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901“…Based on their prominent stability, cargo-carriage properties, stable circulating capability, and favorable safety profile, exosomes have great potential to regulate cellular communication by carrying variable cargoes into specific site. However, the specific loading strategies and modification methods for engineered exosomes to enhance the targeting ability are unclear. …”
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902por Sanches, Bruno Domingos Azevedo, Tamarindo, Guilherme Henrique, dos Santos Maldarine, Juliana, da Silva, Alana Della Torre, dos Santos, Vitória Alário, Lima, Maria Letícia Duarte, Rahal, Paula, Góes, Rejane Maira, Taboga, Sebastião Roberto, Felisbino, Sérgio Luis, Carvalho, Hernandes F.Enlace del recurso
Publicado 2020
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903por Li, Zhongwei, Li, Minle, Wang, Diandian, Hou, Pingfu, Chen, Xintian, Chu, Sufang, Chai, Dafei, Zheng, Junnian, Bai, Jin“…Post-translational modifications (PTMs) are important biological events in cancer progression. …”
Publicado 2020
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904“…Moreover, results gathered during recent years indicate that other post-translational modifications (PTMs), namely phosphorylation, SUMOylation and glycosylation, modulate DELLA function. …”
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905por Ashfaq, Aiysha, Clochard, Marie-Claude, Coqueret, Xavier, Dispenza, Clelia, Driscoll, Mark S., Ulański, Piotr, Al-Sheikhly, Mohamad“…The modification of polymers through RIG is durable as it covalently bonds the functional monomers. …”
Publicado 2020
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906por Fujimura, Atsushi, Pei, Hailong, Zhang, Hongquan, Sladitschek, Hanna Lucie, Chang, LeiEnlace del recurso
Publicado 2021
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907por Aguilar Troyano, Francisco José, Merkens, Kay, Anwar, Khadijah, Gómez‐Suárez, Adrián“…Recently, with the development of milder and more versatile radical‐based procedures, the use of strategies relying on radical chemistry for the synthesis and modification of AAs has gained increased attention, as they allow rapid access to libraries of novel unnatural AAs containing a wide range of structural motifs. …”
Publicado 2020
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908“…This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties. Furthermore, the subsequent coupling of biomolecules onto functionalized nanodiamonds is reviewed. …”
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909por Yakovlev, Grigory, Vít, Černý, Polyanskikh, Irina, Gordina, Anastasiya, Pudov, Igor, Gumenyuk, Alexander, Smirnova, Olga“…The nature of changes in the microstructure were studied to determine the influence of complex modifications that showed significant changes in the morphology of the hydration products. …”
Publicado 2021
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910por Naowarojna, Nathchar, Cheng, Ronghai, Lopez, Juan, Wong, Christina, Qiao, Lu, Liu, Pinghua“…Protein chemical modifications are important tools for elucidating chemical and biological functions of proteins. …”
Publicado 2021
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911por Badura, Jennifer, van Wyk, Niël, Brezina, Silvia, Pretorius, Isak S., Rauhut, Doris, Wendland, Jürgen, von Wallbrunn, Christian“…This study marks the first steps in the development of gene modification tools and paves the road for functional gene analyses of this yeast.…”
Publicado 2021
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912“…The effect and function of Smurfs depend on PTMs and regulate biological processes. Specifically, these modifications regulate the functional expression of Smurfs by affecting protein degradation and protein interactions. …”
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913por Yagi-Utsumi, Maho, Tanaka, Tomohiro, Otsubo, Yoko, Yamashita, Akira, Yoshimura, Shinji, Nishida, Motohiro, Kato, Koichi“…Interestingly, this modification occurred when Aβ was dissolved into a pre-irradiated buffer, indicating that some reactive species oxidize the Met residue. …”
Publicado 2021
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914por Sun, Jiaxing, Tai, Shi, Tang, Liang, Yang, Hui, Chen, Mingxian, Xiao, Yichao, Li, Xuping, Zhu, Zhaowei, Zhou, Shenghua“…We conclude that the occurrence of acetylation modification during autophagy is a fundamental mechanism underlying autophagy regulation and provides promising targets to retard vascular aging.…”
Publicado 2021
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915“…The current study reuses the MS/MS spectra obtained, for the global discovery of post-translational modifications (PTMs) in this species without specific enrichment methods. …”
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916“…An unmet need is cure or disease modification. This review discusses possible reasons for negative clinical study outcomes on disease modification following promising positive findings from experimental research. …”
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917“…Histone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters. …”
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918por Karbach, Mareike, Zöller, Claudia, Zöller, Georg, Wehrbein, Heinrich, Erbe, Christina“…Inclusion criteria were orthodontic treatment with the Herbst appliance and its modifications. The type of modification, number and frequency of the different modifications were determined on the basis of patient files, X-ray documents, photos and models. …”
Publicado 2021
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919por Hornschuh, M., Wirthgen, E., Wolfien, M., Singh, K. P., Wolkenhauer, O., Däbritz, J.“…In particular, we enable a deeper insight into applied bioanalytical and computational tools, as well as a comprehensive update toward the cell-specific evaluation of DNA methylation and histone modifications.…”
Publicado 2021
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920“…Trends in the dynamically developing application of biocatalysis for the synthesis and modification of polymers over the past 5 years are considered, with an emphasis on the production of biodegradable, biocompatible and functional polymeric materials oriented to medical applications. …”
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