A Single-Center, Open-Label, 3-Way Crossover Trial to Determine the Pharmacokinetic and Pharmacodynamic Interaction Between Nebivolol and Valsartan in Healthy Volunteers at Steady...

por Chen, Chun Lin, Desai-Krieger, Daksha, Ortiz, Stephan, Kerolous, Majid, Wright, Harold M., Ghahramani, Parviz
Publicado 2015

Bendamustine followed by ofatumumab and ibrutinib in chronic lymphocytic leukemia: primary endpoint analysis of a multicenter, open-label, phase II trial (CLL2-BIO)

por Cramer, Paula, von Tresckow, Julia, Robrecht, Sandra, Bahlo, Jasmin, Furstenau, Moritz, Langerbeins, Petra, Pflug, Natali, Al-Sawaf, Othman, Heinz, Werner J., Vehling-Kaiser, Ursula, Durig, Jan, Tausch, Eugen, Hensel, Manfred, Sasse, Stephanie, Fink, Anna-Maria, Fischer, Kirsten, Kreuzer, Karl-Anton, Bottcher, Sebastian, Ritgen, Matthias, Kneba, Michael, Wendtner, Clemens-Martin, Stilgenbauer, Stephan, Eichhorst, Barbara, Hallek, Michael
Publicado 2020

Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy

por Bierhoff, Marieke, Nelson, Kenrad E, Guo, Nan, Jia, Yuanxi, Angkurawaranon, Chaisiri, Jittamala, Podjanee, Carrara, Verena, Watthanaworawit, Wanitda, Ling, Clare, Tongprasert, Fuanglada, van Vugt, Michele, Rijken, Marcus, Nosten, Francois, McGready, Rose, Ehrhardt, Stephan, Thio, Chloe Lynne
Publicado 2020

Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falc...

por Wootton, Daniel G., Opara, Hyginus, Biagini, Giancarlo A., Kanjala, Maxwell K., Duparc, Stephan, Kirby, Paula L., Woessner, Mary, Neate, Colin, Nyirenda, Maggie, Blencowe, Hannah, Dube-Mbeye, Queen, Kanyok, Thomas, Ward, Stephen, Molyneux, Malcolm, Dunyo, Sam, Winstanley, Peter A.
Publicado 2008

Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial

por Bauer, Axel, Schreinlechner, Michael, Sappler, Nikolay, Dolejsi, Theresa, Tilg, Herbert, Aulinger, Benedikt A, Weiss, Günter, Bellmann-Weiler, Rosa, Adolf, Christian, Wolf, Dominik, Pirklbauer, Markus, Graziadei, Ivo, Gänzer, Hannes, von Bary, Christian, May, Andreas E, Wöll, Ewald, von Scheidt, Wolfgang, Rassaf, Tienush, Duerschmied, Daniel, Brenner, Christoph, Kääb, Stefan, Metzler, Bernhard, Joannidis, Michael, Kain, Hans-Ulrich, Kaiser, Norbert, Schwinger, Robert, Witzenbichler, Bernhard, Alber, Hannes, Straube, Florian, Hartmann, Niels, Achenbach, Stephan, von Bergwelt-Baildon, Michael, von Stülpnagel, Lukas, Schoenherr, Sebastian, Forer, Lukas, Embacher-Aichhorn, Sabine, Mansmann, Ulrich, Rizas, Konstantinos D, Massberg, Steffen
Publicado 2021

Volumetric Nanoscale Imaging: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit (Adv. Sci. 6/2018)

por Khimchenko, Anna, Bikis, Christos, Pacureanu, Alexandra, Hieber, Simone E., Thalmann, Peter, Deyhle, Hans, Schweighauser, Gabriel, Hench, Jürgen, Frank, Stephan, Müller‐Gerbl, Magdalena, Schulz, Georg, Cloetens, Peter, Müller, Bert
Publicado 2018

Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women...

por Kimani, Joshua, Phiri, Kamija, Kamiza, Steve, Duparc, Stephan, Ayoub, Ayman, Rojo, Ricardo, Robbins, Jeffery, Orrico, Russell, Vandenbroucke, Pol
Publicado 2016

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase...

por Phyo, Aung Pyae, Jittamala, Podjanee, Nosten, François H, Pukrittayakamee, Sasithon, Imwong, Mallika, White, Nicholas J, Duparc, Stephan, Macintyre, Fiona, Baker, Mark, Möhrle, Jörg J
Publicado 2016

Pyronaridine–artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

por Tona Lutete, Gaston, Mombo-Ngoma, Ghyslain, Assi, Serge-Brice, Bigoga, Jude D., Koukouikila-Koussounda, Felix, Ntamabyaliro, Nsengi Y., Ntoumi, Francine, Agnandji, Selidji T., Groger, Mirjam, Shin, Jangsik, Borghini-Fuhrer, Isabelle, Arbe-Barnes, Sarah, Allen, Stephen J., Kremsner, Peter G., Miller, Robert, Duparc, Stephan, Ramharter, Michael
Publicado 2021

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform...

por Butler, Christopher C, Yu, Ly-Mee, Dorward, Jienchi, Gbinigie, Oghenekome, Hayward, Gail, Saville, Benjamin R, Van Hecke, Oliver, Berry, Nicholas, Detry, Michelle A, Saunders, Christina, Fitzgerald, Mark, Harris, Victoria, Djukanovic, Ratko, Gadola, Stephan, Kirkpatrick, John, de Lusignan, Simon, Ogburn, Emma, Evans, Philip H, Thomas, Nicholas P B, Patel, Mahendra G, Hobbs, F D Richard
Publicado 2021

