Mostrando 961 - 980 Resultados de 23,460 Para Buscar 'SPDIF~', tiempo de consulta: 1.98s Limitar resultados
  1. 961
    “…With the aging of society, the long-term care insurance system -which includes home modifications to continue living at home- was established in 2000. …”
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  2. 962
    “…In this manuscript we describe how to quantify the severity of coronary calcium, review the armamentarium of contemporary devices available for calcium modification, and provide a systematic approach to device selection, assessment of successful calcium modification, and stent optimization.…”
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  3. 963
    “…Although our understanding about the characteristics and function of arthropod venoms has been evolving in the last decades, a major aspect crucial for the function of these proteins remains poorly studied, the posttranslational modifications (PTMs). Comprehension of such modifications can contribute to better understanding the basis of envenomation, leading to improvements in the specificities of potential therapeutic toxins. …”
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  4. 964
    “…Posttranslational modifications are chemical modifications which can control protein biology. …”
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  5. 965
    “…The concept of modifying the surface electronic properties of an electrocatalyst via stable polymer modification offers an additional route to tune multipathway reactions in polymer/electrocatalyst environments, like with ionomer-modified catalysts or with membrane electrode assemblies.…”
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  6. 966
    “…Accumulating evidence indicates that lamins are functionally regulated by post-translational modifications (PTMs) including farnesylation, phosphorylation, acetylation, SUMOylation, methylation, ubiquitination, and O-GlcNAcylation that affect protein stabilization and the association with chromatin or associated proteins. …”
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  7. 967
  8. 968
  9. 969
    “…The modulation of the function and expression of epigenetic regulators of RNA modification has gradually become the hotspot of cancer research. …”
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  10. 970
    “…Mapping the precise identity, location, and abundance of modified ribonucleotides remains a key goal of many studies aimed at characterizing the function and importance of a given modification. While mapping of specific RNA modifications through short-read sequencing approaches has powered a wealth of new discoveries in the past decade, this approach is limited by inherent biases and an absence of linkage information. …”
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  11. 971
    por Sun, Linchong, Zhang, Huafeng, Gao, Ping
    Publicado 2021
    “…We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolism- and epigenetic modification-based therapeutic prospects in cancer. …”
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  12. 972
    “…Neurogenesis is a sophisticated and complex process by which neural stem cells differentiate into specialized brain cell types at specific times and regions of the brain. A growing body of evidence suggests that epigenetic mechanisms, such as histone modifications, allow the fine-tuning and coordination of spatiotemporal gene expressions during neurogenesis. …”
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  13. 973
    por Keijzer, Jordi F., Albada, Bauke
    Publicado 2021
    “…This review focuses on the use of DNA to achieve the desired conversions and levels of accuracy in protein modification by using DNA (i) as a template to help concentrate dilute reactants, (ii) as a guidance system to achieve selectivity by binding specific proteins, and (iii) even as catalytic entity or construct to enhance protein modification reactions.…”
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  14. 974
    “…Protein modification, also known as PTMs, refers to the chemical modification of specific amino acid residues after protein biosynthesis, which is a key process that can influence the activity or expression level of proteins. …”
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  15. 975
    “…This review summarizes the role of epigenetic mechanisms, mainly DNA methylation and histone modifications, in the development of the pancreas, their contribution to the development of diabetes, and the potential employment of epigenetic modulators in diabetes treatment.…”
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  16. 976
    “…RNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expression. …”
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  17. 977
  18. 978
    “…In this review, we summarized the alteration of enzymes related to various modifications, including histone modification, nonhistone modification, DNA methylation, and RNA methylation, and their epigenetic mechanisms during the progression of CRC metastasis. …”
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  19. 979
  20. 980
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