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681“…Posttranslational histone modifications are prime candidates for the regulation of the chromatin structure. …”
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682por Terwilliger, Thomas C.“…Statistical density modification is a technique for phase improvement through a calculation of the posterior probability of the phases, given experimental phase information and expectations about features of the electron-density map. …”
Publicado 2002
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683“…The purpose of this review is to focus upon the rationale behind the chemical modifications of several recently marketed AEDs or drugs in development and to categorize them according to the main purposes for the improvements: better efficacy or tolerability accompanied by improved pharmacokinetic properties. …”
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684
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685“…A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. …”
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686“…An emerging field of investigation in the search for treatment of human disease is the modulation of chromatin modifications. Chromatin modifications impart virtually all processes occurring in the mammalian nucleus, from regulation of transcription to genomic stability and nuclear high order organization. …”
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687“…We speculate that these structural modifications in the morphology and microstructure of CNTs might be due to the charge transfer from boron to the graphite matrix, resulting in shortening of the carbon–carbon bonds.…”
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688“…Our data demonstrates that HA acclimatization is associated with brain structural modifications, including the loss of regional cortical grey matter accompanied by changes in the white matter, which may underlie the physiological adaptation of residents at HA.…”
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689“…Proliferative Cell Nuclear Antigen (PCNA), which is an essential component of the fork, undergoes posttranslational modifications, particularly ubiquitylation and sumoylation that are critical for lesion bypass and for filling of DNA gaps which result from this bypass. …”
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690
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691por Cantara, William A., Crain, Pamela F., Rozenski, Jef, McCloskey, James A., Harris, Kimberly A., Zhang, Xiaonong, Vendeix, Franck A. P., Fabris, Daniele, Agris, Paul F.“…Since its inception in 1994, The RNA Modification Database (RNAMDB, http://rna-mdb.cas.albany.edu/RNAmods/) has served as a focal point for information pertaining to naturally occurring RNA modifications. …”
Publicado 2011
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692por Takahashi, Noriko, Ohashi, Seishi, Sadykov, Marat R., Mizutani-Ui, Yoko, Kobayashi, Ichizo“…Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. …”
Publicado 2011
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693“…Taken together, these results show that vascular smooth muscle cells take up and utilize NE for the modification of proteins, and that this modification may play an important role in vascular contraction.…”
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694“…Density modification often suffers from an overestimation of phase quality, as seen by escalated figures of merit. …”
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695por Chouchani, Edward T, James, Andrew M, Fearnley, Ian M, Lilley, Kathryn S, Murphy, Michael P“…Although there is considerable evidence for a functional role for cysteine modifications, the identity and physiological significance of most protein thiol alterations are unknown. …”
Publicado 2011
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696“…Attachment of a myristoyl group to NH(2)-terminus of a nascent protein among protein post-translational modification (PTM) is called myristoylation. The myristate moiety of proteins plays an important role for their biological functions, such as regulation of membrane binding (HIV-1 Gag) and enzyme activity (AMPK). …”
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697“…Histone post-translational modifications (PTMs) positively and negatively regulate gene expression, and are consequently a vital influence on the genomic profile of all eukaryotic species. …”
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698por Erler, Alexandre“…One objection to enhancement technologies is that they might lead us to live inauthentic lives. Memory modification technologies (MMTs) raise this worry in a particularly acute manner. …”
Publicado 2010
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699por Zhu, Xuefeng, Zhang, Yongqiang, Bjornsdottir, Gudrun, Liu, Zhongle, Quan, Amy, Costanzo, Michael, Dávila López, Marcela, Westholm, Jakub Orzechowski, Ronne, Hans, Boone, Charles, Gustafsson, Claes M., Myers, Lawrence C.“…These binding assays also showed Mediator—histone H4 peptide interactions are specifically inhibited by acetylation of the histone H4 lysine 16, a residue critical in transcriptional silencing. …”
Publicado 2011
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