raimondi, Francesco, Los, Erinn, Inoue, Yoshiko, Gallop, Jennifer L., Russell, Robert B., St Johnston, Daniel
Publicado 2021

A mouse model of Huntington’s disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers

por Romer, Shannon H., Metzger, Sabrina, Peraza, Kristiana, Wright, Matthew C., Jobe, D. Scott, Song, Long-Sheng, Rich, Mark M., Foy, Brent D., Talmadge, Robert J., Voss, Andrew A.
Publicado 2021

Phase separation of Axin organizes the β-catenin destruction complex

por Nong, Junxiu, Kang, Kexin, Shi, Qiaoni, Zhu, Xuechen, Tao, Qinghua, Chen, Ye-Guang
Publicado 2021

Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

por Rynearson, Kevin D., Ponnusamy, Moorthi, Prikhodko, Olga, Xie, Yuhuan, Zhang, Can, Nguyen, Phuong, Hug, Brenda, Sawa, Mariko, Becker, Ann, Spencer, Brian, Florio, Jazmin, Mante, Michael, Salehi, Bahar, Arias, Carlos, Galasko, Douglas, Head, Brian P., Johnson, Graham, Lin, Jiunn H., Duddy, Steven K., Rissman, Robert A., Mobley, William C., Thinakaran, Gopal, Tanzi, Rudolph E., Wagner, Steven L.
Publicado 2021

Type V myosin focuses the polarisome and shapes the tip of yeast cells

por Dünkler, Alexander, Leda, Marcin, Kromer, Jan-Michael, Neller, Joachim, Gronemeyer, Thomas, Goryachev, Andrew B., Johnsson, Nils
Publicado 2021

Immunodominant antibody germlines in COVID-19

por Andreano, Emanuele, Rappuoli, Rino
Publicado 2021

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

por Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate, Vetter, Irina
Publicado 2021

DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs

por Fechner, Sylvia, D’Alessandro, Isabel, Wang, Lingxin, Tower, Calvin, Tao, Li, Goodman, Miriam B.
Publicado 2021

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

por Lucca, Liliana E., Axisa, Pierre-Paul, Lu, Benjamin, Harnett, Brian, Jessel, Shlomit, Zhang, Le, Raddassi, Khadir, Zhang, Lin, Olino, Kelly, Clune, James, Singer, Meromit, Kluger, Harriet M., Hafler, David A.
Publicado 2021

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

por Pauken, Kristen E., Shahid, Osmaan, Lagattuta, Kaitlyn A., Mahuron, Kelly M., Luber, Jacob M., Lowe, Margaret M., Huang, Linglin, Delaney, Conor, Long, Jaclyn M., Fung, Megan E., Newcomer, Kathleen, Tsai, Katy K., Chow, Melissa, Guinn, Samantha, Kuchroo, Juhi R., Burke, Kelly P., Schenkel, Jason M., Rosenblum, Michael D., Daud, Adil I., Sharpe, Arlene H., Singer, Meromit
Publicado 2021

Microtubule nucleation without a ring?

por Merdes, Andreas
Publicado 2021

Correction: An early endosome–derived retrograde trafficking pathway promotes secretory granule maturation

por Ma, Cheng-I J., Yang, Yitong, Kim, Taeah, Chen, Chang Hua, Polevoy, Gordon, VIssa, Miluska, Burgess, Jason, Brill, Julie A.
Publicado 2021

The taming of a scramblase

por Whitlock, Jarred M.
Publicado 2021

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

por Woo, Marcel S., Ufer, Friederike, Rothammer, Nicola, Di Liberto, Giovanni, Binkle, Lars, Haferkamp, Undine, Sonner, Jana K., Engler, Jan Broder, Hornig, Sönke, Bauer, Simone, Wagner, Ingrid, Egervari, Kristof, Raber, Jacob, Duvoisin, Robert M., Pless, Ole, Merkler, Doron, Friese, Manuel A.
Publicado 2021

Multimeric antibodies from antigen-specific human IgM(+) memory B cells restrict Plasmodium parasites

por Thouvenel, Christopher D., Fontana, Mary F., Netland, Jason, Krishnamurty, Akshay T., Takehara, Kennidy K., Chen, Yu, Singh, Suruchi, Miura, Kazutoyo, Keitany, Gladys J., Lynch, Eric M., Portugal, Silvia, Miranda, Marcos C., King, Neil P., Kollman, Justin M., Crompton, Peter D., Long, Carole A., Pancera, Marie, Rawlings, David J., Pepper, Marion
Publicado 2021