“…Additionally, genome-wide association studies (GWASs) have identified several genes that might be potential risk factors for AD, including clusterin (CLU), complement receptor 1 (CR1), phosphatidylinositol binding clathrin assembly protein (PICALM), and sortilin-related receptor (SORL1). Recent studies have discovered additional novel genes that might be involved in late-onset AD, such as triggering receptor expressed on myeloid cells 2 (TREM2) and cluster of differentiation 33 (CD33). …”
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“…Although the receptor has no intrinsic catalytic activity it interacts with and modulates the function of TrkA, TrkB, and TrkC, as well as sortilin and the Nogo receptor. This provides substantial cellular and molecular diversity for regulation of neuron survival, neurogenesis, immune responses and processes that support neural function. …”
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“…In previous studies, we reported that the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene single nucleotide polymorphisms (SNPs) are associated with the risk of sporadic Alzheimer’s disease (SAD) in the Han Chinese population. …”
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“…The non-ionic surfactants polysorbate 80 (PEG-20 sorbitan monooleate), decyl glucoside, and a polyglyceryl-4 ester blend were applied to stabilize the nanosystems. …”
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“…Processing of PGRN into GRNs is conserved between humans and mice and is modulated by sortilin expression and mediated by cysteine proteases (i.e. cathpesin L). …”
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“…Tween 80, a poly-ethoxylated sorbitan-oleate ester, is therefore routinely included in anaerobic growth media as a source of unsaturated fatty acids (UFAs). …”
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“…Pseudoternary phase diagrams of three oil types including tea seed oil, grape seed oil, and sesame oil, together with polysorbate 85 or the mixture of polysorbate 85 and sorbitan oleate as surfactants, and absolute ethanol as a co-surfactant were constructed to optimize the microemulsion area. …”
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“…In vitro pro-BDNF treatment caused apoptosis in adipocytes differentiated from C3H10T1/2 cells, and siRNA knockdown of sortilin mitigated these effects. Tamoxifen-inducible PDGFRα(+) cell-specific deletion of BDNF (BDNF(Pdgfra )KO) reduced pro-BDNF expression in eWAT, prevented age-associated declines in sympathetic innervation and mitochondrial content in eWAT, and improved insulin sensitivity. …”
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“…The histone deacetylase (HDAC) inhibitor valproic acid (VPA) has been shown to downregulate TrkB and upregulate the p75NTR/sortilin receptor complex. In the present study, we investigated the VPA effect on the expression of the neurotrophin-3 (NT-3) receptor TrkC, a favorable prognostic marker of neuroblastoma. …”
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“…Chemical crosslinking of bovine serum albumin (BSA) with N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC) in a water-in-oil emulsion with isoparaffinic oil as the continuous phase and sorbitan monooleate as surfactant generates micro-meter-scale spherical particles. …”
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“…The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. …”
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“…In this paper we propose a new framework—MoViLan (Modular Vision and Language) for execution of visually grounded natural language instructions for day to day indoor household tasks. …”
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“…En esta primera fase, se presenta el diseño de la herramienta metodológica para la obtención de los datos, la cual toma como referencia la información contenida en el Sistema de Información Cultural (SIC), Instituto Nacional de Estadística y Geografía (INEGI) y el Registro de Museos Iberoamericanos (RMI), y que servirán como base para la elaboración del registro estatal de museos y, posteriormente, la cartografía respectiva, como parte de las líneas de investigación del Observatorio Universitario de Museos (OUM) en un lapso de dos años.Palabras clave: Museos; Veracruz; Registro Estatal de Museos; metodología; Observatorio Universitario de Museos Abstract This article describes the metho­dology that will be implemented for the diag­nosis of museums in Veracruz. …”
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“…Apicomplexan parasites have a highly polarized morphology, with their apical end containing specific secretory organelles named rhoptries and micronemes, which depend on the unique receptor and transporter sortilin TgSORT for their biogenesis. In the present study, we took advantage of the subcellular polarity of the parasite to engineer a clonal transgenic Toxoplasma line that expresses simultaneously the green fluorescent protein TgSORT-GFP in the post-Golgi-endosome-like compartment and the red fluorescent protein rhoptry ROP1-mCherry near the apical end. …”
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“…The surfactant phase included a mixture of polyoxyethylene sorbitan monooleate (PSM) and various cosurfactants (ethanol, 2-(2-ethoxyethoxy) ethanol, or 2-propanol). …”
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“…The EMT inhibitory effect from metformin used in the treatment of type 2 diabetic patients has been studied in large cohorts of patients with different cancer types; however, the mechanism of protection from metformin to colorectal cancer spread is still unknown, especially in the context of non-diabetes. Sortilin is a poor prognostic marker in CRC that may be related to signaling pathways that metformin could downregulate. …”
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“…(V.) pseudobiserra sp. nov.,  T. (V.) survilai sp. nov., and T. (V.) taiwanica sp. nov. Three species, T. biaciculifera Alexander, 1937, T. niitakensis Alexander, 1938, and T. pseudobiaciculifera Men, Xue and Wang, 2016, listed previously as members of the subgenus T. …”
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“…The Vps10p-domain (Vps10p-D) receptor family consists of Sortilin, SorLA, SorCS1, SorCS2, and SorCS3. They mediate internalization and intracellular sorting of specific cargo in various cell types, but underlying molecular determinants are incompletely understood. …”
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“…A traditional emulsion containing sorbitan monooleate as the surfactant was used as a research benchmark to compare against the novel emulsion’s stability and performance in minerals recovery. …”
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“…We hypothesized that bispecific antibody–drug conjugate (bsADC) targeting HER2 and Sortilin-1 (SORT1) would overcome this limitation. …”
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