Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) activity is required for V(D)J recombination

por Chen, Chun-Chin, Chen, Bo-Ruei, Wang, Yinan, Curman, Philip, Beilinson, Helen A., Brecht, Ryan M., Liu, Catherine C., Farrell, Ryan J., de Juan-Sanz, Jaime, Charbonnier, Louis-Marie, Kajimura, Shingo, Ryan, Timothy A., Schatz, David G., Chatila, Talal A., Wikstrom, Jakob D., Tyler, Jessica K., Sleckman, Barry P.
Publicado 2021

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

por Proks, Peter, Schewe, Marcus, Conrad, Linus J., Rao, Shanlin, Rathje, Kristin, Rödström, Karin E.J., Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Publicado 2021

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

por Ho, Theodore T., Dellorusso, Paul V., Verovskaya, Evgenia V., Bakker, Sietske T., Flach, Johanna, Smith, Lucas K., Ventura, Patrick B., Lansinger, Olivia M., Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A., Villeda, Saul A., Passegué, Emmanuelle
Publicado 2021

Mechanism of p38 MAPK–induced EGFR endocytosis and its crosstalk with ligand-induced pathways

por Perez Verdaguer, Mireia, Zhang, Tian, Paulo, Joao A., Gygi, Steven, Watkins, Simon C., Sakurai, Hiroaki, Sorkin, Alexander
Publicado 2021

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

por Milner, J. Justin, Toma, Clara, Quon, Sara, Omilusik, Kyla, Scharping, Nicole E., Dey, Anup, Reina-Campos, Miguel, Nguyen, Hongtuyet, Getzler, Adam J., Diao, Huitian, Yu, Bingfei, Delpoux, Arnaud, Yoshida, Tomomi M., Li, Deyao, Qi, Jun, Vincek, Adam, Hedrick, Stephen M., Egawa, Takeshi, Zhou, Ming-Ming, Crotty, Shane, Ozato, Keiko, Pipkin, Matthew E., Goldrath, Ananda W.
Publicado 2021

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies

por Heindl, Steffanie, Ricci, Alessio, Carofiglio, Olga, Zhou, Qihui, Arzberger, Thomas, Lenart, Nikolett, Franzmeier, Nicolai, Hortobagyi, Tibor, Nelson, Peter T., Stowe, Ann M., Denes, Adam, Edbauer, Dieter, Liesz, Arthur
Publicado 2021

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

por Leon, Kelly E., Buj, Raquel, Lesko, Elizabeth, Dahl, Erika S., Chen, Chi-Wei, Tangudu, Naveen Kumar, Imamura-Kawasawa, Yuka, Kossenkov, Andrew V., Hobbs, Ryan P., Aird, Katherine M.
Publicado 2021

LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components

por Fan, Yilin, Köberlin, Marielle S., Ratnayeke, Nalin, Liu, Chad, Deshpande, Madhura, Gerhardt, Jeannine, Meyer, Tobias
Publicado 2021

SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components

por Abudu, Yakubu Princely, Shrestha, Birendra Kumar, Zhang, Wenxin, Palara, Anthimi, Brenne, Hanne Britt, Larsen, Kenneth Bowitz, Wolfson, Deanna Lynn, Dumitriu, Gianina, Øie, Cristina Ionica, Ahluwalia, Balpreet Singh, Levy, Gahl, Behrends, Christian, Tooze, Sharon A., Mouilleron, Stephane, Lamark, Trond, Johansen, Terje
Publicado 2021

Taking regulatory T cells into medicine

por Sakaguchi, Shimon
Publicado 2021

The discovery of dendritic cells

por Moberg, Carol L.
Publicado 2021

Sterilizing immunity: New opportunities for rational TB vaccine design

por Sher, Alan, Flynn, Joanne L.
Publicado 2021

Autoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects

por Tovey, Corinne A., Tsuji, Chisato, Egerton, Alice, Bernard, Fred, Guichet, Antoine, de la Roche, Marc, Conduit, Paul T.
Publicado 2021

Cell influx and contractile actomyosin force drive mammary bud growth and invagination

por Trela, Ewelina, Lan, Qiang, Myllymäki, Satu-Marja, Villeneuve, Clémentine, Lindström, Riitta, Kumar, Vinod, Wickström, Sara A., Mikkola, Marja L.
Publicado 2021

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1

por Rook, Matthew L., Miaro, Megan, Couch, Tyler, Kneisley, Dana L., Musgaard, Maria, MacLean, David M.
Publicado 2021

Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage

por Houseright, Ruth A., Miskolci, Veronika, Mulvaney, Oscar, Bortnov, Valeriu, Mosher, Deane F., Rindy, Julie, Bennin, David A., Huttenlocher, Anna
Publicado 2021

ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation

por Yang, Xi, Reist, Lucas, Chomchai, Dominic A., Chen, Liang, Arines, Felichi Mae, Li, Ming
Publicado 2021

Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins

por Pitsidianaki, Ioanna, Morgan, Jason, Adams, Jamie, Campbell, Kyra
Publicado 2021

The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma

por Verma, Mukesh, Michalec, Lidia, Sripada, Anand, McKay, Jerome, Sirohi, Kapil, Verma, Divya, Sheth, Dipa, Martin, Richard, Dyjack, Nathan, Seibold, Max A., Knapp, Jennifer R., Tu, Ting-Hui, O’Connor, Brian P., Gorska, Magdalena M., Alam, Rafeul
Publicado 2021

Titin–N2A: More than a signaling node?

por van der Pijl, Robbert J., Ottenheijm, Coen A.C.
Publicado 2021