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721
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722“…This review provides an overview of critical epigenetic processes shaping pathology and pain, highlights current research support for the role of epigenomic modification in the development of chronic pain, and summarizes the therapeutic potential to alter epigenetic processes to improve health outcomes.…”
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723“…The aim of this study was to investigate the sulfated modification of laminarin and the changes in structure and antitumor activity. …”
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724por Nic-Can, Geovanny, Hernández-Castellano, Sara, Kú-González, Angela, Loyola-Vargas, Víctor M, De-la-Peña, Clelia“…CONCLUSIONS: There are many protocols to study chromatin modifications; however, most of them are expensive, difficult and require sophisticated equipment. …”
Publicado 2013
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725“…The rgl genes were renamed mcrA and mcrBC (modified cytosine restriction). The new class of modification-dependent restriction enzymes was named Type IV, as distinct from the familiar modification-blocked Types I–III. …”
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726
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727por Brosseau, Jean-Philippe, Lucier, Jean-François, Nwilati, Hanad, Thibault, Philippe, Garneau, Daniel, Gendron, Daniel, Durand, Mathieu, Couture, Sonia, Lapointe, Elvy, Prinos, Panagiotis, Klinck, Roscoe, Perreault, Jean-Pierre, Chabot, Benoit, Abou-Elela, Sherif“…Pre-mRNA alternative splicing is modified in cancer, but the origin and specificity of these changes remain unclear. Here, we probed ovarian tumors to identify cancer-associated splicing isoforms and define the mechanism by which splicing is modified in cancer cells. …”
Publicado 2014
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728por Liu, Zexian, Wang, Yongbo, Gao, Tianshun, Pan, Zhicheng, Cheng, Han, Yang, Qing, Cheng, Zhongyi, Guo, Anyuan, Ren, Jian, Xue, Yu“…We reported an integrated database of Compendium of Protein Lysine Modifications (CPLM; http://cplm.biocuckoo.org) for protein lysine modifications (PLMs), which occur at active ε-amino groups of specific lysine residues in proteins and are critical for orchestrating various biological processes. …”
Publicado 2014
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729por Shao, Changwei, Li, Qiye, Chen, Songlin, Zhang, Pei, Lian, Jinmin, Hu, Qiaomu, Sun, Bing, Jin, Lijun, Liu, Shanshan, Wang, Zongji, Zhao, Hongmei, Jin, Zonghui, Liang, Zhuo, Li, Yangzhen, Zheng, Qiumei, Zhang, Yong, Wang, Jun, Zhang, Guojie“…In contrast, female-specific W chromosomal genes are suppressed in pseudomales by methylation regulation. …”
Publicado 2014
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730por Shigi, Naoki“…Many sulfur-carrier proteins are responsible for delivering this activated sulfur to each biosynthesis pathway. Finally, specific “modification enzymes” activate target tRNAs and then incorporate sulfur atoms. …”
Publicado 2014
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731“…It is widely accepted that transcriptional regulation of eukaryotic genes is intimately coupled to covalent modifications of the underlying chromatin template, and in certain cases the functional consequences of these modifications have been characterized. …”
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732
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733“…Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. …”
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734
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735por Riquier, Sylvie, Breton, Jacques, Abbas, Kahina, Cornu, David, Bouton, Cécile, Drapier, Jean-Claude“…We investigated the respective modifications induced by H(2)O(2), NO and H(2)S in the murine macrophage cell line RAW264.7 by mass spectrometry and immunoblotting after separating 2-Cys Prxs by one-dimensional or two-dimensional PAGE. …”
Publicado 2014
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736“…As well as inducing the production of proteins, including chemokines, oxidative stress can alter proteins themselves, both directly and by induction of enzymes capable of modification. These alterations can lead to important modifications to their biological activity and also alter detection by some antibodies, potentially limiting the biological relevance of some immunochemical and proteomic biomarkers. …”
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737
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738por Goldfarb, AdamEnlace del recurso
Publicado 2014
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739por Aizawa, Tetsushi, Togashi, Shinji, Domoto, Takashi, Sasaki, Kaoru, Kiyosawa, Tomoharu, Sekido, MitsuruEnlace del recurso
Publicado 2014
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740“…The ability of the virion to serve as a platform for a variety of applications heavily relies on the functionalization of the phage coat proteins with a wide variety of functionalities. Genetic modification of the coat proteins has been the most widely used strategy for functionalizing the virion; however, complementary chemical modification strategies can help to diversify the range of materials that can be developed. …”
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