Efficacy and Safety of Switching to Dolutegravir With Boosted Darunavir in Virologically Suppressed Adults With HIV-1: A Randomized, Open-Label, Multicenter, Phase 3, Noninferiorit...

por Spinner, Christoph D, Kümmerle, Tim, Schneider, Jochen, Cordes, Christiane, Heiken, Hans, Stellbrink, Hans-Jürgen, Krznaric, Ivanka, Scholten, Stephan, Jensen, Björn, Wyen, Christoph, Viehweger, Marin, Lehmann, Clara, Sprinzl, Martin, Stoehr, Albrecht, Bickel, Markus, Jessen, Heiko, Obst, Wilfried, Spornraft-Ragaller, Petra, Khaykin, Pavel, Wolf, Eva, Boesecke, Christoph
Publicado 2020

Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients wit...

por Gansane, Adama, Lingani, Moussa, Yeka, Adoke, Nahum, Alain, Bouyou-Akotet, Marielle, Mombo-Ngoma, Ghyslain, Kaguthi, Grace, Barceló, Catalina, Laurijssens, Bart, Cantalloube, Cathy, Macintyre, Fiona, Djeriou, Elhadj, Jessel, Andreas, Bejuit, Raphaël, Demarest, Helen, Marrast, Anne Claire, Debe, Siaka, Tinto, Halidou, Kibuuka, Afizi, Nahum, Diolinda, Mawili-Mboumba, Denise Patricia, Zoleko-Manego, Rella, Mugenya, Irene, Olewe, Frederick, Duparc, Stephan, Ogutu, Bernhards
Publicado 2023

Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep

por Chantepie, Louise, Bodin, Loys, Sarry, Julien, Woloszyn, Florent, Plisson-Petit, Florence, Ruesche, Julien, Drouilhet, Laurence, Fabre, Stéphane
Publicado 2020

Early versus differed arterial catheterisation in critically ill patients with acute circulatory failure: a multicentre, open-label, pragmatic, randomised, non-inferiority controll...

por Muller, Grégoire, Kamel, Toufik, Contou, Damien, Ehrmann, Stephan, Martin, Maëlle, Quenot, Jean-Pierre, Lacherade, Jean-Claude, Boissier, Florence, Monnier, Alexandra, Vimeux, Sylvie, Brunet Houdard, Solène, Tavernier, Elsa, Boulain, Thierry
Publicado 2021

Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: A randomized, controlled, open-label, parallel group tria...

por Dhar, Raja, Kirkpatrick, John, Gilbert, Laura, Khanna, Arjun, Modi, Mahavir Madhavdas, Chawla, Rakesh K., Dalal, Sonia, Maturu, Venkata Nagarjuna, Stern, Marcel, Keppler, Oliver T., Djukanovic, Ratko, Gadola, Stephan D.
Publicado 2023

Lipid profile with eslicarbazepine acetate and carbamazepine monotherapy in adult patients with newly diagnosed focal seizures: post hoc analysis of a phase III trial and open-labe...

por Trinka, Eugen, Rocamora, Rodrigo, Chaves, João, Koepp, Mathias J., Rüegg, Stephan, Holtkamp, Martin, Moreira, Joana, Fonseca, Miguel M., Castilla-Fernández, Guillermo, Ikedo, Fábio
Publicado 2023

Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical...

por Chandiwana, Nomathemba, Kruger, Chelsea, Johnstone, Hilary, Chughlay, Mohamed Farouk, Ju, Chung, Kim, Byungsu, Dineka, Yengiwe, Arbe-Barnes, Sarah, Miller, Robert, Owen, Andrew, Hill, Andrew, Windgassen, Daniel, Abla, Nada, Marrast, Anne Claire, Duparc, Stephan, Francois Venter, Willem Daniel
Publicado 2022

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ((2)H) and indirect ((1)H) detection of deuterium labeled compounds at 7T and clinical 3T

por Niess, Fabian, Strasser, Bernhard, Hingerl, Lukas, Niess, Eva, Motyka, Stanislav, Hangel, Gilbert, Krššák, Martin, Gruber, Stephan, Spurny-Dworak, Benjamin, Trattnig, Siegfried, Scherer, Thomas, Lanzenberger, Rupert, Bogner, Wolfgang
Publicado 2023

Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 t...

por Folegatti, Pedro M, Bittaye, Mustapha, Flaxman, Amy, Lopez, Fernando Ramos, Bellamy, Duncan, Kupke, Alexandra, Mair, Catherine, Makinson, Rebecca, Sheridan, Jonathan, Rohde, Cornelius, Halwe, Sandro, Jeong, Yuji, Park, Young-Shin, Kim, Jae-Ouk, Song, Manki, Boyd, Amy, Tran, Nguyen, Silman, Daniel, Poulton, Ian, Datoo, Mehreen, Marshall, Julia, Themistocleous, Yrene, Lawrie, Alison, Roberts, Rachel, Berrie, Eleanor, Becker, Stephan, Lambe, Teresa, Hill, Adrian, Ewer, Katie, Gilbert, Sarah
Publicado 2020

Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial

por Francois, Bruno, Lambden, Simon, Gibot, Sebastien, Derive, Marc, Olivier, Aurelie, Cuvier, Valerie, Witte, Stephan, Grouin, Jean-Marie, Garaud, Jean Jacques, Salcedo-Magguilli, Margarita, Levy, Mitchell, Laterre, Pierre-François
Publicado 2021