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Mostrando 61 - 80 Resultados de 720 Para Buscar 'Sorvilán~', tiempo de consulta: 4.15s Limitar resultados
  1. 61
    “…Furthermore, Presenilin1 interacted with Sortilin at the transmembrane domain and repressed Sortilin expression by cleaving it in glioblastoma cells. …”
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    Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage
  2. 62
    “…Sortilin is a glycoprotein mainly known for its role as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. …”
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    Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress
  3. 63
    “…BACKGROUND: Sortilin has an important role in various malignances and can be used as a promising target to eradicate cancer cells. …”
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    Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells
  4. 64
    “…In this study, we mapped the binding site between progranulin and sortilin. Progranulin binds to the beta-propeller region of sortilin through its C-terminal tail. …”
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    C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking
  5. 65
    “…Alzheimer’s disease (AD) is a neurodegenerative disorder represented by the accumulation of intracellular tau protein and extracellular deposits of amyloid-β (Aβ) in the brain. The gene sortilin 1 (SORT1) has previously been associated with cardiovascular disease in gene association studies. …”
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    A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer’s Disease
  6. 66
    “…Sortilin was first identified based on its activity as part of intracellular protein sorting machinery. …”
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    Development of a Cell-Based Assay to Assess Binding of the proNGF Prodomain to Sortilin
  7. 67
    “…The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. …”
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    Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin
  8. 68
    “…The trafficking protein, sortilin, regulates major glucose transporter 4 (Glut4) movement, thereby promoting glucose uptake in adipocytes. …”
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    Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes
  9. 69
    “…However, the role of hepatic sortilin remains controversial, as genetic deletion of sortilin in mice has resulted in variable and conflicting effects on apoB secretion. …”
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    Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions
  10. 70
    “…This study aims to characterize the effects of sortilin deletion on nerve regeneration following sciatic crush injury. …”
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    Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
  11. 71
    “…The present study looked for the effect of solid emulsifiers; namely, sorbitan monostearate (SP) and stearyl alcohol (SA), on the physicochemical parameters of oleogels. …”
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    Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels
  12. 72
    “…METHODS AND RESULTS: An aortic valve (AV) wire injury (AVWI) mouse model with sortilin deficiency was used to determine the effects of sortilin on AV stenosis, fibrosis, and calcification. …”
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    Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity
  13. 73
    por Corvalán, Luis, 1916-2010
    Publicado 1977
    Libro
    Algo de mi vida
  14. 74
    “…Thus, we demonstrate that GLP1 regulates alternative splicing of sortilin in human diabetic adipocytes.…”
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    Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes
  15. 75
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    Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction
  16. 76
    “…To assess the role of sortilin in the sorting and trafficking of sphingolipid activator proteins (SAPs) the function of sortilin was abolished by a dominant-negative mutant and by the use of RNAi. …”
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    Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference
  17. 77
    “…Sortilin is a multiligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrates. …”
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    Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes
  18. 78
    “…The molecular mechanisms of pH-mediated ligand release and sortilin recycling are unresolved. Here we present crystal structures that show the sortilin luminal segment (s-sortilin) undergoes a conformational change and dimerizes at low pH. …”
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    Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
  19. 79
    “…METHODS: We set out to explore if extracellular sortilin neuropathology exists in AD-related transgenic mice and nonhuman primates. …”
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    Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques
  20. 80
    “…The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice deleted from the gene encoding sortilin (Sort1(−/−)). …”
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    Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
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