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321“…Moreover, such approaches tend to be specific to a single class of RNA or DNA modification, and generate only indirect readouts of modification status. …”
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322por Yang, Zhiyuan, Zhang, Siyu, Xia, Tian, Fan, Yue, Shan, Ying, Zhang, Kaiwen, Xiong, Jiayan, Gu, Miao, You, Bo“…RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. …”
Publicado 2022
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323por Sidoli, Simone“…Sidoli will describe how mass spectrometry is applied to investigate combinatorial histone modifications that benchmark regions of decondensed heterochromatin, and show the enrichment of unusual histone modifications in a cohort of centenarian patients.…”
Publicado 2022
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324por Santana, Dalileia Aparecida, Smith, Marilia de Arruda Cardoso, Chen, Elizabeth Suchi“…Since Late-onset Alzheimer’s disease (LOAD) derives from a combination of genetic variants and environmental factors, epigenetic modifications have been predicted to play a role in the etiopathology of LOAD. …”
Publicado 2023
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325
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326“…One of the major challenges in developing a pan-specific method for the selective modification of α-Nme(2) PTM is the competing reaction with dimethyl lysine (Kme(2)) PTM of a similar structure. …”
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327N(6)-Methyladenosine mRNA Modification: From Modification Site Selectivity to Neurological Functions“…[Image: see text] The development of various chemical methods has enabled scientists to decipher the distribution features and biological functions of RNA modifications in the past decade. In addition to modifying noncoding RNAs such as tRNAs and rRNAs, N(6)-methyladenosine (m(6)A) has been proven to be the most abundant internal chemical modification on mRNAs in eukaryotic cells and is also the most widely studied mRNA modification to date. …”
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328por Ong, How Chee, Coimbra, João T. S., Kwek, Germain, Ramos, Maria J., Xing, Bengang, Fernandes, Pedro A., García, Felipe“…These results provide further insights into the thermodynamics of this process and the effect of alkyl and aryl modular modifications.…”
Publicado 2021
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329por Bailey, Andrew D, Talkish, Jason, Ding, Hongxu, Igel, Haller, Duran, Alejandra, Mantripragada, Shreya, Paten, Benedict, Ares, Manuel“…During ribosome biogenesis, modifications are added at various stages of assembly. …”
Publicado 2022
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330por Li, Ganglei, Zhu, Yu, Gu, Jun, Zhang, Tiesong, Wang, Feng, Huang, Kaiyuan, Gu, Chenjie, Xu, Kangli, Zhan, Renya, Shen, Jian“…RNA modifications play a major role in tumorigenicity and progression, but the expression and function in glioblastoma (GBM) have not been well described. …”
Publicado 2022
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331por McPeake, Joanne, Boehm, Leanne, Hibbert, Elizabeth, Hauschildt, Katrina, Bakhru, Rita, Bastin, Anthony, Butcher, Brad, Eaton, Tammy, Harris, Wendy, Hope, Aluko, Jackson, James, Johnson, Annie, Kloos, Janet, Korzick, Karen, McCartney, Judith, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Slack, Andrew, Wade, Dorothy, Still, Mary, Netzer, Giora, Hopkins, Ramona O, Mikkelsen, Mark E, Iwashyna, Theodore, Haines, Kimberley, Sevin, Carla“…We identified SDoH that were modified by critical illness, and the effect of such modifications on recovery from critical illness. DESIGN: In-depth semistructured interviews following hospital discharge. …”
Publicado 2022
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332“…Dysregulated epigenetic enzymes and resultant abnormal epigenetic modifications (EMs) have been suggested to be closely related to tumor occurrence and progression. …”
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334
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335por dos Santos, Luana Pereira, Castro, Jonathan Pena, Francisco, Carine Mendonça, Vicari, Marcelo Ricardo, de Almeida, Mara Cristina, Goll, Leonardo Gusso, Morelli, Sandra, Artoni, Roberto Ferreira“…Chromosome painting with a B chromosome-specific probe yielded signals for several B microchromosomes, with one exhibiting no markings. …”
Publicado 2013
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336“…This study was conducted to investigate and document the use of medicinal plants in the Sedie Muja district. Sixteen key informants were selected purposively and 72 informants were selected randomly from 5 wards. …”
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337“…Spondyloepiphyseal dysplasia (SEDKF) is a rare skeletal dysplasia associated with kyphosis and low bone mineral density, significantly delayed growth, and skeletal deformities. …”
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339“…INTRODUCTION: Occupational therapists recommending home modifications in Australia are often required by funding bodies to consider ‘value’ and ‘value for money’ (VFM); however, clear guidance on how to define and apply these concepts is not always provided. …”
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340“…Various modification treatments have been carried out to improve the physicochemical and functional properties of various types of starch and flour. …”
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